Serum Antioxidants Are Associated with Serum Reproductive Hormones and Ovulation among Healthy Women
Evidence is growing that the equilibrium between reactive oxygen species and antioxidants plays a vital role in women's reproductive health. The objective of this study was to evaluate variations in serum antioxidant concentrations across the menstrual cycle and associations between antioxidant...
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| Veröffentlicht in: | The Journal of nutrition 2016-01, Vol.146 (1), p.98-106 |
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| creator | Mumford, Sunni L Browne, Richard W Schliep, Karen C Schmelzer, Jonathan Plowden, Torie C Michels, Kara A Sjaarda, Lindsey A Zarek, Shvetha M Perkins, Neil J Messer, Lynne C Radin, Rose G Wactawski-Wende, Jean Schisterman, Enrique F |
| description | Evidence is growing that the equilibrium between reactive oxygen species and antioxidants plays a vital role in women's reproductive health.
The objective of this study was to evaluate variations in serum antioxidant concentrations across the menstrual cycle and associations between antioxidants and reproductive hormones and anovulation among healthy women.
The BioCycle Study, a prospective cohort, followed 259 women aged 18-44 y for up to 2 menstrual cycles. Serum fat-soluble vitamin and micronutrient (α-tocopherol, γ-tocopherol, retinol, lutein, lycopene, and β-carotene), ascorbic acid, and reproductive hormone concentrations were measured 5-8 times/cycle. We used weighted linear mixed models to assess associations between antioxidants and hormone concentrations, after adjustment for age, race, body mass index, parity, sleep, pain medication use, total energy intake, concurrent hormones, serum cholesterol, F2-isoprostanes, and other antioxidants. Generalized linear models were used to identify associations with anovulation.
Serum antioxidant concentrations varied across the menstrual cycle. Retinol and α-tocopherol were associated with higher estradiol [RR: 1.00 pg/mL (95% CI: 0.67, 1.34 pg/mL); RR: 0.02 pg/mL (95% CI: 0.003, 0.03 pg/mL), respectively] and testosterone [RR: 0.61 ng/dL (95% CI: 0.44, 0.78 ng/dL); RR: 0.01 ng/dL (95% CI: 0.001, 0.01 ng/dL), respectively]. Ascorbic acid was associated with higher progesterone (RR: 0.15 ng/mL; 95% CI: 0.05, 0.25 ng/mL) and with lower follicle-stimulating hormone (RR: -0.06 mIU/mL; 95% CI: -0.09, -0.03 mIU/mL). The ratio of α- to γ-tocopherol was associated with an increased risk of anovulation (RR: 1.03; 95% CI: 1.01, 1.06).
These findings shed new light on the intricate associations between serum antioxidants and endogenous hormones in healthy premenopausal women and support the hypothesis that concentrations of serum vitamins affect steroidogenesis even after adjustment for oxidative stress. |
| doi_str_mv | 10.3945/jn.115.217620 |
| format | Article |
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The objective of this study was to evaluate variations in serum antioxidant concentrations across the menstrual cycle and associations between antioxidants and reproductive hormones and anovulation among healthy women.
The BioCycle Study, a prospective cohort, followed 259 women aged 18-44 y for up to 2 menstrual cycles. Serum fat-soluble vitamin and micronutrient (α-tocopherol, γ-tocopherol, retinol, lutein, lycopene, and β-carotene), ascorbic acid, and reproductive hormone concentrations were measured 5-8 times/cycle. We used weighted linear mixed models to assess associations between antioxidants and hormone concentrations, after adjustment for age, race, body mass index, parity, sleep, pain medication use, total energy intake, concurrent hormones, serum cholesterol, F2-isoprostanes, and other antioxidants. Generalized linear models were used to identify associations with anovulation.
Serum antioxidant concentrations varied across the menstrual cycle. Retinol and α-tocopherol were associated with higher estradiol [RR: 1.00 pg/mL (95% CI: 0.67, 1.34 pg/mL); RR: 0.02 pg/mL (95% CI: 0.003, 0.03 pg/mL), respectively] and testosterone [RR: 0.61 ng/dL (95% CI: 0.44, 0.78 ng/dL); RR: 0.01 ng/dL (95% CI: 0.001, 0.01 ng/dL), respectively]. Ascorbic acid was associated with higher progesterone (RR: 0.15 ng/mL; 95% CI: 0.05, 0.25 ng/mL) and with lower follicle-stimulating hormone (RR: -0.06 mIU/mL; 95% CI: -0.09, -0.03 mIU/mL). The ratio of α- to γ-tocopherol was associated with an increased risk of anovulation (RR: 1.03; 95% CI: 1.01, 1.06).
