Inhibition of Aggregation of Mutant Huntingtin by Nucleic Acid Aptamers In Vitro and in a Yeast Model of Huntington's Disease

Elongated polyglutamine stretch in mutant huntingtin (mhtt) correlates well with the pathology of Huntington's disease (HD). Inhibition of aggregation of mhtt is a promising strategy to arrest disease progression. In this work, specific, high-affinity RNA aptamers were selected against monomeri...

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Veröffentlicht in:	Molecular therapy 2015-12, Vol.23 (12), p.1912-1926
Hauptverfasser:	Chaudhary, Rajeev K, Patel, Kinjal A, Patel, Milan K, Joshi, Radha H, Roy, Ipsita
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates Antibodies Aptamers, Nucleotide - chemistry Aptamers, Nucleotide - genetics Base Sequence Cellulose acetate Glyceraldehyde-3-Phosphate Dehydrogenases - chemistry Glyceraldehyde-3-Phosphate Dehydrogenases - genetics Humans Huntingtin Protein Huntington Disease - genetics Huntingtons disease Molecular Sequence Data Mutant Proteins - chemistry Mutant Proteins - genetics Mutation Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - genetics Nucleic Acid Conformation Nucleic Acids - chemistry Original Oxidative Stress Peptides - chemistry Pharmaceutical sciences Proteins Saccharomyces cerevisiae - genetics Sequence Analysis, RNA Spectrum analysis
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