Sequential exposure to fibroblast growth factors (FGF) 2, 9 and 18 enhances hMSC chondrogenic differentiation

Summary Objective To test the effects of sequential exposure to FGF2, 9 and 18 on human Mesenchymal Stem Cells (hMSC) differentiation during in vitro chondrogenesis. Design Control and FGF2-expanded hMSC were cultured in aggregates in the presence of rhFGF9, rhFGF18 or rhFGFR3-specific signaling FGF...

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Veröffentlicht in:	Osteoarthritis and cartilage 2015-03, Vol.23 (3), p.443-453
Hauptverfasser:	Correa, D, Somoza, R.A, Lin, P, Greenberg, S, Rom, E, Duesler, L, Welter, J.F, Yayon, A, Caplan, A.I
Format:	Artikel
Sprache:	eng
Schlagworte:	Cartilage repair Cell Differentiation - drug effects Cells, Cultured Chondrocytes - drug effects Chondrocytes - metabolism Chondrogenesis Chondrogenesis - drug effects FGFR Fibroblast growth factor (FGF) Fibroblast Growth Factor 2 - pharmacology Fibroblast Growth Factor 9 - pharmacology Fibroblast Growth Factors - pharmacology Humans Hypertrophy In Vitro Techniques Mesenchymal stem cells Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - metabolism Receptor, Fibroblast Growth Factor, Type 1 - drug effects Receptor, Fibroblast Growth Factor, Type 1 - genetics Receptor, Fibroblast Growth Factor, Type 1 - metabolism Receptor, Fibroblast Growth Factor, Type 3 - drug effects Receptor, Fibroblast Growth Factor, Type 3 - genetics Receptor, Fibroblast Growth Factor, Type 3 - metabolism Rheumatology
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