These findings shed new light on the intricate associations between serum antioxidants and endogenous hormones in healthy premenopausal women and support the hypothesis that concentrations of serum vitamins affect steroidogenesis even after adjustment for oxidative stress.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.3945/jn.115.217620</identifier><identifier>PMID: 26581679</identifier><language>eng</language><publisher>United States: American Society for Nutrition</publisher><subject>Adolescent ; Adult ; alpha-Tocopherol - blood ; Anovulation - blood ; Antioxidants - administration & dosage ; Ascorbic Acid - blood ; beta Carotene - blood ; Carotenoids - blood ; Energy Intake ; F2-Isoprostanes - blood ; Female ; Follicle Stimulating Hormone - blood ; gamma-Tocopherol - blood ; Humans ; Linear Models ; Lutein - blood ; Lycopene ; Menstrual Cycle - blood ; Menstrual Cycle - drug effects ; Nutritional Epidemiology ; Ovulation - drug effects ; Ovulation - metabolism ; Premenopause - blood ; Progesterone - blood ; Prospective Studies ; Surveys and Questionnaires ; Testosterone - blood ; Vitamin A - blood ; Young Adult</subject><ispartof>The Journal of nutrition, 2016-01, Vol.146 (1), p.98-106</ispartof><rights>2016 American Society for Nutrition.</rights><rights>2016 American Society for Nutrition 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-4974d1ab84e640831a99e42b319f1e7c5d9a2a0db45d1b6fdd9ae440b59f43e33</citedby><cites>FETCH-LOGICAL-c387t-4974d1ab84e640831a99e42b319f1e7c5d9a2a0db45d1b6fdd9ae440b59f43e33</cites><orcidid>0000-0003-0539-8110 ; 0000-0003-0133-3176 ; 0000-0003-3757-641X ; 0000-0003-2178-6623 ; 0000-0002-7332-6170 ; 0000-0003-2431-2079 ; 0000-0003-1771-3157</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26581679$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mumford, Sunni L</creatorcontrib><creatorcontrib>Browne, Richard W</creatorcontrib><creatorcontrib>Schliep, Karen C</creatorcontrib><creatorcontrib>Schmelzer, Jonathan</creatorcontrib><creatorcontrib>Plowden, Torie C</creatorcontrib><creatorcontrib>Michels, Kara A</creatorcontrib><creatorcontrib>Sjaarda, Lindsey A</creatorcontrib><creatorcontrib>Zarek, Shvetha M</creatorcontrib><creatorcontrib>Perkins, Neil J</creatorcontrib><creatorcontrib>Messer, Lynne C</creatorcontrib><creatorcontrib>Radin, Rose G</creatorcontrib><creatorcontrib>Wactawski-Wende, Jean</creatorcontrib><creatorcontrib>Schisterman, Enrique F</creatorcontrib><title>Serum Antioxidants Are Associated with Serum Reproductive Hormones and Ovulation among Healthy Women</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Evidence is growing that the equilibrium between reactive oxygen species and antioxidants plays a vital role in women's reproductive health.
The objective of this study was to evaluate variations in serum antioxidant concentrations across the menstrual cycle and associations between antioxidants and reproductive hormones and anovulation among healthy women.
The BioCycle Study, a prospective cohort, followed 259 women aged 18-44 y for up to 2 menstrual cycles. Serum fat-soluble vitamin and micronutrient (α-tocopherol, γ-tocopherol, retinol, lutein, lycopene, and β-carotene), ascorbic acid, and reproductive hormone concentrations were measured 5-8 times/cycle. We used weighted linear mixed models to assess associations between antioxidants and hormone concentrations, after adjustment for age, race, body mass index, parity, sleep, pain medication use, total energy intake, concurrent hormones, serum cholesterol, F2-isoprostanes, and other antioxidants. Generalized linear models were used to identify associations with anovulation.
Serum antioxidant concentrations varied across the menstrual cycle. Retinol and α-tocopherol were associated with higher estradiol [RR: 1.00 pg/mL (95% CI: 0.67, 1.34 pg/mL); RR: 0.02 pg/mL (95% CI: 0.003, 0.03 pg/mL), respectively] and testosterone [RR: 0.61 ng/dL (95% CI: 0.44, 0.78 ng/dL); RR: 0.01 ng/dL (95% CI: 0.001, 0.01 ng/dL), respectively]. Ascorbic acid was associated with higher progesterone (RR: 0.15 ng/mL; 95% CI: 0.05, 0.25 ng/mL) and with lower follicle-stimulating hormone (RR: -0.06 mIU/mL; 95% CI: -0.09, -0.03 mIU/mL). The ratio of α- to γ-tocopherol was associated with an increased risk of anovulation (RR: 1.03; 95% CI: 1.01, 1.06).
