Daily consumption of ready-to-use peanut-based therapeutic food increased fat free mass, improved anemic status but has no impact on the zinc status of people living with HIV/AIDS: a randomized controlled trial
Food insecurity in sub-Saharan Africa and malnutrition constitute the main obstacles for successful treatment of people living with HIV/AIDS (PLWH). The aim of this study was to assess the effect of consuming daily 100 g RUTF (ready-to-use therapeutic food) as supplement, on body composition, anemia...
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| description | Food insecurity in sub-Saharan Africa and malnutrition constitute the main obstacles for successful treatment of people living with HIV/AIDS (PLWH). The aim of this study was to assess the effect of consuming daily 100 g RUTF (ready-to-use therapeutic food) as supplement, on body composition, anemia and zinc status of hospitalized PLWH in Senegal.
A Controlled clinical trial was conducted in 65 PLWH randomly allocated to receive either standard hospital diet alone (Control group: n = 33), or the standard diet supplemented with 100 g RUTF/day (RUTF group: n = 32). Supplementation was continued at home during 9 weeks. Individual dietary intakes were measured and compared to the Recommended Dietary Allowances. Body composition was determined using Bio-Impedance Analysis. Hemoglobin was measured by HemoCue and plasma zinc (PZ) concentration by atomic absorption spectrometry. PZ was adjusted to infection (CRP and α1-AGP). All measures were conducted on admission, discharge and after 9 weeks home-based follow up.
34 and 24% of the patients in RUTF and Control groups were suffering from severe malnutrition (BMI < 16 kg/m(2)), respectively. In both groups, more than 90% were anemic and zinc deficiency affected over 50% of the patients. Food consumed by the Control group represented 75, 14 and 55% of their daily recommended intake (DRI) of energy, iron and zinc, respectively. When 100 g of RUTF was consumed with the standard diet, the DRI of energy and zinc were 100% covered (2147 kcal, 10.4 mg, respectively), but not iron (2.9 mg). After 9 weeks of supplementation, body weight, and fat-free mass increased significantly by +11% (p = 0.033), and +11.8% (p = 0.033) in the RUTF group, but not in the Control group, while percentage body fat was comparable between groups (p = 0.888). In the RUTF group, fat free mass gain is higher in the patients on ART (+11.7%, n = 14; p = 0.0001) than in those without ART (+6.2%, n = 6; p = 0.032). Anemia decreased significantly with the supplementation, but zinc status, measured using plasma zinc concentration, remained unchanged.
Improving PLWH' diet with 100 g RUTF for a long period has a positive impact on muscle mass and anemia but not on the zinc status of the patients.
NCT02433743, registered 29 April 2015. |
| doi_str_mv | 10.1186/s12889-015-2639-8 |
| format | Article |
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A Controlled clinical trial was conducted in 65 PLWH randomly allocated to receive either standard hospital diet alone (Control group: n = 33), or the standard diet supplemented with 100 g RUTF/day (RUTF group: n = 32). Supplementation was continued at home during 9 weeks. Individual dietary intakes were measured and compared to the Recommended Dietary Allowances. Body composition was determined using Bio-Impedance Analysis. Hemoglobin was measured by HemoCue and plasma zinc (PZ) concentration by atomic absorption spectrometry. PZ was adjusted to infection (CRP and α1-AGP). All measures were conducted on admission, discharge and after 9 weeks home-based follow up.
34 and 24% of the patients in RUTF and Control groups were suffering from severe malnutrition (BMI < 16 kg/m(2)), respectively. In both groups, more than 90% were anemic and zinc deficiency affected over 50% of the patients. Food consumed by the Control group represented 75, 14 and 55% of their daily recommended intake (DRI) of energy, iron and zinc, respectively. When 100 g of RUTF was consumed with the standard diet, the DRI of energy and zinc were 100% covered (2147 kcal, 10.4 mg, respectively), but not iron (2.9 mg). After 9 weeks of supplementation, body weight, and fat-free mass increased significantly by +11% (p = 0.033), and +11.8% (p = 0.033) in the RUTF group, but not in the Control group, while percentage body fat was comparable between groups (p = 0.888). In the RUTF group, fat free mass gain is higher in the patients on ART (+11.7%, n = 14; p = 0.0001) than in those without ART (+6.2%, n = 6; p = 0.032). Anemia decreased significantly with the supplementation, but zinc status, measured using plasma zinc concentration, remained unchanged.
Improving PLWH' diet with 100 g RUTF for a long period has a positive impact on muscle mass and anemia but not on the zinc status of the patients.
