A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models

Many cancer cells rely on aerobic glycolysis for energy production and targeting of this pathway is a potential strategy to inhibit cancer cell growth. In this study, inhibition of five glycolysis pathway molecules (GLUT1, HKII, PFKFB3, PDHK1 and LDH) using 9 inhibitors (Phloretin, Quercetin, STF31,...

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Veröffentlicht in:	Oncotarget 2015-09, Vol.6 (28), p.25677-25695
Hauptverfasser:	Xintaropoulou, Chrysi, Ward, Carol, Wise, Alan, Marston, Hugh, Turnbull, Arran, Langdon, Simon P
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis - drug effects Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Hypoxia Cell Proliferation - drug effects Dose-Response Relationship, Drug Drug Synergism Female Glucose - metabolism Glycolysis - drug effects Humans Inhibitory Concentration 50 Lactic Acid - metabolism MCF-7 Cells Molecular Targeted Therapy Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Oxygen - metabolism Research Paper
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