These findings shed new light on the intricate associations between serum antioxidants and endogenous hormones in healthy premenopausal women and support the hypothesis that concentrations of serum vitamins affect steroidogenesis even after adjustment for oxidative stress.</description><subject>Adolescent</subject><subject>Adult</subject><subject>alpha-Tocopherol - blood</subject><subject>Anovulation - blood</subject><subject>Antioxidants - administration & dosage</subject><subject>Ascorbic Acid - blood</subject><subject>beta Carotene - blood</subject><subject>Carotenoids - blood</subject><subject>Energy Intake</subject><subject>F2-Isoprostanes - blood</subject><subject>Female</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>gamma-Tocopherol - blood</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Lutein - blood</subject><subject>Lycopene</subject><subject>Menstrual Cycle - blood</subject><subject>Menstrual Cycle - drug effects</subject><subject>Nutritional Epidemiology</subject><subject>Ovulation - drug effects</subject><subject>Ovulation - metabolism</subject><subject>Premenopause - blood</subject><subject>Progesterone - blood</subject><subject>Prospective Studies</subject><subject>Surveys and Questionnaires</subject><subject>Testosterone - blood</subject><subject>Vitamin A - blood</subject><subject>Young Adult</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1LAzEQhoMotlaPXiV_YGuyyX7kIpSiVigU_MBjyG5m2y27SUmy1f57V1aLnoaZeecZeBC6pmTKBE9ut2ZKaTKNaZbG5ASNacJplFJCTtGYkDiOGE3TEbrwfksIoVzk52gUp0lO00yMkX4B17V4ZkJtP2utTPB45gDPvLdlrQJo_FGHDR5iz7BzVndlqPeAF9a11oDHymi82neN6hkGq364xgtQTdgc8LttwVyis0o1Hq5-6gS9Pdy_zhfRcvX4NJ8to5LlWYi4yLimqsg5pJzkjCohgMcFo6KikJWJFipWRBc80bRIK933wDkpElFxBoxN0N3A3XVFC7oEE5xq5M7VrXIHaVUt_29MvZFru5c8I0TkpAdEA6B01nsH1fGWEvmtW26N7HXLQXefv_n78Jj-9cu-AMkafkI</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Mumford, Sunni L</creator><creator>Browne, Richard W</creator><creator>Schliep, Karen C</creator><creator>Schmelzer, Jonathan</creator><creator>Plowden, Torie C</creator><creator>Michels, Kara A</creator><creator>Sjaarda, Lindsey A</creator><creator>Zarek, Shvetha M</creator><creator>Perkins, Neil J</creator><creator>Messer, Lynne C</creator><creator>Radin, Rose G</creator><creator>Wactawski-Wende, Jean</creator><creator>Schisterman, Enrique F</creator><general>American Society for Nutrition</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0539-8110</orcidid><orcidid>https://orcid.org/0000-0003-0133-3176</orcidid><orcidid>https://orcid.org/0000-0003-3757-641X</orcidid><orcidid>https://orcid.org/0000-0003-2178-6623</orcidid><orcidid>https://orcid.org/0000-0002-7332-6170</orcidid><orcidid>https://orcid.org/0000-0003-2431-2079</orcidid><orcidid>https://orcid.org/0000-0003-1771-3157</orcidid></search><sort><creationdate>20160101</creationdate><title>Serum Antioxidants Are Associated with Serum Reproductive Hormones and Ovulation among Healthy Women</title><author>Mumford, Sunni L ; Browne, Richard W ; Schliep, Karen C ; Schmelzer, Jonathan ; Plowden, Torie C ; Michels, Kara A ; Sjaarda, Lindsey A ; Zarek, Shvetha M ; Perkins, Neil J ; Messer, Lynne C ; Radin, Rose G ; Wactawski-Wende, Jean ; Schisterman, Enrique F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-4974d1ab84e640831a99e42b319f1e7c5d9a2a0db45d1b6fdd9ae440b59f43e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>alpha-Tocopherol - blood</topic><topic>Anovulation - blood</topic><topic>Antioxidants - administration & dosage</topic><topic>Ascorbic Acid - blood</topic><topic>beta Carotene - blood</topic><topic>Carotenoids - blood</topic><topic>Energy Intake</topic><topic>F2-Isoprostanes - blood</topic><topic>Female</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>gamma-Tocopherol - blood</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Lutein - blood</topic><topic>Lycopene</topic><topic>Menstrual Cycle - blood</topic><topic>Menstrual Cycle - drug effects</topic><topic>Nutritional Epidemiology</topic><topic>Ovulation - drug effects</topic><topic>Ovulation - metabolism</topic><topic>Premenopause - blood</topic><topic>Progesterone - blood</topic><topic>Prospective Studies</topic><topic>Surveys and Questionnaires</topic><topic>Testosterone - blood</topic><topic>Vitamin A - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mumford, Sunni L</creatorcontrib><creatorcontrib>Browne, Richard W</creatorcontrib><creatorcontrib>Schliep, Karen