NCT02433743, registered 29 April 2015.</description><identifier>ISSN: 1471-2458</identifier><identifier>EISSN: 1471-2458</identifier><identifier>DOI: 10.1186/s12889-015-2639-8</identifier><identifier>PMID: 26728978</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Acquired immune deficiency syndrome ; Acquired Immunodeficiency Syndrome - blood ; Acquired Immunodeficiency Syndrome - complications ; Adult ; AIDS ; Anemia ; Anemia - diet therapy ; Anemia - epidemiology ; Antiretroviral therapy ; Arachis ; Atomic absorption analysis ; Atomic absorption spectroscopy ; Body Composition ; Body fat ; Body Fluid Compartments - metabolism ; Body weight ; Care and treatment ; Chemical compounds ; Complications and side effects ; Control methods ; Development and progression ; Diet ; Dietary Supplements ; Direct reduced iron ; Disease ; Energy Intake ; Fat-free body mass ; Female ; Food ; Food intake ; Food security ; Food, Fortified ; Hemoglobin ; Hemoglobins - metabolism ; HIV ; HIV Infections - blood ; HIV Infections - complications ; Hospitalization ; Hospitals ; Human immunodeficiency virus ; Humans ; Infections ; Iron ; Iron, Dietary - administration & dosage ; Iron, Dietary - pharmacology ; Male ; Malnutrition ; Malnutrition - diet therapy ; Malnutrition - epidemiology ; Meals ; Middle Aged ; Mortality ; Muscles ; Nutrient deficiency ; Nuts ; Patients ; Peanuts ; Pharmaceuticals ; Public health ; Recommended Dietary Allowances ; Rice ; Senegal - epidemiology ; Spectral analysis ; Spectrometry ; Thinness - diet therapy ; Thinness - epidemiology ; Zinc ; Zinc - administration & dosage ; Zinc - blood ; Zinc - pharmacology</subject><ispartof>BMC public health, 2016-01, Vol.16 (2), p.1-1, Article 1</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>2016. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Diouf et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-c73c4889b2edf4af0ac7f4338d646a64764f3d9bbad99688d57ce2b7b4f36d853</citedby><cites>FETCH-LOGICAL-c522t-c73c4889b2edf4af0ac7f4338d646a64764f3d9bbad99688d57ce2b7b4f36d853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700615/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700615/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26728978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Diouf, Adama</creatorcontrib><creatorcontrib>Badiane, Abdou</creatorcontrib><creatorcontrib>Manga, Noël Magloire</creatorcontrib><creatorcontrib>Idohou-Dossou, Nicole</creatorcontrib><creatorcontrib>Sow, Papa Salif</creatorcontrib><creatorcontrib>Wade, Salimata</creatorcontrib><title>Daily consumption of ready-to-use peanut-based therapeutic food increased fat free mass, improved anemic status but has no impact on the zinc status of people living with HIV/AIDS: a randomized controlled trial</title><title>BMC public health</title><addtitle>BMC Public Health</addtitle><description>Food insecurity in sub-Saharan Africa and malnutrition constitute the main obstacles for successful treatment of people living with HIV/AIDS (PLWH). The aim of this study was to assess the effect of consuming daily 100 g RUTF (ready-to-use therapeutic food) as supplement, on body composition, anemia and zinc status of hospitalized PLWH in Senegal.
A Controlled clinical trial was conducted in 65 PLWH randomly allocated to receive either standard hospital diet alone (Control group: n = 33), or the standard diet supplemented with 100 g RUTF/day (RUTF group: n = 32). Supplementation was continued at home during 9 weeks. Individual dietary intakes were measured and compared to the Recommended Dietary Allowances. Body composition was determined using Bio-Impedance Analysis. Hemoglobin was measured by HemoCue and plasma zinc (PZ) concentration by atomic absorption spectrometry. PZ was adjusted to infection (CRP and α1-AGP). All measures were conducted on admission, discharge and after 9 weeks home-based follow up.
34 and 24% of the patients in RUTF and Control groups were suffering from severe malnutrition (BMI < 16 kg/m(2)), respectively. In both groups, more than 90% were anemic and zinc deficiency affected over 50% of the patients. Food consumed by the Control group represented 75, 14 and 55% of their daily recommended intake (DRI) of energy, iron and zinc, respectively. When 100 g of RUTF was consumed with the standard diet, the DRI of energy and zinc were 100% covered (2147 kcal, 10.4 mg, respectively), but not iron (2.9 mg). After 9 weeks of supplementation, body weight, and fat-free mass increased significantly by +11% (p = 0.033), and +11.8% (p = 0.033) in the RUTF group, but not in the Control group, while percentage body fat was comparable between groups (p = 0.888). In the RUTF group, fat free mass gain is higher in the patients on ART (+11.7%, n = 14; p = 0.0001) than in those without ART (+6.2%, n = 6; p = 0.032). Anemia decreased significantly with the supplementation, but zinc status, measured using plasma zinc concentration, remained unchanged.
