A revised model for estimating g-ratio from MRI
A key measure of white matter health is the g-ratio, which is defined as the ratio between the inner axon radius and the outer, myelinated, axon radius. Recent methods have been proposed to measure the g-ratio non-invasively using the relationship between two magnetic resonance imaging (MRI) measure...
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| Veröffentlicht in: | NeuroImage (Orlando, Fla.) Fla.), 2016-01, Vol.125, p.1155-1158 |
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| creator | West, Kathryn L. Kelm, Nathaniel D. Carson, Robert P. Does, Mark D. |
| description | A key measure of white matter health is the g-ratio, which is defined as the ratio between the inner axon radius and the outer, myelinated, axon radius. Recent methods have been proposed to measure the g-ratio non-invasively using the relationship between two magnetic resonance imaging (MRI) measures. While this relationship is intuitive, it predicates on the simplifying assumption that g-ratio is constant across axons. Here, we extend the model to account for a distribution of g-ratio values within an imaging voxel, and evaluate this model with quantitative histology from normal and hypomyelinated mouse brains.
•Revised model for MRI measure of g-ratio, accounting for distribution of g values•gMRI reports on axon-area-weighted measures of g-ratio•Validation with quantitative histology from control and hypomyelinated mice |
| doi_str_mv | 10.1016/j.neuroimage.2015.08.017 |
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•Revised model for MRI measure of g-ratio, accounting for distribution of g values•gMRI reports on axon-area-weighted measures of g-ratio•Validation with quantitative histology from control and hypomyelinated mice</description><subject>Animals</subject><subject>Corpus Callosum - pathology</subject><subject>Disease Models, Animal</subject><subject>Estimates</subject><subject>g-ratio</subject><subject>Histology</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Methods</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Microscopy</subject><subject>Myelin</subject><subject>Myelin Sheath - pathology</subject><subject>Nerve Fibers, Myelinated - pathology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>White Matter - pathology</subject><issn>1053-8119</issn><issn>1095-9572</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkUtv1TAQhS0EoqXwF1AkNmyS-hl7NkilglKpCAnB2nKcycVXSVzs5Er8e5zeUh4bVh7JZ87MmY-QitGGUdae75sZ1xTD5HbYcMpUQ01DmX5EThkFVYPS_PFWK1EbxuCEPMt5TykFJs1TcsJbDqBBnJLziyrhIWTsqyn2OFZDTBXmpVgvYd5VuzqVIlZDilP18fP1c_JkcGPGF_fvGfn6_t2Xyw_1zaer68uLm9orqpfae1BOInYCBua1k53opNbScZQ9tgJ6LQFpR53m4CUfpEGEtvNy6A0qIc7Im6Pv7dpN2Hucl-RGe5vKYumHjS7Yv3_m8M3u4sHKFpgwshi8vjdI8ftaEtkpZI_j6GaMa7ZMKwbADd9mvfpHuo9rmku8TSWUAnVnaI4qn2LOCYeHZRi1GxW7t7-p2I2KpcYWKqX15Z9hHhp_YSiCt0cBlpMeAiabfcDZYx8S-sX2Mfx_yk8kA6Mv</recordid><startdate>20160115</startdate><enddate>20160115</enddate><creator>West, Kathryn L.</creator><creator>Kelm, Nathaniel D.</creator><creator>Carson, Robert P.</creator><creator>Does, Mark D.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160115</creationdate><title>A revised model for estimating g-ratio from MRI</title><author>West, Kathryn L. ; 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| subjects | Animals Corpus Callosum - pathology Disease Models, Animal Estimates g-ratio Histology Image Processing, Computer-Assisted - methods Magnetic resonance imaging Magnetic Resonance Imaging - methods Methods Mice Mice, Knockout Microscopy Myelin Myelin Sheath - pathology Nerve Fibers, Myelinated - pathology NMR Nuclear magnetic resonance White Matter - pathology |
| title | A revised model for estimating g-ratio from MRI |
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