C</creatorcontrib><creatorcontrib>Schmelzer, Jonathan</creatorcontrib><creatorcontrib>Plowden, Torie C</creatorcontrib><creatorcontrib>Michels, Kara A</creatorcontrib><creatorcontrib>Sjaarda, Lindsey A</creatorcontrib><creatorcontrib>Zarek, Shvetha M</creatorcontrib><creatorcontrib>Perkins, Neil J</creatorcontrib><creatorcontrib>Messer, Lynne C</creatorcontrib><creatorcontrib>Radin, Rose G</creatorcontrib><creatorcontrib>Wactawski-Wende, Jean</creatorcontrib><creatorcontrib>Schisterman, Enrique F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mumford, Sunni L</au><au>Browne, Richard W</au><au>Schliep, Karen C</au><au>Schmelzer, Jonathan</au><au>Plowden, Torie C</au><au>Michels, Kara A</au><au>Sjaarda, Lindsey A</au><au>Zarek, Shvetha M</au><au>Perkins, Neil J</au><au>Messer, Lynne C</au><au>Radin, Rose G</au><au>Wactawski-Wende, Jean</au><au>Schisterman, Enrique F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Antioxidants Are Associated with Serum Reproductive Hormones and Ovulation among Healthy Women</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>146</volume><issue>1</issue><spage>98</spage><epage>106</epage><pages>98-106</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><abstract>Evidence is growing that the equilibrium between reactive oxygen species and antioxidants plays a vital role in women's reproductive health.
The objective of this study was to evaluate variations in serum antioxidant concentrations across the menstrual cycle and associations between antioxidants and reproductive hormones and anovulation among healthy women.
The BioCycle Study, a prospective cohort, followed 259 women aged 18-44 y for up to 2 menstrual cycles. Serum fat-soluble vitamin and micronutrient (α-tocopherol, γ-tocopherol, retinol, lutein, lycopene, and β-carotene), ascorbic acid, and reproductive hormone concentrations were measured 5-8 times/cycle. We used weighted linear mixed models to assess associations between antioxidants and hormone concentrations, after adjustment for age, race, body mass index, parity, sleep, pain medication use, total energy intake, concurrent hormones, serum cholesterol, F2-isoprostanes, and other antioxidants. Generalized linear models were used to identify associations with anovulation.
Serum antioxidant concentrations varied across the menstrual cycle. Retinol and α-tocopherol were associated with higher estradiol [RR: 1.00 pg/mL (95% CI: 0.67, 1.34 pg/mL); RR: 0.02 pg/mL (95% CI: 0.003, 0.03 pg/mL), respectively] and testosterone [RR: 0.61 ng/dL (95% CI: 0.44, 0.78 ng/dL); RR: 0.01 ng/dL (95% CI: 0.001, 0.01 ng/dL), respectively]. Ascorbic acid was associated with higher progesterone (RR: 0.15 ng/mL; 95% CI: 0.05, 0.25 ng/mL) and with lower follicle-stimulating hormone (RR: -0.06 mIU/mL; 95% CI: -0.09, -0.03 mIU/mL). The ratio of α- to γ-tocopherol was associated with an increased risk of anovulation (RR: 1.03; 95% CI: 1.01, 1.06).
These findings shed new light on the intricate associations between serum antioxidants and endogenous hormones in healthy premenopausal women and support the hypothesis that concentrations of serum vitamins affect steroidogenesis even after adjustment for oxidative stress.</abstract><cop>United States</cop><pub>American Society for Nutrition</pub><pmid>26581679</pmid><doi>10.3945/jn.115.217620</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-0539-8110</orcidid><orcidid>https://orcid.org/0000-0003-0133-3176</orcidid><orcidid>https://orcid.org/0000-0003-3757-641X</orcidid><orcidid>https://orcid.org/0000-0003-2178-6623</orcidid><orcidid>https://orcid.org/0000-0002-7332-6170</orcidid><orcidid>https://orcid.org/0000-0003-2431-2079</orcidid><orcidid>https://orcid.org/0000-0003-1771-3157</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult alpha-Tocopherol - blood Anovulation - blood Antioxidants - administration & dosage Ascorbic Acid - blood beta Carotene - blood Carotenoids - blood Energy Intake F2-Isoprostanes - blood Female Follicle Stimulating Hormone - blood gamma-Tocopherol - blood Humans Linear Models Lutein - blood Lycopene Menstrual Cycle - blood Menstrual Cycle - drug effects Nutritional Epidemiology Ovulation - drug effects Ovulation - metabolism Premenopause - blood Progesterone - blood Prospective Studies Surveys and Questionnaires Testosterone - blood Vitamin A - blood Young Adult |
| title | Serum Antioxidants Are Associated with Serum Reproductive Hormones and Ovulation among Healthy Women |
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