Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma
Baicalin (BA) is a flavonoid compound purified from Scutellaria baicalensis Georgi and has been shown to possess a potent inhibitory activity against viruses. However, the role of BA in anti-influenza virus has not been extensively studied, and the immunological mechanism of BA in antiviral activity...
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| Veröffentlicht in: | BioMed research international 2015-01, Vol.2015 (2015), p.1-11 |
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| description | Baicalin (BA) is a flavonoid compound purified from Scutellaria baicalensis Georgi and has been shown to possess a potent inhibitory activity against viruses. However, the role of BA in anti-influenza virus has not been extensively studied, and the immunological mechanism of BA in antiviral activity remains unknown. Here, we observed that BA could protect mice from infection by influenza virus A/PR/8/34 (H1N1), associated with increasing IFN-γ production, but presented no effects in IFN-γ or IFN-γ receptor deficient mice. Further study indicated that BA could inhibit A/PR/8/34 replication through IFN-γ in human PBMC. Moreover, BA can directly induce IFN-γ production in human CD4+ and CD8+ T cells and NK cells, and activate JAK/STAT-1 signaling pathway. Collectively, BA exhibited anti-influenza virus A (H1N1) activity in vitro and in vivo as a potent inducer of IFN-γ in major IFN-γ producing cells. |
| doi_str_mv | 10.1155/2015/263630 |
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However, the role of BA in anti-influenza virus has not been extensively studied, and the immunological mechanism of BA in antiviral activity remains unknown. Here, we observed that BA could protect mice from infection by influenza virus A/PR/8/34 (H1N1), associated with increasing IFN-γ production, but presented no effects in IFN-γ or IFN-γ receptor deficient mice. Further study indicated that BA could inhibit A/PR/8/34 replication through IFN-γ in human PBMC. Moreover, BA can directly induce IFN-γ production in human CD4+ and CD8+ T cells and NK cells, and activate JAK/STAT-1 signaling pathway. Collectively, BA exhibited anti-influenza virus A (H1N1) activity in vitro and in vivo as a potent inducer of IFN-γ in major IFN-γ producing cells.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2015/263630</identifier><identifier>PMID: 26783516</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Animals ; Antiviral Agents - administration & dosage ; Automation ; Bioflavonoids ; Care and treatment ; CD4-Positive T-Lymphocytes - drug effects ; CD4-Positive T-Lymphocytes - immunology ; CD8-Positive T-Lymphocytes - drug effects ; CD8-Positive T-Lymphocytes - immunology ; Chinese medicine ; Flavones ; Flavonoids ; Flavonoids - administration & dosage ; Health aspects ; Humans ; Immunology ; Infections ; Influenza ; Influenza A virus ; Influenza A Virus, H1N1 Subtype - drug effects ; Influenza A Virus, H1N1 Subtype - immunology ; Influenza A Virus, H1N1 Subtype - pathogenicity ; Interferon-gamma - biosynthesis ; Interferon-gamma - genetics ; Killer Cells, Natural - drug effects ; Killer Cells, Natural - immunology ; Laboratories ; Leukocytes, Mononuclear - drug effects ; Leukocytes, Mononuclear - immunology ; Lungs ; Lymphocytes ; Mice ; Prevention ; Rodents ; Scullcap ; Scutellaria baicalensis ; Signal Transduction - drug effects ; Studies ; Viral infections ; Viruses</subject><ispartof>BioMed research international, 2015-01, Vol.2015 (2015), p.1-11</ispartof><rights>Copyright © 2015 Ming Chu et al.</rights><rights>COPYRIGHT 2015 John Wiley & Sons, Inc.</rights><rights>Copyright © 2015 Ming Chu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2015 Ming Chu et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c594t-b8efae646ecd472265c1cd79b45683bad0c04a1088bd231bb458c9761b9785a43</citedby><cites>FETCH-LOGICAL-c594t-b8efae646ecd472265c1cd79b45683bad0c04a1088bd231bb458c9761b9785a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689896/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689896/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26783516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Tannock, Gregory</contributor><creatorcontrib>Chu, Zheng-yun</creatorcontrib><creatorcontrib>Zhang, Ming-bo</creatorcontrib><creatorcontrib>Xu, Lan</creatorcontrib><creatorcontrib>Chu, Ming</creatorcontrib><creatorcontrib>Wang, Yue-dan</creatorcontrib><title>Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Baicalin (BA) is a flavonoid compound purified from Scutellaria baicalensis Georgi and has been shown to possess a potent inhibitory activity against viruses. However, the role of BA in anti-influenza virus has not been extensively studied, and the immunological mechanism of BA in antiviral activity remains unknown. Here, we observed that BA could protect mice from infection by influenza virus A/PR/8/34 (H1N1), associated with increasing IFN-γ production, but presented no effects in IFN-γ or IFN-γ receptor deficient mice. Further study indicated that BA could inhibit A/PR/8/34 replication through IFN-γ in human PBMC. Moreover, BA can directly induce IFN-γ production in human CD4+ and CD8+ T cells and NK cells, and activate JAK/STAT-1 signaling pathway. Collectively, BA exhibited anti-influenza virus A (H1N1) activity in vitro and in vivo as a potent inducer of IFN-γ in major IFN-γ producing cells.