A compendium of DIS3 mutations and associated transcriptional signatures in plasma cell dyscrasias

DIS3 is a catalytic subunit of the human exosome complex, containing exonucleolytic (RNB) and endonucleolytic (PIN) domains, recently found mutated in multiple myeloma (MM), a clinically and genetically heterogeneous form of plasma cell (PC) dyscrasia. We analyzed by next-generation sequencing (NGS)...

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Veröffentlicht in:	Oncotarget 2015-09, Vol.6 (28), p.26129-26141
Hauptverfasser:	Lionetti, Marta, Barbieri, Marzia, Todoerti, Katia, Agnelli, Luca, Fabris, Sonia, Tonon, Giovanni, Segalla, Simona, Cifola, Ingrid, Pinatel, Eva, Tassone, Pierfrancesco, Musto, Pellegrino, Baldini, Luca, Neri, Antonino
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Amino Acid Sequence Cell Line, Tumor Disease Progression Exosome Multienzyme Ribonuclease Complex - genetics Female Gene Expression Profiling Gene Ontology High-Throughput Nucleotide Sequencing - methods Humans Male Middle Aged Molecular Sequence Data Multiple Myeloma - genetics Multiple Myeloma - pathology Mutation Paraproteinemias - genetics Paraproteinemias - pathology Prognosis Research Paper Sequence Homology, Amino Acid
Online-Zugang:	Volltext
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