Brucella abortus Invasion of Osteocytes Modulates Connexin 43 and Integrin Expression and Induces Osteoclastogenesis via Receptor Activator of NF-κB Ligand and Tumor Necrosis Factor Alpha Secretion

Osteoarticular brucellosis is the most common localization of human active disease. Osteocytes are the most abundant cells of bone. They secrete factors that regulate the differentiation of both osteoblasts and osteoclasts during bone remodeling. The aim of this study is to determine if Brucella abo...

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Veröffentlicht in:	Infection and immunity 2016-01, Vol.84 (1), p.11-20
Hauptverfasser:	Pesce Viglietti, Ayelén Ivana, Arriola Benitez, Paula Constanza, Gentilini, María Virginia, Velásquez, Lis Noelia, Fossati, Carlos Alberto, Giambartolomei, Guillermo Hernán, Delpino, María Victoria
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Brucella abortus Brucella abortus - pathogenicity Brucellosis - microbiology Brucellosis - pathology Cell Differentiation Cell Line Chemokine CXCL1 - metabolism Chemokine CXCL1 - secretion Connexin 43 - biosynthesis Host Response and Inflammation Integrins - biosynthesis Macrophages - microbiology Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 2 - secretion Mice Osteoclasts - cytology Osteocytes - metabolism Osteocytes - microbiology Osteoprotegerin - immunology RANK Ligand - metabolism RANK Ligand - secretion Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - secretion
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