Improving PLWH' diet with 100 g RUTF for a long period has a positive impact on muscle mass and anemia but not on the zinc status of the patients.
NCT02433743, registered 29 April 2015.</description><subject>Acquired immune deficiency syndrome</subject><subject>Acquired Immunodeficiency Syndrome - blood</subject><subject>Acquired Immunodeficiency Syndrome - complications</subject><subject>Adult</subject><subject>AIDS</subject><subject>Anemia</subject><subject>Anemia - diet therapy</subject><subject>Anemia - epidemiology</subject><subject>Antiretroviral therapy</subject><subject>Arachis</subject><subject>Atomic absorption analysis</subject><subject>Atomic absorption spectroscopy</subject><subject>Body Composition</subject><subject>Body fat</subject><subject>Body Fluid Compartments - metabolism</subject><subject>Body weight</subject><subject>Care and treatment</subject><subject>Chemical compounds</subject><subject>Complications and side effects</subject><subject>Control methods</subject><subject>Development and progression</subject><subject>Diet</subject><subject>Dietary Supplements</subject><subject>Direct reduced iron</subject><subject>Disease</subject><subject>Energy Intake</subject><subject>Fat-free body mass</subject><subject>Female</subject><subject>Food</subject><subject>Food intake</subject><subject>Food security</subject><subject>Food, Fortified</subject><subject>Hemoglobin</subject><subject>Hemoglobins - metabolism</subject><subject>HIV</subject><subject>HIV Infections - blood</subject><subject>HIV Infections - complications</subject><subject>Hospitalization</subject><subject>Hospitals</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infections</subject><subject>Iron</subject><subject>Iron, Dietary - administration & dosage</subject><subject>Iron, Dietary - pharmacology</subject><subject>Male</subject><subject>Malnutrition</subject><subject>Malnutrition - diet therapy</subject><subject>Malnutrition - epidemiology</subject><subject>Meals</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Muscles</subject><subject>Nutrient deficiency</subject><subject>Nuts</subject><subject>Patients</subject><subject>Peanuts</subject><subject>Pharmaceuticals</subject><subject>Public health</subject><subject>Recommended Dietary Allowances</subject><subject>Rice</subject><subject>Senegal - epidemiology</subject><subject>Spectral analysis</subject><subject>Spectrometry</subject><subject>Thinness - diet therapy</subject><subject>Thinness - epidemiology</subject><subject>Zinc</subject><subject>Zinc - administration & dosage</subject><subject>Zinc - blood</subject><subject>Zinc - pharmacology</subject><issn>1471-2458</issn><issn>1471-2458</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kstu1DAUhiMEoqXwAGyQJTYsSBtfEjsskEYt0JEqseCytRxfZlw5drCdQe1j8kQ4mra0CCEvYh1_5_ef47-qXsLmGELWnSSIGOvrBrY16nBfs0fVISQU1oi07PG9_UH1LKXLpoGUtehpdYA6ilhP2WH160xYdwVk8Gkep2yDB8GAqIW6qnOo56TBpIWfcz2IpBXIWx3FpOdsJTAhKGC9LPRyZEQGJmoNRpHSW2DHKYZdqQuvx0KnLPKcwDBnsBUJ-LAQQmZQriyq4Loo3ULFwqTD5DRwdmf9Bvy0eQvO199PVuuzL--AAFF4FUZ7XfSL9xyDc4u7aIV7Xj0xwiX94uZ7VH37-OHr6Xl98fnT-nR1UcsWoVxLiiUp4xuQVoYI0whJDcGYqY50oiO0IwarfhiE6vuOMdVSqdFAh1LuFGvxUfV-rzvNw6iV1MWGcHyKdhTxigdh-cMTb7d8E3ac0Kbp4CLw5kYghh-zTpmPNkntXJlYmBOHtCVNj3tECvr6L_QyzNGX3-MIE0Zg8dz-j4KUkvL-qMd_qI1wmltvQnEnl6v5irQQt4xhVKjjf1BlqeU1g9fGlvqDBrhvkDGkFLW5mwRs-BJXvo8rL3HlS1w5Kz2v7o_wruM2n_g3cH_ohQ</recordid><startdate>20160104</startdate><enddate>20160104</enddate><creator>Diouf, Adama</creator><creator>Badiane, Abdou</creator><creator>Manga, Noël Magloire</creator><creator>Idohou-Dossou, Nicole</creator><creator>Sow, Papa Salif</creator><creator>Wade, Salimata</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>PATMY</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160104</creationdate><title>Daily consumption of ready-to-use peanut-based therapeutic food increased fat free mass, improved anemic status but has no impact on the zinc status of people living with HIV/AIDS: