A multi-factorial analysis of response to warfarin in a UK prospective cohort

Warfarin is the most widely used oral anticoagulant worldwide, but it has a narrow therapeutic index which necessitates constant monitoring of anticoagulation response. Previous genome-wide studies have focused on identifying factors explaining variance in stable dose, but have not explored the init...

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Veröffentlicht in:	Genome medicine 2016-01, Vol.8 (1), p.2, Article 2
Hauptverfasser:	Bourgeois, Stephane, Jorgensen, Andrea, Zhang, Eunice J, Hanson, Anita, Gillman, Matthew S, Bumpstead, Suzannah, Toh, Cheng Hock, Williamson, Paula, Daly, Ann K, Kamali, Farhad, Deloukas, Panos, Pirmohamed, Munir
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Anticoagulants - administration & dosage Cytochrome P-450 Cytochrome P-450 CYP2C9 - genetics Cytochrome P-450 Enzyme System - genetics Cytochrome P450 Family 4 Dose-Response Relationship, Drug Female Follow-Up Studies Genetic polymorphisms Genomics Genotype Health aspects Humans International Normalized Ratio Male Middle Aged Polymorphism, Single Nucleotide Prospective Studies Risk Factors Smoking United Kingdom Vitamin K Epoxide Reductases - genetics Warfarin Warfarin - administration & dosage Young Adult
Online-Zugang:	Volltext
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