Innate Immunity and Inflammation Post-Stroke: An α7-Nicotinic Agonist Perspective
Stroke is one of the leading causes of death and long-term disability, with limited treatment options available. Inflammation contributes to damage tissue in the central nervous system across a broad range of neuropathologies, including Alzheimer's disease, pain, Schizophrenia, and stroke. Whil...
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| Veröffentlicht in: | International journal of molecular sciences 2015-12, Vol.16 (12), p.29029-29046 |
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| container_title | International journal of molecular sciences |
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| creator | Neumann, Silke Shields, Nicholas J Balle, Thomas Chebib, Mary Clarkson, Andrew N |
| description | Stroke is one of the leading causes of death and long-term disability, with limited treatment options available. Inflammation contributes to damage tissue in the central nervous system across a broad range of neuropathologies, including Alzheimer's disease, pain, Schizophrenia, and stroke. While the immune system plays an important role in contributing to brain damage produced by ischemia, the damaged brain, in turn, can exert a powerful immune-suppressive effect that promotes infections and threatens the survival of stroke patients. Recently the cholinergic anti-inflammatory pathway, in particular its modulation using α7-nicotinic acetylcholine receptor (α7-nAChR) ligands, has shown potential as a strategy to dampen the inflammatory response and facilitate functional recovery in stroke patients. Here we discuss the current literature on stroke-induced inflammation and the effects of α7-nAChR modulators on innate immune cells. |
| doi_str_mv | 10.3390/ijms161226141 |
| format | Article |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | alpha7 Nicotinic Acetylcholine Receptor - agonists alpha7 Nicotinic Acetylcholine Receptor - immunology Animals Humans Immunity, Innate - drug effects Inflammation - drug therapy Inflammation - etiology Inflammation - immunology Inflammation - pathology Myeloid Cells - drug effects Myeloid Cells - immunology Myeloid Cells - pathology Review Stroke - complications Stroke - drug therapy Stroke - immunology Stroke - pathology |
| title | Innate Immunity and Inflammation Post-Stroke: An α7-Nicotinic Agonist Perspective |
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