Synthetic Peptides as cGMP-Independent Activators of cGMP-Dependent Protein Kinase Iα

PKG is a multifaceted signaling molecule and potential pharmaceutical target due to its role in smooth muscle function. A helix identified in the structure of the regulatory domain of PKG Iα suggests a novel architecture of the holoenzyme. In this study, a set of synthetic peptides (S-tides), derive...

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Veröffentlicht in:	Chemistry & biology 2015-12, Vol.22 (12), p.1653-1661
Hauptverfasser:	Moon, Thomas M., Tykocki, Nathan R., Sheehe, Jessica L., Osborne, Brent W., Tegge, Werner, Brayden, Joseph E., Dostmann, Wolfgang R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Circular Dichroism Cyclic GMP Cyclic GMP-Dependent Protein Kinase Type I - isolation & purification Cyclic GMP-Dependent Protein Kinase Type I - metabolism Drug Design Enzyme Activation - drug effects Enzyme Activators - chemical synthesis Enzyme Activators - pharmacology Microscopy, Confocal Muscle, Smooth, Vascular - drug effects Peptide Library Peptides - chemical synthesis Peptides - pharmacology Protein Isoforms - isolation & purification Rats
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