Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate

Glutamine addiction in c-MYC-overexpressing breast cancer is targeted by the aminotransferase inhibitor, aminooxyacetate (AOA). However, the mechanism of ensuing cell death remains unresolved. A correlation between glutamine dependence for growth and c-MYC expression was studied in breast cancer cel...

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Veröffentlicht in:	Clinical cancer research 2015-07, Vol.21 (14), p.3263-3273
Hauptverfasser:	Korangath, Preethi, Teo, Wei Wen, Sadik, Helen, Han, Liangfeng, Mori, Noriko, Huijts, Charlotte M, Wildes, Flonne, Bharti, Santosh, Zhang, Zhe, Santa-Maria, Cesar A, Tsai, Hualing, Dang, Chi V, Stearns, Vered, Bhujwalla, Zaver M, Sukumar, Saraswati
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminooxyacetic Acid - pharmacology Animals Antineoplastic Agents - pharmacology Breast Neoplasms - metabolism Cell Line, Tumor Enzyme Inhibitors - pharmacology Female Glutamine - metabolism Humans Magnetic Resonance Spectroscopy Mice Mice, Transgenic Xenograft Model Antitumor Assays
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