Maternal Low Quality Protein Diet Alters Plasma Amino Acid Concentrations of Weaning Rats
Several studies have indicated the influence of a maternal low protein diet on the fetus. However, the effect of a maternal low quality protein diet on fetal growth and development is largely unknown. Wistar rats (11 weeks old) were mated and maintained on either a chow diet with 20% casein (n = 6)...
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| Veröffentlicht in: | Nutrients 2015-12, Vol.7 (12), p.9847-9859 |
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| creator | Kabasakal Cetin, Arzu Dasgin, Halil Gülec, Atila Onbasilar, İlyas Akyol, Asli |
| description | Several studies have indicated the influence of a maternal low protein diet on the fetus. However, the effect of a maternal low quality protein diet on fetal growth and development is largely unknown. Wistar rats (11 weeks old) were mated and maintained on either a chow diet with 20% casein (n = 6) as the control group (C), or a low quality protein diet with 20% wheat gluten (n = 7) as the experimental group (WG) through gestation and lactation. Maternal body weights were similar in both groups throughout the study. Birth weights were not influenced by maternal diet and offspring body weights during lactation were similar between the groups. Offspring's plasma amino acid profiles showed that plasma methionine, glutamine and lysine were significantly lower and aspartic acid, ornithine and glycine-proline were significantly higher in the WG. Plant based protein comprises an important part of protein intake in developing countries. It is well-known that these diets can be inadequate in terms of essential amino acids. The current study shows differential effects of a maternal low quality protein diet on the offspring's plasma amino acids. Future studies will examine further aspects of the influence of maternal low quality protein diets on fetal growth and development. |
| doi_str_mv | 10.3390/nu7125508 |
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However, the effect of a maternal low quality protein diet on fetal growth and development is largely unknown. Wistar rats (11 weeks old) were mated and maintained on either a chow diet with 20% casein (n = 6) as the control group (C), or a low quality protein diet with 20% wheat gluten (n = 7) as the experimental group (WG) through gestation and lactation. Maternal body weights were similar in both groups throughout the study. Birth weights were not influenced by maternal diet and offspring body weights during lactation were similar between the groups. Offspring's plasma amino acid profiles showed that plasma methionine, glutamine and lysine were significantly lower and aspartic acid, ornithine and glycine-proline were significantly higher in the WG. Plant based protein comprises an important part of protein intake in developing countries. It is well-known that these diets can be inadequate in terms of essential amino acids. The current study shows differential effects of a maternal low quality protein diet on the offspring's plasma amino acids. Future studies will examine further aspects of the influence of maternal low quality protein diets on fetal growth and development.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu7125508</identifier><identifier>PMID: 26633475</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>amino acid composition ; Amino acids ; Amino Acids - blood ; Animal Nutritional Physiological Phenomena ; Animals ; Aspartic acid ; birth weight ; Breastfeeding & lactation ; Casein ; Developing countries ; Diet ; Dietary Proteins - administration & dosage ; Dietary Proteins - analysis ; essential amino acids ; Female ; fetal development ; fetus ; Fetuses ; Gestation ; Glutamine ; Gluten ; Glycine ; growth and development ; laboratory animals ; Lactation ; LDCs ; Low protein diet ; Lysine ; maternal nutrition ; Maternal Nutritional Physiological Phenomena ; Methionine ; Nutrient deficiency ; Offspring ; Ornithine ; Plant-based foods ; Plasma ; Pregnancy ; progeny ; Proline ; protein intake ; Proteins ; Quality ; Rats ; Rats, Wistar ; Supply & demand ; Weaning ; Wheat ; wheat gluten</subject><ispartof>Nutrients, 2015-12, Vol.7 (12), p.9847-9859</ispartof><rights>2015. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 by the authors; licensee MDPI, Basel, Switzerland. