Awareness, knowledge and views of off‐label prescribing in children: a systematic review
Aim The aim of this review was to provide an updated overview of awareness, knowledge and views of off‐label prescribing in children. Method A literature search using electronic databases including PubMed, Medline, Scopus, Science Direct, Springer Link, Proquest, Ebsco Host and Google Scholar was co...
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| Veröffentlicht in: | British journal of clinical pharmacology 2015-12, Vol.80 (6), p.1269-1280 |
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| container_title | British journal of clinical pharmacology |
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| creator | Balan, S. Hassali, M. A. Mak, V. S. L. |
| description | Aim
The aim of this review was to provide an updated overview of awareness, knowledge and views of off‐label prescribing in children.
Method
A literature search using electronic databases including PubMed, Medline, Scopus, Science Direct, Springer Link, Proquest, Ebsco Host and Google Scholar was conducted. Additional articles were identified by reviewing the bibliography of retrieved articles. The articles were searched with any of the following medical subject headings (MeSH) terms in the title: attitude, awareness, knowledge, experience, view, off‐label, pediatric, paediatric and children. The inclusion criteria were full text articles published in English between January 2004 and February 2015 and reported outcome related to awareness, knowledge and views regarding off‐label prescribing in children. Editorials, reviews, notes, conference proceedings, letters and studies reporting prevalence of off‐label prescribing were excluded. The articles were scrutinized using thematic analysis.
Results
Eleven studies conducted among doctors, community pharmacists, paediatric nurses, parents and children met the inclusion criteria. Nine themes were developed through document analysis which included main domains such as knowledge, awareness and views on off‐label drug use in children, choice of information sources, reasons and suggestions to reduce off‐label prescribing, concern regarding obtaining consent and participation in clinical trials.
Conclusion
The studies reviewed reported that the majority of doctors and community pharmacists were familiar with the term off‐label prescribing but knowledge among parents was low. Awareness on off‐label prescribing in children remains low among all study participants. There is a mismatch between views on off‐label prescribing in children of study participants and the finding of previous studies. |
| doi_str_mv | 10.1111/bcp.12750 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4693483</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1744664203</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4850-ebbd6fac0523b6a71a7107d7fdbbd5b43d40478c00225e7184414b8c4c717e823</originalsourceid><addsrcrecordid>eNp1kctOGzEUhq0KBIGy6AsgL1uJCb572kUlGnGTkGDRbrqxbM-Z4NaZSe2EKDsegWfkSXBIQHSBdSQvzne-Y_lH6BMlQ1rOsfPTIWVakg9oQLmSFaNMbqEB4URVkkm6i_Zy_kMI5VTJHbTLFKeiFnSAfp8sbIIOcj7Cf7t-EaEZA7Zdg-8CLDLu21Lt4_1DtA4inibIPgUXujEOHfa3ITZl_Bu2OC_zDCZ2FjxOsBr-iLZbGzMcbO599Ovs9Ofoorq6Pr8cnVxVXtSSVOBco1rriWTcKatpKaIb3TalIZ3gjSBC154QxiRoWgtBhau98JpqqBnfR9_X3uncTaDx0M2SjWaawsSmpeltMP93unBrxv2dEeorFzUvgs8bQer_zSHPzCRkDzHaDvp5NlQLoZRgZIV-WaM-9TknaF_XUGJWWZiShXnOorCHb9_1Sr58fgGO18AiRFi-bzI_Rjdr5RNG0ZVX</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1744664203</pqid></control><display><type>article</type><title>Awareness, knowledge and views of off‐label prescribing in children: a systematic review</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Balan, S. ; Hassali, M. A. ; Mak, V. S. L.</creator><creatorcontrib>Balan, S. ; Hassali, M. A. ; Mak, V. S. L.</creatorcontrib><description>Aim
The aim of this review was to provide an updated overview of awareness, knowledge and views of off‐label prescribing in children.
Method
A literature search using electronic databases including PubMed, Medline, Scopus, Science Direct, Springer Link, Proquest, Ebsco Host and Google Scholar was conducted. Additional articles were identified by reviewing the bibliography of retrieved articles. The articles were searched with any of the following medical subject headings (MeSH) terms in the title: attitude, awareness, knowledge, experience, view, off‐label, pediatric, paediatric and children. The inclusion criteria were full text articles published in English between January 2004 and February 2015 and reported outcome related to awareness, knowledge and views regarding off‐label prescribing in children. Editorials, reviews, notes, conference proceedings, letters and studies reporting prevalence of off‐label prescribing were excluded. The articles were scrutinized using thematic analysis.
