Unveiling the crucial intermediates in androgen production

Ablation of androgen production through surgery is one strategy against prostate cancer, with the current focus placed on pharmaceutical intervention to restrict androgen synthesis selectively, an endeavor that could benefit from the enhanced understanding of enzymatic mechanisms that derives from c...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-12, Vol.112 (52), p.15856-15861
Hauptverfasser:	Mak, Piotr J., Gregory, Michael C., Denisov, Ilia G., Sligar, Stephen G., Kincaid, James R.
Format:	Artikel
Sprache:	eng
Schlagworte:	17-alpha-Hydroxypregnenolone - chemistry 17-alpha-Hydroxypregnenolone - metabolism Androgens Androgens - chemistry Androgens - metabolism Biocatalysis Biological Sciences Biosynthetic Pathways Carbon Chemical bonds Chemical reactions Dehydroepiandrosterone - chemistry Dehydroepiandrosterone - metabolism Humans Hydrogen Bonding Hydroxylation Models, Chemical Models, Molecular Molecular Structure Physical Sciences Pregnenolone - chemistry Pregnenolone - metabolism Prostate cancer Protein Conformation Spectrophotometry - methods Steroid 17-alpha-Hydroxylase - chemistry Steroid 17-alpha-Hydroxylase - genetics Steroid 17-alpha-Hydroxylase - metabolism Substrate Specificity Temperature
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