a randomized controlled trial</title><author>Diouf, Adama ; Badiane, Abdou ; Manga, Noël Magloire ; Idohou-Dossou, Nicole ; Sow, Papa Salif ; Wade, Salimata</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-c73c4889b2edf4af0ac7f4338d646a64764f3d9bbad99688d57ce2b7b4f36d853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Acquired Immunodeficiency Syndrome - blood</topic><topic>Acquired Immunodeficiency Syndrome - complications</topic><topic>Adult</topic><topic>AIDS</topic><topic>Anemia</topic><topic>Anemia - diet therapy</topic><topic>Anemia - epidemiology</topic><topic>Antiretroviral therapy</topic><topic>Arachis</topic><topic>Atomic absorption analysis</topic><topic>Atomic absorption spectroscopy</topic><topic>Body Composition</topic><topic>Body fat</topic><topic>Body Fluid Compartments - metabolism</topic><topic>Body weight</topic><topic>Care and treatment</topic><topic>Chemical compounds</topic><topic>Complications and side effects</topic><topic>Control methods</topic><topic>Development and progression</topic><topic>Diet</topic><topic>Dietary Supplements</topic><topic>Direct reduced iron</topic><topic>Disease</topic><topic>Energy Intake</topic><topic>Fat-free body mass</topic><topic>Female</topic><topic>Food</topic><topic>Food intake</topic><topic>Food security</topic><topic>Food, Fortified</topic><topic>Hemoglobin</topic><topic>Hemoglobins - metabolism</topic><topic>HIV</topic><topic>HIV Infections - blood</topic><topic>HIV Infections - complications</topic><topic>Hospitalization</topic><topic>Hospitals</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Infections</topic><topic>Iron</topic><topic>Iron, Dietary - administration & dosage</topic><topic>Iron, Dietary - pharmacology</topic><topic>Male</topic><topic>Malnutrition</topic><topic>Malnutrition - diet therapy</topic><topic>Malnutrition - epidemiology</topic><topic>Meals</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Muscles</topic><topic>Nutrient deficiency</topic><topic>Nuts</topic><topic>Patients</topic><topic>Peanuts</topic><topic>Pharmaceuticals</topic><topic>Public health</topic><topic>Recommended Dietary Allowances</topic><topic>Rice</topic><topic>Senegal - epidemiology</topic><topic>Spectral analysis</topic><topic>Spectrometry</topic><topic>Thinness - diet therapy</topic><topic>Thinness - epidemiology</topic><topic>Zinc</topic><topic>Zinc - administration & dosage</topic><topic>Zinc - blood</topic><topic>Zinc - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diouf, Adama</creatorcontrib><creatorcontrib>Badiane, Abdou</creatorcontrib><creatorcontrib>Manga, Noël Magloire</creatorcontrib><creatorcontrib>Idohou-Dossou, Nicole</creatorcontrib><creatorcontrib>Sow, Papa Salif</creatorcontrib><creatorcontrib>Wade, Salimata</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Engineering Database</collection><collection>Environmental Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diouf, Adama</au><au>Badiane, Abdou</au><au>Manga, Noël Magloire</au><au>Idohou-Dossou, Nicole</au><au>Sow, Papa Salif</au><au>Wade, Salimata</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Daily consumption of ready-to-use peanut-based therapeutic food increased fat free mass, improved anemic status but has no impact on the zinc status of people living with HIV/AIDS: a randomized controlled trial</atitle><jtitle>BMC public health</jtitle><addtitle>BMC Public Health</addtitle><date>2016-01-04</date><risdate>2016</risdate><volume>16</volume><issue>2</issue><spage>1</spage><epage>1</epage><pages>1-1</pages><artnum>1</artnum><issn>1471-2458</issn><eissn>1471-2458</eissn><abstract>Food insecurity in sub-Saharan Africa and malnutrition constitute the main obstacles for successful treatment of people living with HIV/AIDS (PLWH). The aim of this study was to assess the effect of consuming daily 100 g RUTF (ready-to-use therapeutic food) as supplement, on body composition, anemia and zinc status of hospitalized PLWH in Senegal.
