Potential anti-cancer effect of N-hydroxy-7-(2-naphthylthio) heptanomide (HNHA), a novel histone deacetylase inhibitor, for the treatment of thyroid cancer

Thyroid cancer has been indicated to have a higher global proportion of DNA methylation and a decreased level of histone acetylation. Previous studies showed that histone gene reviser and epigenetic changes role significant parts in papillary and anaplastic thyroid cancer tumorigenesis. The goal of...

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Veröffentlicht in:	BMC cancer 2015-12, Vol.15 (1), p.1003-1003, Article 1003
Hauptverfasser:	Kim, Seok-Mo, Park, Ki-Cheong, Jeon, Jeong-Yong, Kim, Bup-Woo, Kim, Hyeung-Kyoo, Chang, Ho-Jin, Choi, Seung-Hoon, Park, Cheong-Soo, Chang, Hang-Seok
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Autophagy Calcium - metabolism Cancer therapies Caspases - metabolism Cell death Cell Line, Tumor Diabetes DNA methylation Endoplasmic Reticulum - metabolism Epigenetics Histone Deacetylase Inhibitors - pharmacology Humans Hydroxamic Acids - pharmacology Immunohistochemistry Kidney cancer Kinases Multiple myeloma Naphthalenes - pharmacology Proto-Oncogene Proteins c-bcl-2 - metabolism Thyroid cancer Thyroid Neoplasms - drug therapy Thyroid Neoplasms - metabolism
Online-Zugang:	Volltext
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