MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer’s disease

Membrane-type 5-matrix metalloproteinase (MT5-MMP) is a proteinase mainly expressed in the nervous system with emerging roles in brain pathophysiology. The implication of MT5-MMP in Alzheimer’s disease (AD), notably its interplay with the amyloidogenic process, remains elusive. Accordingly, we cross...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2016-01, Vol.73 (1), p.217-236
Hauptverfasser:	Baranger, Kévin, Marchalant, Yannick, Bonnet, Amandine E, Crouzin, Nadine, Carrete, Alex, Paumier, Jean-Michel, Py, Nathalie A, Bernard, Anne, Bauer, Charlotte, Charrat, Eliane, Moschke, Katrin, Seiki, Mothoharu, Vignes, Michel, Lichtenthaler, Stefan F, Checler, Frédéric, Khrestchatisky, Michel, Rivera, Santiago
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer disease Alzheimer Disease - enzymology Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer's disease amyloid Amyloid beta-Peptides - analysis Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - analysis Amyloid beta-Protein Precursor - metabolism Amyloid Precursor Protein Secretases - analysis Amyloid Precursor Protein Secretases - metabolism amyloidosis animal models Animals Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Cognition Cognitive ability cortex Female Gene Deletion HEK293 Cells hippocampus Hippocampus - enzymology Hippocampus - metabolism Hippocampus - pathology Hippocampus - physiopathology Humans interleukin-1beta learning Life Sciences Long-Term Potentiation Male Matrix Metalloproteinases, Membrane-Associated - analysis Matrix Metalloproteinases, Membrane-Associated - genetics Matrix Metalloproteinases, Membrane-Associated - metabolism Membranes metabolism mice Mice, Inbred C57BL Mice, Transgenic Nervous system neural networks Neurobiology Neurons and Cognition Pathology pathophysiology Peptides proteinases Proteins Research Article Spatial Learning transgenic animals
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