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-52937ca424f3ee7cce8164e1490f2e094ed924d076c4b4253df888ce849fb5fe3</citedby><cites>FETCH-LOGICAL-c432t-52937ca424f3ee7cce8164e1490f2e094ed924d076c4b4253df888ce849fb5fe3</cites><orcidid>0000-0001-6301-6358</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690060/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690060/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26633475$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kabasakal Cetin, Arzu</creatorcontrib><creatorcontrib>Dasgin, Halil</creatorcontrib><creatorcontrib>Gülec, Atila</creatorcontrib><creatorcontrib>Onbasilar, İlyas</creatorcontrib><creatorcontrib>Akyol, Asli</creatorcontrib><title>Maternal Low Quality Protein Diet Alters Plasma Amino Acid Concentrations of Weaning Rats</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Several studies have indicated the influence of a maternal low protein diet on the fetus. However, the effect of a maternal low quality protein diet on fetal growth and development is largely unknown. Wistar rats (11 weeks old) were mated and maintained on either a chow diet with 20% casein (n = 6) as the control group (C), or a low quality protein diet with 20% wheat gluten (n = 7) as the experimental group (WG) through gestation and lactation. Maternal body weights were similar in both groups throughout the study. Birth weights were not influenced by maternal diet and offspring body weights during lactation were similar between the groups. Offspring's plasma amino acid profiles showed that plasma methionine, glutamine and lysine were significantly lower and aspartic acid, ornithine and glycine-proline were significantly higher in the WG. Plant based protein comprises an important part of protein intake in developing countries. It is well-known that these diets can be inadequate in terms of essential amino acids. The current study shows differential effects of a maternal low quality protein diet on the offspring's plasma amino acids. Future studies will examine further aspects of the influence of maternal low quality protein diets on fetal growth and development.</description><subject>amino acid composition</subject><subject>Amino acids</subject><subject>Amino Acids - blood</subject><subject>Animal Nutritional Physiological Phenomena</subject><subject>Animals</subject><subject>Aspartic acid</subject><subject>birth weight</subject><subject>Breastfeeding & lactation</subject><subject>Casein</subject><subject>Developing countries</subject><subject>Diet</subject><subject>Dietary Proteins - administration & dosage</subject><subject>Dietary Proteins - analysis</subject><subject>essential amino acids</subject><subject>Female</subject><subject>fetal development</subject><subject>fetus</subject><subject>Fetuses</subject><subject>Gestation</subject><subject>Glutamine</subject><subject>Gluten</subject><subject>Glycine</subject><subject>growth and development</subject><subject>laboratory animals</subject><subject>Lactation</subject><subject>LDCs</subject><subject>Low protein diet</subject><subject>Lysine</subject><subject>maternal nutrition</subject><subject>Maternal Nutritional Physiological Phenomena</subject><subject>Methionine</subject><subject>Nutrient deficiency</subject><subject>Offspring</subject><subject>Ornithine</subject><subject>Plant-based foods</subject><subject>Plasma</subject><subject>Pregnancy</subject><subject>progeny</subject><subject>Proline</subject><subject>protein intake</subject><subject>Proteins</subject><subject>Quality</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Supply & demand</subject><subject>Weaning</subject><subject>Wheat</subject><subject>wheat gluten</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkU1LxDAQhoMoKurBPyABL3pYTZNp2l6EZf2EFT9QxFPIplONtMnapIr_3i6ri3pxLjMwDy_vzEvIdsIOhCjYoeuyhKcpy5fIOmcZH0gJYvnHvEa2Qnhhs8pYJsUqWeNSCgFZuk4eL3XE1umajv07vel0beMHvW59ROvoscVIh3VPBHpd69BoOmys83RobElH3hl0sdXReheor-gDamfdE73VMWySlUrXAbe--ga5Pz25G50PxldnF6PheGBA8DhIeSEyo4FDJRAzYzBPJGACBas4sgKwLDiUvXEDE-CpKKs8z3sKimqSVig2yNFcd9pNGiznjmo1bW2j2w_ltVW_N84-qyf_pkAWjEnWC-x9CbT-tcMQVWODwbrWDn0XFOe5LIBx9j-aZABSJhxEj-7-QV98N3t0L5iwPJUCgPfU_pwyrQ-hxWrhO2FqFq9axNuzOz8PXZDfYYpPh2We2A</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Kabasakal Cetin, Arzu</creator><creator>Dasgin, Halil</creator><creator>Gülec, Atila</creator><creator>Onbasilar, İlyas</creator><creator>Akyol, Asli</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6301-6358</orcidid></search><sort><creationdate>20151201</creationdate><title>Maternal Low Quality Protein Diet Alters Plasma Amino Acid Concentrations of Weaning Rats</title><author>Kabasakal Cetin, Arzu ; Dasgin, Halil ; Gülec, Atila ; Onbasilar, İlyas ; Akyol, Asli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-52937ca424f3ee7cce8164e1490f2e094ed924d076c4b4253df888ce849fb5fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>amino acid composition</topic><topic>Amino acids</topic><topic>Amino Acids - blood</topic><topic>Animal Nutritional Physiological Phenomena</topic><topic>Animals</topic><topic>Aspartic acid</topic><topic>birth weight</topic><topic>Breastfeeding & lactation</topic><topic>Casein</topic><topic>Developing countries</topic><topic>Diet</topic><topic>Dietary Proteins - administration & dosage</topic><topic>Dietary Proteins - analysis</topic><topic>essential amino acids</topic><topic>Female</topic><topic>fetal development</topic><topic>fetus</topic><topic>Fetuses</topic><topic>Gestation</topic><topic>Glutamine</topic><topic>Gluten</topic><topic>Glycine</topic><topic>growth and development</topic><topic>laboratory animals</topic><topic>Lactation</topic><topic>LDCs</topic><topic>Low protein diet</topic><topic>Lysine</topic><topic>maternal nutrition</topic><topic>Maternal Nutritional Physiological Phenomena</topic><topic>Methionine</topic><topic>Nutrient deficiency</topic><topic>Offspring</topic><topic>Ornithine</topic><topic>Plant-based foods</topic><topic>Plasma</topic><topic>Pregnancy</topic><topic>progeny</topic><topic>Proline</topic><topic>protein intake</topic><topic>Proteins</topic><topic>Quality</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Supply & demand</topic><topic>Weaning</topic><topic>Wheat</topic><topic>wheat gluten</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kabasakal Cetin, Arzu</creatorcontrib><creatorcontrib>Dasgin, Halil</creatorcontrib><creatorcontrib>Gülec, Atila</creatorcontrib><creatorcontrib>Onbasilar, İlyas</creatorcontrib><creatorcontrib>Akyol, Asli</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kabasakal Cetin, Arzu</au><au>Dasgin, Halil</au><au>Gülec, Atila</au><au>Onbasilar, İlyas</au><au>Akyol, Asli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal Low Quality Protein Diet Alters Plasma Amino Acid Concentrations of Weaning Rats</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>7</volume><issue>12</issue><spage>9847</spage><epage>9859</epage><pages>9847-9859</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Several studies have indicated the influence of a maternal low protein diet on the fetus. However, the effect of a maternal low quality protein diet on fetal growth and development is largely unknown. Wistar rats (11 weeks old) were mated and maintained on either a chow diet with 20% casein (n = 6) as the control group (C), or a low quality protein diet with 20% wheat gluten (n = 7) as the experimental group (WG) through gestation and lactation. Maternal body weights were similar in both groups throughout the study. Birth weights were not influenced by maternal diet and offspring body weights during lactation were similar between the groups. Offspring's plasma amino acid profiles showed that plasma methionine, glutamine and lysine were significantly lower and aspartic acid, ornithine and glycine-proline were significantly higher in the WG. Plant based protein comprises an important part of protein intake in developing countries. It is well-known that these diets can be inadequate in terms of essential amino acids. The current study shows differential effects of a maternal low quality protein diet on the offspring's plasma amino acids. Future studies will examine further aspects of the influence of maternal low quality protein diets on fetal growth and development.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>26633475</pmid><doi>10.3390/nu7125508</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-6301-6358</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | amino acid composition Amino acids Amino Acids - blood Animal Nutritional Physiological Phenomena Animals Aspartic acid birth weight Breastfeeding & lactation Casein Developing countries Diet Dietary Proteins - administration & dosage Dietary Proteins - analysis essential amino acids Female fetal development fetus Fetuses Gestation Glutamine Gluten Glycine growth and development laboratory animals Lactation LDCs Low protein diet Lysine maternal nutrition Maternal Nutritional Physiological Phenomena Methionine Nutrient deficiency Offspring Ornithine Plant-based foods Plasma Pregnancy progeny Proline protein intake Proteins Quality Rats Rats, Wistar Supply & demand Weaning Wheat wheat gluten |
| title | Maternal Low Quality Protein Diet Alters Plasma Amino Acid Concentrations of Weaning Rats |
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