</description><subject>Animals</subject><subject>Antiviral Agents - administration & dosage</subject><subject>Automation</subject><subject>Bioflavonoids</subject><subject>Care and treatment</subject><subject>CD4-Positive T-Lymphocytes - drug effects</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD8-Positive T-Lymphocytes - drug effects</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Chinese medicine</subject><subject>Flavones</subject><subject>Flavonoids</subject><subject>Flavonoids - administration & dosage</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immunology</subject><subject>Infections</subject><subject>Influenza</subject><subject>Influenza A virus</subject><subject>Influenza A Virus, H1N1 Subtype - drug effects</subject><subject>Influenza A Virus, H1N1 Subtype - immunology</subject><subject>Influenza A Virus, H1N1 Subtype - pathogenicity</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Interferon-gamma - genetics</subject><subject>Killer Cells, Natural - drug effects</subject><subject>Killer Cells, Natural - immunology</subject><subject>Laboratories</subject><subject>Leukocytes, Mononuclear - drug effects</subject><subject>Leukocytes, Mononuclear - immunology</subject><subject>Lungs</subject><subject>Lymphocytes</subject><subject>Mice</subject><subject>Prevention</subject><subject>Rodents</subject><subject>Scullcap</subject><subject>Scutellaria baicalensis</subject><subject>Signal Transduction - drug effects</subject><subject>Studies</subject><subject>Viral infections</subject><subject>Viruses</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkdFv1SAUxhvj4pZtT74bEl-MphMKnNIXk-vithsXNUZ9JaeUbiwtbNBq9K8fzd2u06cRAgR-5-Oc8xXFc0aPGJPybUVZXoADp0-KvYozUQIT7On2zPlucZjSFc1DMaANPCt2K6gVlwz2io9fw2BJ6Ml7dAYH50meKz-5cu37Ybb-D5IfLs6JrAgmguRLmKyfyNp3s7FxiVyffCpPcRzxoNjpcUj28G7fL76ffPh2fFaefz5dH6_OSyMbMZWtsj1aEGBNJ-qqAmmY6eqmFRIUb7GjhgpkVKm2y0W0-V6ZpgbWNrWSKPh-8W6jez23o-1MzifioK-jGzH-1gGd_vfFu0t9EX5qAapRDWSBV3cCMdzMNk16dMnYYUBvw5w0qyH_3rBKPgKVqhJAYUFf_odehTn63ImFohykpPVf6gIHq53vQ07RLKJ6lQvNDtW8ytSbDWViSCnaflsdo3oxXi_G643xmX7xsCFb9t7mDLzeAJfOd_jLPU7NZiRb9QCWQjHKbwE0S7po</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Chu, Zheng-yun</creator><creator>Zhang, Ming-bo</creator><creator>Xu, Lan</creator><creator>Chu, Ming</creator><creator>Wang, Yue-dan</creator><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7T2</scope><scope>7U2</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150101</creationdate><title>Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma</title><author>Chu, Zheng-yun ; Zhang, Ming-bo ; Xu, Lan ; Chu, Ming ; Wang, Yue-dan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c594t-b8efae646ecd472265c1cd79b45683bad0c04a1088bd231bb458c9761b9785a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Antiviral Agents - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chu, Zheng-yun</au><au>Zhang, Ming-bo</au><au>Xu, Lan</au><au>Chu, Ming</au><au>Wang, Yue-dan</au><au>Tannock, Gregory</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>2015</volume><issue>2015</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Baicalin (BA) is a flavonoid compound purified from Scutellaria baicalensis Georgi and has been shown to possess a potent inhibitory activity against viruses. However, the role of BA in anti-influenza virus has not been extensively studied, and the immunological mechanism of BA in antiviral activity remains unknown. Here, we observed that BA could protect mice from infection by influenza virus A/PR/8/34 (H1N1), associated with increasing IFN-γ production, but presented no effects in IFN-γ or IFN-γ receptor deficient mice. Further study indicated that BA could inhibit A/PR/8/34 replication through IFN-γ in human PBMC. Moreover, BA can directly induce IFN-γ production in human CD4+ and CD8+ T cells and NK cells, and activate JAK/STAT-1 signaling pathway. Collectively, BA exhibited anti-influenza virus A (H1N1) activity in vitro and in vivo as a potent inducer of IFN-γ in major IFN-γ producing cells.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>26783516</pmid><doi>10.1155/2015/263630</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antiviral Agents - administration & dosage Automation Bioflavonoids Care and treatment CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Chinese medicine Flavones Flavonoids Flavonoids - administration & dosage Health aspects Humans Immunology Infections Influenza Influenza A virus Influenza A Virus, H1N1 Subtype - drug effects Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H1N1 Subtype - pathogenicity Interferon-gamma - biosynthesis Interferon-gamma - genetics Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Laboratories Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Lungs Lymphocytes Mice Prevention Rodents Scullcap Scutellaria baicalensis Signal Transduction - drug effects Studies Viral infections Viruses |
| title | Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma |
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