Free 25(OH)D and Calcium Absorption, PTH, and Markers of Bone Turnover
Context: It has been proposed that serum free 25-hydroxyvitamin D [25(OH)D] may better reflect vitamin D action than total 25(OH)D. An ELISA for serum free 25(OH)D has recently become available, permitting direct assay. Objective: To determine whether serum free 25(OH)D provides additional informati...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2015-11, Vol.100 (11), p.4140-4145 |
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| creator | Aloia, John Dhaliwal, Ruban Mikhail, Mageda Shieh, Albert Stolberg, Alexandra Ragolia, Louis Fazzari, Melissa Abrams, Steven A |
| description | Context:
It has been proposed that serum free 25-hydroxyvitamin D [25(OH)D] may better reflect vitamin D action than total 25(OH)D. An ELISA for serum free 25(OH)D has recently become available, permitting direct assay.
Objective:
To determine whether serum free 25(OH)D provides additional information in relation to calcium absorption and other biomarkers of vitamin D action compared to total serum 25(OH)D.
Setting:
Ambulatory research setting in a teaching hospital.
Outcome:
Serum free 25(OH)D measured in a previously performed study of varied doses of vitamin D3 (placebo and 800, 2000, and 4000 IU) on calcium absorption, PTH, procollagen type 1 N-terminal propeptide, and C-terminal telopeptides of type I collagen. Free 25(OH)D was measured by ELISA. Calcium absorption was measured at baseline and at 10 weeks using stable dual calcium isotopes.
Results:
Seventy-one subjects completed this randomized, placebo-controlled trial. Baseline group mean free and total 25(OH)D varied from 4.7 ± 1.8 to 5.4 ± 1.5 pg/mL, and from 23.7 ± 5.9 to 25.9 ± 6.1 ng/mL, respectively. Participants assigned to the 4000-IU dose arm achieved free 25(OH)D levels of 10.4 pg/mL and total 25(OH)D levels of 40.4 ng/mL. Total and free 25(OH)D were highly correlated at baseline and after increasing vitamin D dosing (r = 0.80 and 0.85, respectively). Free 25(OH)D closely reflected changes in total 25(OH)D. PTH was similarly correlated at baseline and follow-up with total and free 25(OH)D. Serum C-terminal telopeptides of type I collagen had a moderate positive correlation with total and free 25(OH)D at follow-up. The serum 1,25-dihydroxyvitamin D change increased significantly with the change in 25(OH)D but not with the change in free 25(OH)D.
Conclusion:
There was no advantage from measuring free over total 25(OH)D in assessing the response of calcium absorption, PTH, and markers of bone turnover to vitamin D. Free 25(OH)D responded to increasing doses of vitamin D in a similar fashion to total 25(OH)D. |
| doi_str_mv | 10.1210/jc.2015-2548 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4702446</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1731783954</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4730-b78d08a3a387df74f7b37876de7ed0ce571940433c8b58f60232a155fcceaa4e3</originalsourceid><addsrcrecordid>eNptkM9r2zAUx8XYWNNut52Hjy3EnX5aymXQpktT6MgOKfQmZPm5cepIqWS39L-f3GSlgwqEEO_zvu_xQegbwaeEEvxjbU8pJiKngqsPaEQmXOSSTORHNMKYknwi6e0BOoxxjTHhXLDP6IAWjFCh8AjNZgEgo-J4MT-5yIyrsqlpbdNvsrMy-rDtGu_G2Z_lfPxS_G3CPYSY-To79w6yZR-cf4TwBX2qTRvh6_49QjezX8vpPL9eXF5Nz65zyyXDeSlVhZVhhilZ1ZLXsmRSyaICCRW2INLiHHPGrCqFqgtMGTVEiNpaMIYDO0I_d7nbvtxAZcF1wbR6G5qNCc_am0b_X3HNSt_5R80lppwXKeB4HxD8Qw-x05smWmhb48D3URPJiFRsInhCxzvUBh9jgPp1DMF6UK_XVg_q9aA-4d_frvYK_3OdAL4DnnzbJYn3bf8EQa_AtN1K43R4IVU-JBKSfnm6dGhjuzZwlbehcbANEKNe--Q-uX5_m7-wzZ3A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1731783954</pqid></control><display><type>article</type><title>Free 25(OH)D and Calcium Absorption, PTH, and Markers of Bone Turnover</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><source>Journals@Ovid Complete</source><creator>Aloia, John ; Dhaliwal, Ruban ; Mikhail, Mageda ; Shieh, Albert ; Stolberg, Alexandra ; Ragolia, Louis ; Fazzari, Melissa ; Abrams, Steven A</creator><creatorcontrib>Aloia, John ; Dhaliwal, Ruban ; Mikhail, Mageda ; Shieh, Albert ; Stolberg, Alexandra ; Ragolia, Louis ; Fazzari, Melissa ; Abrams, Steven A</creatorcontrib><description>Context:
It has been proposed that serum free 25-hydroxyvitamin D [25(OH)D] may better reflect vitamin D action than total 25(OH)D. An ELISA for serum free 25(OH)D has recently become available, permitting direct assay.