A Controlled clinical trial was conducted in 65 PLWH randomly allocated to receive either standard hospital diet alone (Control group: n = 33), or the standard diet supplemented with 100 g RUTF/day (RUTF group: n = 32). Supplementation was continued at home during 9 weeks. Individual dietary intakes were measured and compared to the Recommended Dietary Allowances. Body composition was determined using Bio-Impedance Analysis. Hemoglobin was measured by HemoCue and plasma zinc (PZ) concentration by atomic absorption spectrometry. PZ was adjusted to infection (CRP and α1-AGP). All measures were conducted on admission, discharge and after 9 weeks home-based follow up.
34 and 24% of the patients in RUTF and Control groups were suffering from severe malnutrition (BMI < 16 kg/m(2)), respectively. In both groups, more than 90% were anemic and zinc deficiency affected over 50% of the patients. Food consumed by the Control group represented 75, 14 and 55% of their daily recommended intake (DRI) of energy, iron and zinc, respectively. When 100 g of RUTF was consumed with the standard diet, the DRI of energy and zinc were 100% covered (2147 kcal, 10.4 mg, respectively), but not iron (2.9 mg). After 9 weeks of supplementation, body weight, and fat-free mass increased significantly by +11% (p = 0.033), and +11.8% (p = 0.033) in the RUTF group, but not in the Control group, while percentage body fat was comparable between groups (p = 0.888). In the RUTF group, fat free mass gain is higher in the patients on ART (+11.7%, n = 14; p = 0.0001) than in those without ART (+6.2%, n = 6; p = 0.032). Anemia decreased significantly with the supplementation, but zinc status, measured using plasma zinc concentration, remained unchanged.
Improving PLWH' diet with 100 g RUTF for a long period has a positive impact on muscle mass and anemia but not on the zinc status of the patients.
NCT02433743, registered 29 April 2015.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>26728978</pmid><doi>10.1186/s12889-015-2639-8</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4700615 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Springer Nature OA Free Journals |
| subjects | Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - blood Acquired Immunodeficiency Syndrome - complications Adult AIDS Anemia Anemia - diet therapy Anemia - epidemiology Antiretroviral therapy Arachis Atomic absorption analysis Atomic absorption spectroscopy Body Composition Body fat Body Fluid Compartments - metabolism Body weight Care and treatment Chemical compounds Complications and side effects Control methods Development and progression Diet Dietary Supplements Direct reduced iron Disease Energy Intake Fat-free body mass Female Food Food intake Food security Food, Fortified Hemoglobin Hemoglobins - metabolism HIV HIV Infections - blood HIV Infections - complications Hospitalization Hospitals Human immunodeficiency virus Humans Infections Iron Iron, Dietary - administration & dosage Iron, Dietary - pharmacology Male Malnutrition Malnutrition - diet therapy Malnutrition - epidemiology Meals Middle Aged Mortality Muscles Nutrient deficiency Nuts Patients Peanuts Pharmaceuticals Public health Recommended Dietary Allowances Rice Senegal - epidemiology Spectral analysis Spectrometry Thinness - diet therapy Thinness - epidemiology Zinc Zinc - administration & dosage Zinc - blood Zinc - pharmacology |
| title | Daily consumption of ready-to-use peanut-based therapeutic food increased fat free mass, improved anemic status but has no impact on the zinc status of people living with HIV/AIDS: a randomized controlled trial |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T01%3A33%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Daily%20consumption%20of%20ready-to-use%20peanut-based%20therapeutic%20food%20increased%20fat%20free%20mass,%20improved%20anemic%20status%20but%20has%20no%20impact%20on%20the%20zinc%20status%20of%20people%20living%20with%20HIV/AIDS:%20a%20randomized%20controlled%20trial&rft.jtitle=BMC%20public%20health&rft.au=Diouf,%20Adama&rft.date=2016-01-04&rft.volume=16&rft.issue=2&rft.spage=1&rft.epage=1&rft.pages=1-1&rft.artnum=1&rft.issn=1471-2458&rft.eissn=1471-2458&rft_id=info:doi/10.1186/s12889-015-2639-8&rft_dat=%3Cgale_pubme%3EA451358832%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1774001293&rft_id=info:pmid/26728978&rft_galeid=A451358832&rfr_iscdi=true |