siRNA screen identifies QPCT as a druggable target for Huntington's disease

An siRNA screen for genes that suppress mutant huntingtin toxicity in both mammalian cells and Drosophila identifies glutaminyl cyclase (QPCT). Newly generated small-molecule inhibitors further identify QPCT as a druggable target for Huntington′s disease. Huntington's disease (HD) is a currentl...

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Veröffentlicht in:	Nature chemical biology 2015-05, Vol.11 (5), p.347-354
Hauptverfasser:	Jimenez-Sanchez, Maria, Lam, Wun, Hannus, Michael, Sönnichsen, Birte, Imarisio, Sara, Fleming, Angeleen, Tarditi, Alessia, Menzies, Fiona, Ed Dami, Teresa, Xu, Catherine, Gonzalez-Couto, Eduardo, Lazzeroni, Giulia, Heitz, Freddy, Diamanti, Daniela, Massai, Luisa, Satagopam, Venkata P, Marconi, Guido, Caramelli, Chiara, Nencini, Arianna, Andreini, Matteo, Sardone, Gian Luca, Caradonna, Nicola P, Porcari, Valentina, Scali, Carla, Schneider, Reinhard, Pollio, Giuseppe, O'Kane, Cahir J, Caricasole, Andrea, Rubinsztein, David C
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/106 13/109 13/89 631/154/555 631/378 631/92/96 64 64/116 64/24 alpha-Crystallin B Chain - metabolism Aminoacyltransferases - antagonists & inhibitors Aminoacyltransferases - drug effects Aminoacyltransferases - genetics Animals Biochemical Engineering Biochemistry Bioorganic Chemistry Cell Biology Cells, Cultured Chemistry Chemistry/Food Science Computational Biology Danio rerio Drosophila Drug Evaluation, Preclinical Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Green Fluorescent Proteins - metabolism Humans Huntingtin Protein Huntington Disease - drug therapy Huntington Disease - genetics Mice Mice, Inbred C57BL Mutation - genetics Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons - drug effects Neurons - metabolism RNA, Small Interfering Zebrafish
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