Regulation of Cholesterol Homeostasis by Hedgehog Signaling in Osteoarthritic Cartilage

Objective With no effective therapies to attenuate cartilage degeneration in osteoarthritis (OA), the result is pain and disability. Activation of hedgehog (HH) signaling causes changes related to the progression of OA, with higher levels of Gli‐mediated transcriptional activation associated with in...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2016-01, Vol.68 (1), p.127-137
Hauptverfasser:	Ali, Shabana Amanda, Al‐Jazrawe, Mushriq, Ma, Henry, Whetstone, Heather, Poon, Raymond, Farr, Sarah, Naples, Mark, Adeli, Khosrow, Alman, Benjamin A.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - metabolism ADAMTS5 Protein Animals Anticholesteremic Agents - pharmacology Blotting, Western Cartilage, Articular - drug effects Cartilage, Articular - metabolism Cholesterol Cholesterol - metabolism Chondrocytes - drug effects Chondrocytes - metabolism Collagen Type II - genetics Gene expression Gene Expression Regulation Hedgehog Proteins - antagonists & inhibitors Hedgehog Proteins - metabolism Homeostasis Homeostasis - genetics Humans In Vitro Techniques Kruppel-Like Transcription Factors - genetics Lovastatin - pharmacology Matrix Metalloproteinase 13 - metabolism Membrane Proteins - genetics Mice Mice, Knockout Osteoarthritis Osteoarthritis - genetics Osteoarthritis - metabolism Radiography Severity of Illness Index Signal Transduction Sterols - metabolism Stifle - diagnostic imaging Stifle - metabolism Stifle - pathology Zinc Finger Protein Gli2
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