Super Enhancers in Cancers, Complex Disease, and Developmental Disorders

Super Enhancers in Cancers, Complex Disease, and Developmental Disorders

Recently, unique areas of transcriptional regulation termed super-enhancers have been identified and implicated in human disease. Defined by their magnitude of size, transcription factor density, and binding of transcriptional machinery, super-enhancers have been associated with genes driving cell d...

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Veröffentlicht in:Genes 2015-11, Vol.6 (4), p.1183-1200
Hauptverfasser: Niederriter, Adrienne R, Varshney, Arushi, Parker, Stephen C J, Martin, Donna M
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container_title Genes
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creator Niederriter, Adrienne R
Varshney, Arushi
Parker, Stephen C J
Martin, Donna M
description Recently, unique areas of transcriptional regulation termed super-enhancers have been identified and implicated in human disease. Defined by their magnitude of size, transcription factor density, and binding of transcriptional machinery, super-enhancers have been associated with genes driving cell differentiation. While their functions are not completely understood, it is clear that these regions driving high-level transcription are susceptible to perturbation, and trait-associated single nucleotide polymorphisms (SNPs) occur within super-enhancers of disease-relevant cell types. Here we review evidence for super-enhancer involvement in cancers, complex diseases, and developmental disorders and discuss interactions between super-enhancers and cofactors/chromatin regulators.
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title Super Enhancers in Cancers, Complex Disease, and Developmental Disorders
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