Results
Eleven studies conducted among doctors, community pharmacists, paediatric nurses, parents and children met the inclusion criteria. Nine themes were developed through document analysis which included main domains such as knowledge, awareness and views on off‐label drug use in children, choice of information sources, reasons and suggestions to reduce off‐label prescribing, concern regarding obtaining consent and participation in clinical trials.
Conclusion
The studies reviewed reported that the majority of doctors and community pharmacists were familiar with the term off‐label prescribing but knowledge among parents was low. Awareness on off‐label prescribing in children remains low among all study participants. There is a mismatch between views on off‐label prescribing in children of study participants and the finding of previous studies.</description><identifier>ISSN: 0306-5251</identifier><identifier>EISSN: 1365-2125</identifier><identifier>DOI: 10.1111/bcp.12750</identifier><identifier>PMID: 26314841</identifier><language>eng</language><publisher>England: John Wiley and Sons Inc</publisher><subject>attitude ; Awareness ; Child ; children ; Clinical Trials as Topic ; Communication ; Humans ; Informed Consent ; Knowledge ; Off-Label Use ; off‐label ; paediatric ; Parents ; Pharmacists ; Physicians ; Systematic Review ; Systematic Reviews ; views</subject><ispartof>British journal of clinical pharmacology, 2015-12, Vol.80 (6), p.1269-1280</ispartof><rights>2015 The British Pharmacological Society</rights><rights>2015 The British Pharmacological Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4850-ebbd6fac0523b6a71a7107d7fdbbd5b43d40478c00225e7184414b8c4c717e823</citedby><cites>FETCH-LOGICAL-c4850-ebbd6fac0523b6a71a7107d7fdbbd5b43d40478c00225e7184414b8c4c717e823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbcp.12750$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbcp.12750$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26314841$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Balan, S.</creatorcontrib><creatorcontrib>Hassali, M. A.</creatorcontrib><creatorcontrib>Mak, V. S. L.</creatorcontrib><title>Awareness, knowledge and views of off‐label prescribing in children: a systematic review</title><title>British journal of clinical pharmacology</title><addtitle>Br J Clin Pharmacol</addtitle><description>Aim
The aim of this review was to provide an updated overview of awareness, knowledge and views of off‐label prescribing in children.
Method
A literature search using electronic databases including PubMed, Medline, Scopus, Science Direct, Springer Link, Proquest, Ebsco Host and Google Scholar was conducted. Additional articles were identified by reviewing the bibliography of retrieved articles. The articles were searched with any of the following medical subject headings (MeSH) terms in the title: attitude, awareness, knowledge, experience, view, off‐label, pediatric, paediatric and children. The inclusion criteria were full text articles published in English between January 2004 and February 2015 and reported outcome related to awareness, knowledge and views regarding off‐label prescribing in children. Editorials, reviews, notes, conference proceedings, letters and studies reporting prevalence of off‐label prescribing were excluded. The articles were scrutinized using thematic analysis.
Results
Eleven studies conducted among doctors, community pharmacists, paediatric nurses, parents and children met the inclusion criteria. Nine themes were developed through document analysis which included main domains such as knowledge, awareness and views on off‐label drug use in children, choice of information sources, reasons and suggestions to reduce off‐label prescribing, concern regarding obtaining consent and participation in clinical trials.
