Increased Sensitivity to Cocaine Self-Administration in HIV-1 Transgenic Rats is Associated with Changes in Striatal Dopamine Transporter Binding

Cocaine abuse in HIV patients accelerates the progression and severity of neuropathology, motor impairment and cognitive dysfunction compared to non-drug using HIV patients. Cocaine and HIV interact with the dopamine transporter (DAT); however, the effect of their interaction on DAT binding remains...

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Veröffentlicht in:	Journal of neuroimmune pharmacology 2015-09, Vol.10 (3), p.493-505
Hauptverfasser:	McIntosh, Scot, Sexton, Tammy, Pattison, Lindsey P., Childers, Steven R., Hemby, Scott E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - drug effects Binding sites Biomedical and Life Sciences Biomedicine Cell Biology Cocaine Cocaine - administration & dosage Cocaine - analogs & derivatives Cocaine - pharmacology Disease Models, Animal Dopamine Dopamine Plasma Membrane Transport Proteins - drug effects Dopamine Plasma Membrane Transport Proteins - metabolism Dopamine Uptake Inhibitors - administration & dosage Dopamine Uptake Inhibitors - pharmacology Dose-Response Relationship, Drug Heroin - administration & dosage Heroin - pharmacology HIV Infections - metabolism Human immunodeficiency virus Human immunodeficiency virus 1 Immunology Male Narcotics - administration & dosage Narcotics - pharmacology Neostriatum - drug effects Neostriatum - metabolism Neurosciences Original Article Pharmacology/Toxicology Protein Binding - drug effects Rats Rats, Inbred F344 Rats, Transgenic Rodents Self Administration Virology
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