Genetic and Epigenetic Variation, but Not Diet, Shape the Sperm Methylome

Paternal diet can impact metabolic phenotypes in offspring, but mechanisms underlying such intergenerational information transfer remain obscure. Here, we interrogate cytosine methylation patterns in sperm obtained from mice consuming one of three diets, generating whole genome methylation maps for...

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Veröffentlicht in:	Developmental cell 2015-12, Vol.35 (6), p.750-758
Hauptverfasser:	Shea, Jeremy M., Serra, Ryan W., Carone, Benjamin R., Shulha, Hennady P., Kucukural, Alper, Ziller, Michael J., Vallaster, Markus P., Gu, Hongcang, Tapper, Andrew R., Gardner, Paul D., Meissner, Alexander, Garber, Manuel, Rando, Oliver J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diet DNA Methylation - genetics DNA, Ribosomal - genetics Epigenesis, Genetic - genetics Epigenomics Genetic Variation Genome - genetics Male Mice Spermatozoa - metabolism
Online-Zugang:	Volltext
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