EphA2 Expression Is a Key Driver of Migration and Invasion and a Poor Prognostic Marker in Colorectal Cancer

EphA2, a member of the Eph receptor tyrosine kinases family, is an important regulator of tumor initiation, neovascularization, and metastasis in a wide range of epithelial and mesenchymal cancers; however, its role in colorectal cancer recurrence and progression is unclear. EphA2 expression was det...

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Veröffentlicht in:	Clinical cancer research 2016-01, Vol.22 (1), p.230-242
Hauptverfasser:	Dunne, Philip D, Dasgupta, Sonali, Blayney, Jaine K, McArt, Darragh G, Redmond, Keara L, Weir, Jessica-Anne, Bradley, Conor A, Sasazuki, Takehiko, Shirasawa, Senji, Wang, Tingting, Srivastava, Supriya, Ong, Chee Wee, Arthur, Ken, Salto-Tellez, Manuel, Wilson, Richard H, Johnston, Patrick G, Van Schaeybroeck, Sandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor Cell Line, Tumor Cell Movement - genetics Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Gene Expression Humans Kaplan-Meier Estimate Neoplasm Invasiveness Neoplasm Staging Prognosis Proportional Hazards Models Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - metabolism ral GTP-Binding Proteins - metabolism ral Guanine Nucleotide Exchange Factor - metabolism ras Proteins - metabolism Receptor, EphA2 - genetics Receptor, EphA2 - metabolism Reproducibility of Results Signal Transduction
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