Antagonist of the neurokinin-1 receptor curbs neuroinflammation in ex vivo and in vitro models of Lyme neuroborreliosis

Lyme neuroborreliosis (LNB) can affect both the peripheral (PNS) and the central nervous systems (CNS); it is caused by the spirochete Borrelia burgdorferi. The neuropeptide substance P (SP) is an important mediator of both neuroinflammation and blood-brain barrier dysfunction, through its NK1 recep...

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Veröffentlicht in:	Journal of neuroinflammation 2015-12, Vol.12 (244), p.243-243, Article 243
Hauptverfasser:	Martinez, Alejandra N, Ramesh, Geeta, Jacobs, Mary B, Philipp, Mario T
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Apoptosis Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology Borrelia burgdorferi - physiology Brain - drug effects Brain - metabolism Brain - pathology Care and treatment Cells, Cultured Complications and side effects Ganglia, Spinal - drug effects Ganglia, Spinal - metabolism Ganglia, Spinal - pathology Inflammation Inflammation Mediators - antagonists & inhibitors Inflammation Mediators - metabolism Lyme disease Lyme Neuroborreliosis - drug therapy Lyme Neuroborreliosis - metabolism Lyme Neuroborreliosis - pathology Macaca mulatta Neuroglia - drug effects Neuroglia - metabolism Neuroglia - pathology Neurons - drug effects Neurons - metabolism Neurons - pathology Organ Culture Techniques Quinuclidines - pharmacology Quinuclidines - therapeutic use Receptors, Neurokinin-1 - metabolism Risk factors
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