Objective:
To determine whether serum free 25(OH)D provides additional information in relation to calcium absorption and other biomarkers of vitamin D action compared to total serum 25(OH)D.
Setting:
Ambulatory research setting in a teaching hospital.
Outcome:
Serum free 25(OH)D measured in a previously performed study of varied doses of vitamin D3 (placebo and 800, 2000, and 4000 IU) on calcium absorption, PTH, procollagen type 1 N-terminal propeptide, and C-terminal telopeptides of type I collagen. Free 25(OH)D was measured by ELISA. Calcium absorption was measured at baseline and at 10 weeks using stable dual calcium isotopes.
Results:
Seventy-one subjects completed this randomized, placebo-controlled trial. Baseline group mean free and total 25(OH)D varied from 4.7 ± 1.8 to 5.4 ± 1.5 pg/mL, and from 23.7 ± 5.9 to 25.9 ± 6.1 ng/mL, respectively. Participants assigned to the 4000-IU dose arm achieved free 25(OH)D levels of 10.4 pg/mL and total 25(OH)D levels of 40.4 ng/mL. Total and free 25(OH)D were highly correlated at baseline and after increasing vitamin D dosing (r = 0.80 and 0.85, respectively). Free 25(OH)D closely reflected changes in total 25(OH)D. PTH was similarly correlated at baseline and follow-up with total and free 25(OH)D. Serum C-terminal telopeptides of type I collagen had a moderate positive correlation with total and free 25(OH)D at follow-up. The serum 1,25-dihydroxyvitamin D change increased significantly with the change in 25(OH)D but not with the change in free 25(OH)D.
Conclusion:
There was no advantage from measuring free over total 25(OH)D in assessing the response of calcium absorption, PTH, and markers of bone turnover to vitamin D. Free 25(OH)D responded to increasing doses of vitamin D in a similar fashion to total 25(OH)D.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2015-2548</identifier><identifier>PMID: 26312580</identifier><language>eng</language><publisher>United States: Endocrine Society</publisher><subject>Adult ; Aged ; Biomarkers ; Bone and Bones - metabolism ; Bone Remodeling ; Calcium - metabolism ; Collagen Type I - blood ; Dose-Response Relationship, Drug ; Female ; Humans ; Hydroxycholecalciferols - blood ; Hydroxycholecalciferols - metabolism ; Hydroxycholecalciferols - pharmacology ; Male ; Middle Aged ; Original ; Parathyroid Hormone - metabolism ; Vitamins - blood ; Vitamins - pharmacology ; Young Adult</subject><ispartof>The journal of clinical endocrinology and metabolism, 2015-11, Vol.100 (11), p.4140-4145</ispartof><rights>Copyright © 2015 by the Endocrine Society</rights><rights>Copyright © 2015 by The Endocrine Society</rights><rights>Copyright © 2015 by the Endocrine Society 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4730-b78d08a3a387df74f7b37876de7ed0ce571940433c8b58f60232a155fcceaa4e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26312580$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aloia, John</creatorcontrib><creatorcontrib>Dhaliwal, Ruban</creatorcontrib><creatorcontrib>Mikhail, Mageda</creatorcontrib><creatorcontrib>Shieh, Albert</creatorcontrib><creatorcontrib>Stolberg, Alexandra</creatorcontrib><creatorcontrib>Ragolia, Louis</creatorcontrib><creatorcontrib>Fazzari, Melissa</creatorcontrib><creatorcontrib>Abrams, Steven A</creatorcontrib><title>Free 25(OH)D and Calcium Absorption, PTH, and Markers of Bone Turnover</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Context:
It has been proposed that serum free 25-hydroxyvitamin D [25(OH)D] may better reflect vitamin D action than total 25(OH)D. An ELISA for serum free 25(OH)D has recently become available, permitting direct assay.
