Next-Generation Bacillus anthracis Live Attenuated Spore Vaccine Based on the htrA- (High Temperature Requirement A) Sterne Strain

Anthrax is a lethal disease caused by the gram-positive spore-producing bacterium Bacillus anthracis . Live attenuated vaccines, such as the nonencapsulated Sterne strain, do not meet the safety standards mandated for human use in the Western world and are approved for veterinary purposes only. Here...

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Veröffentlicht in:	Scientific reports 2016-01, Vol.6 (1), p.18908-18908, Article 18908
Hauptverfasser:	Chitlaru, Theodor, Israeli, Ma’ayan, Bar-Haim, Erez, Elia, Uri, Rotem, Shahar, Ehrlich, Sharon, Cohen, Ofer, Shafferman, Avigdor
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/255/1318 631/326/421 Animal models Animals Anthrax Anthrax - immunology Anthrax - microbiology Anthrax - mortality Anthrax - prevention & control Anthrax Vaccines Antigens, Bacterial - biosynthesis Bacillus anthracis - genetics Bacillus anthracis - immunology Bacillus anthracis - metabolism Bacteremia Bacterial Proteins - genetics Bacterial Proteins - immunology Bacterial Toxins - biosynthesis Disease Models, Animal Gene Order Genetic Loci Guinea Pigs High temperature HtrA gene Humanities and Social Sciences Humans Immune response Immunization Mice multidisciplinary Phenotype Pre-eclampsia Rabbits Respiration Science Sequence Deletion Serine Endopeptidases - genetics Serine Endopeptidases - immunology Spores Spores, Bacterial Swine Temperature effects Temperature requirements Toxins Vaccines Vaccines, Attenuated Virulence Virulence - genetics Virulence Factors - genetics
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