Molecular Mechanism Responsible for Fibronectin-controlled Alterations in Matrix Stiffness in Advanced Chronic Liver Fibrogenesis

Fibrosis is characterized by extracellular matrix (ECM) remodeling and stiffening. However, the functional contribution of tissue stiffening to noncancer pathogenesis remains largely unknown. Fibronectin (Fn) is an ECM glycoprotein substantially expressed during tissue repair. Here we show in advanc...

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Veröffentlicht in:The Journal of biological chemistry 2016-01, Vol.291 (1), p.72-88
Hauptverfasser: Iwasaki, Ayumi, Sakai, Keiko, Moriya, Kei, Sasaki, Takako, Keene, Douglas R., Akhtar, Riaz, Miyazono, Takayoshi, Yasumura, Satoshi, Watanabe, Masatoshi, Morishita, Shin, Sakai, Takao
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Sprache:eng
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