Aspirin and atenolol enhance metformin activity against breast cancer by targeting both neoplastic and microenvironment cells

Metformin can induce breast cancer (BC) cell apoptosis and reduce BC local and metastatic growth in preclinical models. Since Metformin is frequently used along with Aspirin or beta-blockers, we investigated the effect of Metformin, Aspirin and the beta-blocker Atenolol in several BC models. In vitr...

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Veröffentlicht in:	Scientific reports 2016-01, Vol.6 (1), p.18673-18673, Article 18673
Hauptverfasser:	Talarico, Giovanna, Orecchioni, Stefania, Dallaglio, Katiuscia, Reggiani, Francesca, Mancuso, Patrizia, Calleri, Angelica, Gregato, Giuliana, Labanca, Valentina, Rossi, Teresa, Noonan, Douglas M., Albini, Adriana, Bertolini, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/31 13/51 59 631/67/2328 631/67/327 64 64/60 Adipose tissue Adipose Tissue, White - drug effects Adipose Tissue, White - metabolism AMP-Activated Protein Kinases - metabolism Angiogenesis Animals Antidiabetics Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Aspirin Aspirin - pharmacology Atenolol Atenolol - pharmacology Biomarkers, Tumor Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Disease Models, Animal Drug Synergism Electron transport Electron transport chain Electron Transport Complex I - metabolism ErbB-2 protein Female Humanities and Social Sciences Humans Metastases Metastasis Metformin Metformin - pharmacology multidisciplinary NAD - metabolism Neoplasm Metastasis Pericytes Science Stem Cells - drug effects Stem Cells - metabolism Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology Tumor Burden - drug effects Tumor Microenvironment - drug effects Xenograft Model Antitumor Assays
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