Shiga Toxins Activate the NLRP3 Inflammasome Pathway To Promote Both Production of the Proinflammatory Cytokine Interleukin-1β and Apoptotic Cell Death

Shiga toxin (Stx)-mediated immune responses, including the production of the proinflammatory cytokines tumor necrosis-α (TNF-α) and interleukin-1β (IL-1β), may exacerbate vascular damage and accelerate lethality. However, the immune signaling pathway activated in response to Stx is not well understo...

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Veröffentlicht in:	Infection and immunity 2016-01, Vol.84 (1), p.172-186
Hauptverfasser:	Lee, Moo-Seung, Kwon, Haenaem, Lee, Eun-Young, Kim, Dong-Jae, Park, Jong-Hwan, Tesh, Vernon L, Oh, Tae-Kwang, Kim, Myung Hee
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium-Binding Proteins - genetics Calcium-Binding Proteins - immunology CARD Signaling Adaptor Proteins - genetics CARD Signaling Adaptor Proteins - immunology Carrier Proteins - genetics Carrier Proteins - immunology Caspase 1 - genetics Caspase 1 - immunology Caspase 3 - immunology Caspase 8 - immunology Cell Line, Tumor Cellular Microbiology: Pathogen-Host Cell Molecular Interactions Cytoskeletal Proteins - genetics Cytoskeletal Proteins - immunology DNA-Binding Proteins - genetics DNA-Binding Proteins - immunology Enzyme Activation - immunology Glycosphingolipids - biosynthesis Humans Inflammation - immunology Interleukin-1beta - biosynthesis Interleukin-1beta - immunology Interleukin-1beta - secretion NLR Family, Pyrin Domain-Containing 3 Protein Pyroptosis - immunology RNA Interference RNA, Small Interfering Shiga Toxins - immunology Shiga-Toxigenic Escherichia coli - metabolism Signal Transduction - immunology Trihexosylceramides - biosynthesis Tumor Necrosis Factor-alpha - immunology
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