Dynamics of Fluoride Bioavailability in the Biofilms of Different Oral Surfaces after Amine Fluoride and Sodium Fluoride Application
It was the aim of this study to investigate differences in fluoride bioavailability in different oral areas after the application of amine fluoride (AmF) and sodium fluoride (NaF). The null hypothesis suggested no differences in the fluoride bioavailability. The tongue coating was removed and biofil...
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| Veröffentlicht in: | Scientific reports 2016-01, Vol.6 (1), p.18729-18729, Article 18729 |
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| creator | Naumova, Ella A. Dickten, Christoph Jung, Rico Krauss, Florian Rübesamen, Henrik Schmütsch, Katharina Sandulescu, Tudor Zimmer, Stefan Arnold, Wolfgang H. |
| description | It was the aim of this study to investigate differences in fluoride bioavailability in different oral areas after the application of amine fluoride (AmF) and sodium fluoride (NaF). The null hypothesis suggested no differences in the fluoride bioavailability. The tongue coating was removed and biofilm samples from the palate, oral floor and cheeks were collected. All subjects brushed their teeth with toothpaste containing AmF or NaF. Specimens were collected before, as well as immediately after and at 30 and 120 minutes after tooth brushing. The fluoride concentration was determined. The area under the curve was calculated for each location and compared statistically. In the tongue coating, fluoride concentration increased faster after NaF application than after AmF application. After 30 minutes, the fluoride concentration decreased and remained stable until 120 minutes after AmF application and returned to baseline after NaF application. The difference between the baseline and the endpoint measurements was statistically significant. The fluoride concentration in the tongue coating remained at a higher level compared with the baseline for up to 120 minutes post-brushing. This may indicate that the tongue coating is a major reservoir for fluoride bioavailability. The results also indicate an unequal fluoride distribution in the oral cavity. |
| doi_str_mv | 10.1038/srep18729 |
| format | Article |
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The null hypothesis suggested no differences in the fluoride bioavailability. The tongue coating was removed and biofilm samples from the palate, oral floor and cheeks were collected. All subjects brushed their teeth with toothpaste containing AmF or NaF. Specimens were collected before, as well as immediately after and at 30 and 120 minutes after tooth brushing. The fluoride concentration was determined. The area under the curve was calculated for each location and compared statistically. In the tongue coating, fluoride concentration increased faster after NaF application than after AmF application. After 30 minutes, the fluoride concentration decreased and remained stable until 120 minutes after AmF application and returned to baseline after NaF application. The difference between the baseline and the endpoint measurements was statistically significant. The fluoride concentration in the tongue coating remained at a higher level compared with the baseline for up to 120 minutes post-brushing. This may indicate that the tongue coating is a major reservoir for fluoride bioavailability. The results also indicate an unequal fluoride distribution in the oral cavity.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep18729</identifier><identifier>PMID: 26727989</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>101/62 ; 14/34 ; 692/700 ; 692/700/3032 ; Adult ; Bioavailability ; Biofilms ; Biofilms - drug effects ; Cheek ; Dentifrices ; Female ; Fluoridation ; Fluoride treatments ; Fluorides ; Fluorides, Topical - pharmacology ; Humanities and Social Sciences ; Humans ; Male ; Microbial Viability - drug effects ; Mouth Mucosa - microbiology ; multidisciplinary ; Oral cavity ; Palate ; Saliva - microbiology ; Science ; Sodium ; Sodium fluoride ; Sodium Fluoride - pharmacology ; Statistical analysis ; Teeth ; Time Factors ; Tongue ; Toothbrushing ; Young Adult</subject><ispartof>Scientific reports, 2016-01, Vol.6 (1), p.18729-18729, Article 18729</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Jan 2016</rights><rights>Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-b60939a89255b3549ebc807a04b9f9c3e4b674631488911761ea42f40bf5f4003</citedby><cites>FETCH-LOGICAL-c438t-b60939a89255b3549ebc807a04b9f9c3e4b674631488911761ea42f40bf5f4003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700523/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700523/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,27907,27908,41103,42172,51559,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26727989$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Naumova, Ella A.