Epigenetic engineering shows that a human centromere resists silencing mediated by H3K27me3/K9me3

Centromeres are characterized by the centromere-specific H3 variant CENP-A, which is embedded in chromatin with a pattern characteristic of active transcription that is required for centromere identity. It is unclear how centromeres remain transcriptionally active despite being flanked by repressive...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular biology of the cell 2016-01, Vol.27 (1), p.177-196
Hauptverfasser:	Martins, Nuno M C, Bergmann, Jan H, Shono, Nobuaki, Kimura, Hiroshi, Larionov, Vladimir, Masumoto, Hiroshi, Earnshaw, William C
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle Proteins - metabolism Cells, Cultured Centromere - genetics Centromere - metabolism Chromatin - metabolism Chromosomes, Artificial, Human Enhancer of Zeste Homolog 2 Protein Epigenesis, Genetic Epigenomics - methods HeLa Cells Heterochromatin - metabolism Histones - genetics Histones - metabolism Humans Kinetochores - metabolism Methyltransferases - genetics Polycomb Repressive Complex 2
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!