ZIP4 silencing improves bone loss in pancreatic cancer

Metabolic bone disorders are associated with several types of human cancers. Pancreatic cancer patients usually suffer from severe nutrition deficiency, muscle wasting, and loss of bone mass. We have previously found that silencing of a zinc transporter ZIP4 prolongs the survival and reduces the sev...

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Veröffentlicht in:	Oncotarget 2015-09, Vol.6 (28), p.26041-26051
Hauptverfasser:	Zhang, Qiang, Sun, Xiaotian, Yang, Jingxuan, Ding, Hao, LeBrun, Drake, Ding, Kai, Houchen, Courtney W, Postier, Russell G, Ambrose, Catherine G, Li, Zhaoshen, Bi, Xiaohong, Li, Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Bone Density Bone Resorption - genetics Bone Resorption - metabolism Bone Resorption - therapy Cation Transport Proteins - genetics Cation Transport Proteins - metabolism Cell Line Cell Line, Tumor Femur - metabolism Femur - pathology Femur - physiopathology Humans Male Mechanical Phenomena Mice, Nude Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - therapy RANK Ligand - metabolism Receptor Activator of Nuclear Factor-kappa B - metabolism Research Paper RNA Interference RNAi Therapeutics - methods X-Ray Microtomography Xenograft Model Antitumor Assays
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