Oxytocin in the nucleus accumbens shell reverses CRFR2-evoked passive stress-coping after partner loss in monogamous male prairie voles

Highlights • Male prairie voles show high passive stress-coping after loss of female partner. • This is mediated via activation of CRFR2 in nucleus accumbens shell. • Chronic activation of CRFR2 is capable of impairing the oxytocin system. • The oxytocin system gets compromised at multiple levels. •...

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Veröffentlicht in:	Psychoneuroendocrinology 2016-02, Vol.64, p.66-78
Hauptverfasser:	Bosch, Oliver J, Dabrowska, Joanna, Modi, Meera E, Johnson, Zachary V, Keebaugh, Alaine C, Barrett, Catherine E, Ahern, Todd H, Guo, JiDong, Grinevich, Valery, Rainnie, Donald G, Neumann, Inga D, Young, Larry J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Psychological Animals Arvicolinae - physiology Autoradiography Bacterial Proteins Corpus Striatum - physiology Corticotropin-releasing factor Corticotropin-Releasing Hormone - administration & dosage Corticotropin-Releasing Hormone - pharmacology Death Endocrinology & Metabolism Female Grieving Infusions, Intraventricular Luminescent Proteins Male Membrane Potentials - drug effects Membrane Potentials - physiology Microinjections Neurons - physiology Nucleus Accumbens - drug effects Nucleus Accumbens - physiology Oxytocin - administration & dosage Oxytocin - pharmacology Oxytocin - physiology Pair Bond Paraventricular Hypothalamic Nucleus - physiology Partner separation Passive stress-coping Peptide Fragments - administration & dosage Peptide Fragments - pharmacology Peptides, Cyclic - administration & dosage Peptides, Cyclic - pharmacology Psychiatry Radioimmunoassay Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors Receptors, Corticotropin-Releasing Hormone - metabolism Receptors, Corticotropin-Releasing Hormone - physiology Receptors, Oxytocin - antagonists & inhibitors Receptors, Oxytocin - metabolism RNA, Small Interfering - administration & dosage RNA, Small Interfering - pharmacology Social loss Stresscopin Urocortins - administration & dosage Urocortins - pharmacology Vasotocin - administration & dosage Vasotocin - analogs & derivatives Vasotocin - pharmacology
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Zusammenfassung:	Highlights • Male prairie voles show high passive stress-coping after loss of female partner. • This is mediated via activation of CRFR2 in nucleus accumbens shell. • Chronic activation of CRFR2 is capable of impairing the oxytocin system. • The oxytocin system gets compromised at multiple levels. • Suppression of oxytocin signaling is likely to encourage reunion with the partner.
ISSN:	0306-4530 1873-3360
DOI:	10.1016/j.psyneuen.2015.11.011