Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer

Identifying druggable targets in the Wnt-signaling pathway can optimize colorectal cancer treatment. Recent studies have identified a member of the RNA helicase family DDX3 (DDX3X) as a multilevel activator of Wnt signaling in cells without activating mutations in the Wnt-signaling pathway. In this...

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Veröffentlicht in:	Oncotarget 2015-09, Vol.6 (29), p.28312-28326
Hauptverfasser:	Heerma van Voss, Marise R, Vesuna, Farhad, Trumpi, Kari, Brilliant, Justin, Berlinicke, Cynthia, de Leng, Wendy, Kranenburg, Onno, Offerhaus, G Johan, Bürger, Horst, van der Wall, Elsken, van Diest, Paul J, Raman, Venu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Azepines - pharmacology Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism beta Catenin - genetics beta Catenin - metabolism Cell Line, Tumor Cell Survival - drug effects Cell Survival - genetics Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism DEAD-box RNA Helicases - antagonists & inhibitors DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - metabolism Dose-Response Relationship, Drug Female Gene Expression Regulation, Neoplastic HCT116 Cells HT29 Cells Humans Imidazoles - pharmacology Immunoblotting Immunohistochemistry Male Middle Aged Molecular Targeted Therapy - methods Mutation Research Paper Reverse Transcriptase Polymerase Chain Reaction RNA Interference Transcription Factor 4 Transcription Factors - genetics Transcription Factors - metabolism Wnt Signaling Pathway - drug effects Wnt Signaling Pathway - genetics
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