</creatorcontrib><creatorcontrib>Dickten, Christoph</creatorcontrib><creatorcontrib>Jung, Rico</creatorcontrib><creatorcontrib>Krauss, Florian</creatorcontrib><creatorcontrib>Rübesamen, Henrik</creatorcontrib><creatorcontrib>Schmütsch, Katharina</creatorcontrib><creatorcontrib>Sandulescu, Tudor</creatorcontrib><creatorcontrib>Zimmer, Stefan</creatorcontrib><creatorcontrib>Arnold, Wolfgang H.</creatorcontrib><title>Dynamics of Fluoride Bioavailability in the Biofilms of Different Oral Surfaces after Amine Fluoride and Sodium Fluoride Application</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>It was the aim of this study to investigate differences in fluoride bioavailability in different oral areas after the application of amine fluoride (AmF) and sodium fluoride (NaF). The null hypothesis suggested no differences in the fluoride bioavailability. The tongue coating was removed and biofilm samples from the palate, oral floor and cheeks were collected. All subjects brushed their teeth with toothpaste containing AmF or NaF. Specimens were collected before, as well as immediately after and at 30 and 120 minutes after tooth brushing. The fluoride concentration was determined. The area under the curve was calculated for each location and compared statistically. In the tongue coating, fluoride concentration increased faster after NaF application than after AmF application. After 30 minutes, the fluoride concentration decreased and remained stable until 120 minutes after AmF application and returned to baseline after NaF application. The difference between the baseline and the endpoint measurements was statistically significant. The fluoride concentration in the tongue coating remained at a higher level compared with the baseline for up to 120 minutes post-brushing. This may indicate that the tongue coating is a major reservoir for fluoride bioavailability. The results also indicate an unequal fluoride distribution in the oral cavity.</description><subject>101/62</subject><subject>14/34</subject><subject>692/700</subject><subject>692/700/3032</subject><subject>Adult</subject><subject>Bioavailability</subject><subject>Biofilms</subject><subject>Biofilms - drug effects</subject><subject>Cheek</subject><subject>Dentifrices</subject><subject>Female</subject><subject>Fluoridation</subject><subject>Fluoride treatments</subject><subject>Fluorides</subject><subject>Fluorides, Topical - pharmacology</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Male</subject><subject>Microbial Viability - drug effects</subject><subject>Mouth Mucosa - microbiology</subject><subject>multidisciplinary</subject><subject>Oral cavity</subject><subject>Palate</subject><subject>Saliva - microbiology</subject><subject>Science</subject><subject>Sodium</subject><subject>Sodium fluoride</subject><subject>Sodium Fluoride - pharmacology</subject><subject>Statistical analysis</subject><subject>Teeth</subject><subject>Time Factors</subject><subject>Tongue</subject><subject>Toothbrushing</subject><subject>Young Adult</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkU9PFTEUxRsjEYIs-AKmiRs1edp_M9NuTJ4gSkLCAlk3nb4WLum0YztD8vZ-cAsPH0_tom3u_eXc0x6Ejin5SAmXn0p2I5UdUy_QASOiWTDO2Mud-z46KuWO1NUwJah6hfZZ27FOSXWAfp2uoxnAFpw8PgtzyrBy-Askc28gmB4CTGsMEU-3j2UPYXhkT8F7l12c8GU2AV_N2RvrCjZ-chkvB4juWc_EFb5KK5iH59pyHANYM0GKr9GeN6G4o6fzEF2fff1x8n1xcfnt_GR5sbCCy2nRt0RxZaRiTdPzRijXW0k6Q0SvvLLcib7tRMupkFJR2rXUGcG8IL1v6k74Ifq80R3nfnArW91X73rMMJi81smA_rsT4VbfpHstuofP41Xg3ZNATj9nVyY9QLEuBBNdmoumXSOIbAkXFX37D3qX5hzr8zSVStXkWsIq9X5D2ZxKTdJvzVCiH-LV23gr-2bX_Zb8E2YFPmyAUlvxxuWdkf-p_QYh_a-E</recordid><startdate>20160105</startdate><enddate>20160105</enddate><creator>Naumova, Ella A.</creator><creator>Dickten, Christoph</creator><creator>Jung, Rico</creator><creator>Krauss, Florian</creator><creator>Rübesamen, Henrik</creator><creator>Schmütsch, Katharina</creator><creator>Sandulescu, Tudor</creator><creator>Zimmer, Stefan</creator><creator>Arnold, Wolfgang H.