Conclusion
The studies reviewed reported that the majority of doctors and community pharmacists were familiar with the term off‐label prescribing but knowledge among parents was low. Awareness on off‐label prescribing in children remains low among all study participants. There is a mismatch between views on off‐label prescribing in children of study participants and the finding of previous studies.</description><subject>attitude</subject><subject>Awareness</subject><subject>Child</subject><subject>children</subject><subject>Clinical Trials as Topic</subject><subject>Communication</subject><subject>Humans</subject><subject>Informed Consent</subject><subject>Knowledge</subject><subject>Off-Label Use</subject><subject>off‐label</subject><subject>paediatric</subject><subject>Parents</subject><subject>Pharmacists</subject><subject>Physicians</subject><subject>Systematic Review</subject><subject>Systematic Reviews</subject><subject>views</subject><issn>0306-5251</issn><issn>1365-2125</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctOGzEUhq0KBIGy6AsgL1uJCb572kUlGnGTkGDRbrqxbM-Z4NaZSe2EKDsegWfkSXBIQHSBdSQvzne-Y_lH6BMlQ1rOsfPTIWVakg9oQLmSFaNMbqEB4URVkkm6i_Zy_kMI5VTJHbTLFKeiFnSAfp8sbIIOcj7Cf7t-EaEZA7Zdg-8CLDLu21Lt4_1DtA4inibIPgUXujEOHfa3ITZl_Bu2OC_zDCZ2FjxOsBr-iLZbGzMcbO599Ovs9Ofoorq6Pr8cnVxVXtSSVOBco1rriWTcKatpKaIb3TalIZ3gjSBC154QxiRoWgtBhau98JpqqBnfR9_X3uncTaDx0M2SjWaawsSmpeltMP93unBrxv2dEeorFzUvgs8bQer_zSHPzCRkDzHaDvp5NlQLoZRgZIV-WaM-9TknaF_XUGJWWZiShXnOorCHb9_1Sr58fgGO18AiRFi-bzI_Rjdr5RNG0ZVX</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>Balan, S.</creator><creator>Hassali, M. A.</creator><creator>Mak, V. S. L.</creator><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201512</creationdate><title>Awareness, knowledge and views of off‐label prescribing in children: a systematic review</title><author>Balan, S. ; Hassali, M. A. ; Mak, V. S. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4850-ebbd6fac0523b6a71a7107d7fdbbd5b43d40478c00225e7184414b8c4c717e823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>attitude</topic><topic>Awareness</topic><topic>Child</topic><topic>children</topic><topic>Clinical Trials as Topic</topic><topic>Communication</topic><topic>Humans</topic><topic>Informed Consent</topic><topic>Knowledge</topic><topic>Off-Label Use</topic><topic>off‐label</topic><topic>paediatric</topic><topic>Parents</topic><topic>Pharmacists</topic><topic>Physicians</topic><topic>Systematic Review</topic><topic>Systematic Reviews</topic><topic>views</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Balan, S.</creatorcontrib><creatorcontrib>Hassali, M. A.</creatorcontrib><creatorcontrib>Mak, V. S. L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Balan, S.</au><au>Hassali, M. A.</au><au>Mak, V. S. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Awareness, knowledge and views of off‐label prescribing in children: a systematic review</atitle><jtitle>British journal of clinical pharmacology</jtitle><addtitle>Br J Clin Pharmacol</addtitle><date>2015-12</date><risdate>2015</risdate><volume>80</volume><issue>6</issue><spage>1269</spage><epage>1280</epage><pages>1269-1280</pages><issn>0306-5251</issn><eissn>1365-2125</eissn><abstract>Aim
The aim of this review was to provide an updated overview of awareness, knowledge and views of off‐label prescribing in children.
Method
A literature search using electronic databases including PubMed, Medline, Scopus, Science Direct, Springer Link, Proquest, Ebsco Host and Google Scholar was conducted. Additional articles were identified by reviewing the bibliography of retrieved articles. The articles were searched with any of the following medical subject headings (MeSH) terms in the title: attitude, awareness, knowledge, experience, view, off‐label, pediatric, paediatric and children. The inclusion criteria were full text articles published in English between January 2004 and February 2015 and reported outcome related to awareness, knowledge and views regarding off‐label prescribing in children. Editorials, reviews, notes, conference proceedings, letters and studies reporting prevalence of off‐label prescribing were excluded. The articles were scrutinized using thematic analysis.
Results
Eleven studies conducted among doctors, community pharmacists, paediatric nurses, parents and children met the inclusion criteria. Nine themes were developed through document analysis which included main domains such as knowledge, awareness and views on off‐label drug use in children, choice of information sources, reasons and suggestions to reduce off‐label prescribing, concern regarding obtaining consent and participation in clinical trials.
Conclusion
The studies reviewed reported that the majority of doctors and community pharmacists were familiar with the term off‐label prescribing but knowledge among parents was low. Awareness on off‐label prescribing in children remains low among all study participants. There is a mismatch between views on off‐label prescribing in children of study participants and the finding of previous studies.</abstract><cop>England</cop><pub>John Wiley and Sons Inc</pub><pmid>26314841</pmid><doi>10.1111/bcp.12750</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | attitude Awareness Child children Clinical Trials as Topic Communication Humans Informed Consent Knowledge Off-Label Use off‐label paediatric Parents Pharmacists Physicians Systematic Review Systematic Reviews views |
| title | Awareness, knowledge and views of off‐label prescribing in children: a systematic review |
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