Objective:
To determine whether serum free 25(OH)D provides additional information in relation to calcium absorption and other biomarkers of vitamin D action compared to total serum 25(OH)D.
Setting:
Ambulatory research setting in a teaching hospital.
Outcome:
Serum free 25(OH)D measured in a previously performed study of varied doses of vitamin D3 (placebo and 800, 2000, and 4000 IU) on calcium absorption, PTH, procollagen type 1 N-terminal propeptide, and C-terminal telopeptides of type I collagen. Free 25(OH)D was measured by ELISA. Calcium absorption was measured at baseline and at 10 weeks using stable dual calcium isotopes.
Results:
Seventy-one subjects completed this randomized, placebo-controlled trial. Baseline group mean free and total 25(OH)D varied from 4.7 ± 1.8 to 5.4 ± 1.5 pg/mL, and from 23.7 ± 5.9 to 25.9 ± 6.1 ng/mL, respectively. Participants assigned to the 4000-IU dose arm achieved free 25(OH)D levels of 10.4 pg/mL and total 25(OH)D levels of 40.4 ng/mL. Total and free 25(OH)D were highly correlated at baseline and after increasing vitamin D dosing (r = 0.80 and 0.85, respectively). Free 25(OH)D closely reflected changes in total 25(OH)D. PTH was similarly correlated at baseline and follow-up with total and free 25(OH)D. Serum C-terminal telopeptides of type I collagen had a moderate positive correlation with total and free 25(OH)D at follow-up. The serum 1,25-dihydroxyvitamin D change increased significantly with the change in 25(OH)D but not with the change in free 25(OH)D.
Conclusion:
There was no advantage from measuring free over total 25(OH)D in assessing the response of calcium absorption, PTH, and markers of bone turnover to vitamin D. Free 25(OH)D responded to increasing doses of vitamin D in a similar fashion to total 25(OH)D.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers</subject><subject>Bone and Bones - metabolism</subject><subject>Bone Remodeling</subject><subject>Calcium - metabolism</subject><subject>Collagen Type I - blood</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Humans</subject><subject>Hydroxycholecalciferols - blood</subject><subject>Hydroxycholecalciferols - metabolism</subject><subject>Hydroxycholecalciferols - pharmacology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Parathyroid Hormone - metabolism</subject><subject>Vitamins - blood</subject><subject>Vitamins - pharmacology</subject><subject>Young Adult</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM9r2zAUx8XYWNNut52Hjy3EnX5aymXQpktT6MgOKfQmZPm5cepIqWS39L-f3GSlgwqEEO_zvu_xQegbwaeEEvxjbU8pJiKngqsPaEQmXOSSTORHNMKYknwi6e0BOoxxjTHhXLDP6IAWjFCh8AjNZgEgo-J4MT-5yIyrsqlpbdNvsrMy-rDtGu_G2Z_lfPxS_G3CPYSY-To79w6yZR-cf4TwBX2qTRvh6_49QjezX8vpPL9eXF5Nz65zyyXDeSlVhZVhhilZ1ZLXsmRSyaICCRW2INLiHHPGrCqFqgtMGTVEiNpaMIYDO0I_d7nbvtxAZcF1wbR6G5qNCc_am0b_X3HNSt_5R80lppwXKeB4HxD8Qw-x05smWmhb48D3URPJiFRsInhCxzvUBh9jgPp1DMF6UK_XVg_q9aA-4d_frvYK_3OdAL4DnnzbJYn3bf8EQa_AtN1K43R4IVU-JBKSfnm6dGhjuzZwlbehcbANEKNe--Q-uX5_m7-wzZ3A</recordid><startdate>201511</startdate><enddate>201511</enddate><creator>Aloia, John</creator><creator>Dhaliwal, Ruban</creator><creator>Mikhail, Mageda</creator><creator>Shieh, Albert</creator><creator>Stolberg, Alexandra</creator><creator>Ragolia, Louis</creator><creator>Fazzari, Melissa</creator><creator>Abrams, Steven A</creator><general>Endocrine Society</general><general>Copyright by The Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201511</creationdate><title>Free 25(OH)D and Calcium Absorption, PTH, and Markers of Bone Turnover</title><author>Aloia, John ; Dhaliwal, Ruban ; Mikhail, Mageda ; Shieh, Albert ; Stolberg, Alexandra ; Ragolia, Louis ; Fazzari, Melissa ; Abrams, Steven A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4730-b78d08a3a387df74f7b37876de7ed0ce571940433c8b58f60232a155fcceaa4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers</topic><topic>Bone and Bones - metabolism</topic><topic>Bone Remodeling</topic><topic>Calcium - metabolism</topic><topic>Collagen Type I - blood</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Humans</topic><topic>Hydroxycholecalciferols - blood</topic><topic>Hydroxycholecalciferols - metabolism</topic><topic>Hydroxycholecalciferols - pharmacology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Parathyroid Hormone - metabolism</topic><topic>Vitamins - blood</topic><topic>Vitamins - pharmacology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aloia, John</creatorcontrib><creatorcontrib>Dhaliwal, Ruban</creatorcontrib><creatorcontrib>Mikhail, Mageda</creatorcontrib><creatorcontrib>Shieh, Albert</creatorcontrib><creatorcontrib>Stolberg, Alexandra</creatorcontrib><creatorcontrib>Ragolia, Louis</creatorcontrib><creatorcontrib>Fazzari, Melissa</creatorcontrib><creatorcontrib>Abrams, Steven A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aloia, John</au><au>Dhaliwal, Ruban</au><au>Mikhail, Mageda</au><au>Shieh, Albert</au><au>Stolberg, Alexandra</au><au>Ragolia, Louis</au><au>Fazzari, Melissa</au><au>Abrams, Steven A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Free 25(OH)D and Calcium Absorption, PTH, and Markers of Bone Turnover</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2015-11</date><risdate>2015</risdate><volume>100</volume><issue>11</issue><spage>4140</spage><epage>4145</epage><pages>4140-4145</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>Context:
It has been proposed that serum free 25-hydroxyvitamin D [25(OH)D] may better reflect vitamin D action than total 25(OH)D. An ELISA for serum free 25(OH)D has recently become available, permitting direct assay.
Objective:
To determine whether serum free 25(OH)D provides additional information in relation to calcium absorption and other biomarkers of vitamin D action compared to total serum 25(OH)D.
Setting:
Ambulatory research setting in a teaching hospital.
Outcome:
Serum free 25(OH)D measured in a previously performed study of varied doses of vitamin D3 (placebo and 800, 2000, and 4000 IU) on calcium absorption, PTH, procollagen type 1 N-terminal propeptide, and C-terminal telopeptides of type I collagen. Free 25(OH)D was measured by ELISA. Calcium absorption was measured at baseline and at 10 weeks using stable dual calcium isotopes.
Results:
Seventy-one subjects completed this randomized, placebo-controlled trial. Baseline group mean free and total 25(OH)D varied from 4.7 ± 1.8 to 5.4 ± 1.5 pg/mL, and from 23.7 ± 5.9 to 25.9 ± 6.1 ng/mL, respectively. Participants assigned to the 4000-IU dose arm achieved free 25(OH)D levels of 10.4 pg/mL and total 25(OH)D levels of 40.4 ng/mL. Total and free 25(OH)D were highly correlated at baseline and after increasing vitamin D dosing (r = 0.80 and 0.85, respectively). Free 25(OH)D closely reflected changes in total 25(OH)D. PTH was similarly correlated at baseline and follow-up with total and free 25(OH)D. Serum C-terminal telopeptides of type I collagen had a moderate positive correlation with total and free 25(OH)D at follow-up. The serum 1,25-dihydroxyvitamin D change increased significantly with the change in 25(OH)D but not with the change in free 25(OH)D.
Conclusion:
There was no advantage from measuring free over total 25(OH)D in assessing the response of calcium absorption, PTH, and markers of bone turnover to vitamin D. Free 25(OH)D responded to increasing doses of vitamin D in a similar fashion to total 25(OH)D.</abstract><cop>United States</cop><pub>Endocrine Society</pub><pmid>26312580</pmid><doi>10.1210/jc.2015-2548</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The journal of clinical endocrinology and metabolism, 2015-11, Vol.100 (11), p.4140-4145 |
| issn | 0021-972X 1945-7197 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Adult Aged Biomarkers Bone and Bones - metabolism Bone Remodeling Calcium - metabolism Collagen Type I - blood Dose-Response Relationship, Drug Female Humans Hydroxycholecalciferols - blood Hydroxycholecalciferols - metabolism Hydroxycholecalciferols - pharmacology Male Middle Aged Original Parathyroid Hormone - metabolism Vitamins - blood Vitamins - pharmacology Young Adult |
| title | Free 25(OH)D and Calcium Absorption, PTH, and Markers of Bone Turnover |
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