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160105</creationdate><title>Dynamics of Fluoride Bioavailability in the Biofilms of Different Oral Surfaces after Amine Fluoride and Sodium Fluoride Application</title><author>Naumova, Ella A. ; Dickten, Christoph ; Jung, Rico ; Krauss, Florian ; Rübesamen, Henrik ; Schmütsch, Katharina ; Sandulescu, Tudor ; Zimmer, Stefan ; Arnold, Wolfgang H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-b60939a89255b3549ebc807a04b9f9c3e4b674631488911761ea42f40bf5f4003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>101/62</topic><topic>14/34</topic><topic>692/700</topic><topic>692/700/3032</topic><topic>Adult</topic><topic>Bioavailability</topic><topic>Biofilms</topic><topic>Biofilms - drug effects</topic><topic>Cheek</topic><topic>Dentifrices</topic><topic>Female</topic><topic>Fluoridation</topic><topic>Fluoride treatments</topic><topic>Fluorides</topic><topic>Fluorides, Topical - pharmacology</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Male</topic><topic>Microbial Viability - drug effects</topic><topic>Mouth Mucosa - microbiology</topic><topic>multidisciplinary</topic><topic>Oral cavity</topic><topic>Palate</topic><topic>Saliva - microbiology</topic><topic>Science</topic><topic>Sodium</topic><topic>Sodium fluoride</topic><topic>Sodium Fluoride - pharmacology</topic><topic>Statistical analysis</topic><topic>Teeth</topic><topic>Time Factors</topic><topic>Tongue</topic><topic>Toothbrushing</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Naumova, Ella A.</creatorcontrib><creatorcontrib>Dickten, Christoph</creatorcontrib><creatorcontrib>Jung, Rico</creatorcontrib><creatorcontrib>Krauss, Florian</creatorcontrib><creatorcontrib>Rübesamen, Henrik</creatorcontrib><creatorcontrib>Schmütsch, Katharina</creatorcontrib><creatorcontrib>Sandulescu, Tudor</creatorcontrib><creatorcontrib>Zimmer, Stefan</creatorcontrib><creatorcontrib>Arnold, Wolfgang H.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Naumova, Ella A.</au><au>Dickten, Christoph</au><au>Jung, Rico</au><au>Krauss, Florian</au><au>Rübesamen, Henrik</au><au>Schmütsch, Katharina</au><au>Sandulescu, Tudor</au><au>Zimmer, Stefan</au><au>Arnold, Wolfgang H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamics of Fluoride Bioavailability in the Biofilms of Different Oral Surfaces after Amine Fluoride and Sodium Fluoride Application</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-01-05</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>18729</spage><epage>18729</epage><pages>18729-18729</pages><artnum>18729</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>It was the aim of this study to investigate differences in fluoride bioavailability in different oral areas after the application of amine fluoride (AmF) and sodium fluoride (NaF). The null hypothesis suggested no differences in the fluoride bioavailability. The tongue coating was removed and biofilm samples from the palate, oral floor and cheeks were collected. All subjects brushed their teeth with toothpaste containing AmF or NaF. Specimens were collected before, as well as immediately after and at 30 and 120 minutes after tooth brushing. The fluoride concentration was determined. The area under the curve was calculated for each location and compared statistically. In the tongue coating, fluoride concentration increased faster after NaF application than after AmF application. After 30 minutes, the fluoride concentration decreased and remained stable until 120 minutes after AmF application and returned to baseline after NaF application. The difference between the baseline and the endpoint measurements was statistically significant. The fluoride concentration in the tongue coating remained at a higher level compared with the baseline for up to 120 minutes post-brushing. This may indicate that the tongue coating is a major reservoir for fluoride bioavailability. The results also indicate an unequal fluoride distribution in the oral cavity.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26727989</pmid><doi>10.1038/srep18729</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 101/62 14/34 692/700 692/700/3032 Adult Bioavailability Biofilms Biofilms - drug effects Cheek Dentifrices Female Fluoridation Fluoride treatments Fluorides Fluorides, Topical - pharmacology Humanities and Social Sciences Humans Male Microbial Viability - drug effects Mouth Mucosa - microbiology multidisciplinary Oral cavity Palate Saliva - microbiology Science Sodium Sodium fluoride Sodium Fluoride - pharmacology Statistical analysis Teeth Time Factors Tongue Toothbrushing Young Adult |
| title | Dynamics of Fluoride Bioavailability in the Biofilms of Different Oral Surfaces after Amine Fluoride and Sodium Fluoride Application |
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