L-type Ca2+ channel blockade with antihypertensive medication disrupts VTA synaptic plasticity and drug-associated contextual memory

Drug addiction is driven, in part, by powerful and enduring memories of sensory cues associated with drug intake. As such, relapse to drug use during abstinence is frequently triggered by an encounter with drug-associated cues, including the drug itself. L-type Ca 2+ channels (LTCCs) are known to re...

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Veröffentlicht in:	Molecular psychiatry 2016-03, Vol.21 (3), p.394-402
Hauptverfasser:	Degoulet, M, Stelly, C E, Ahn, K-C, Morikawa, H
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378 9/74 Abstinence Addictions Alcohol Analysis of Variance Animals Antihypertensive Agents - pharmacology Antihypertensives Behavioral Sciences Biological Psychology Brain research Brain slice preparation Calcium Channel Blockers - pharmacology Calcium channels Calcium channels (L-type) Calcium channels (voltage-gated) Cocaine Cocaine - pharmacology Conditioning, Operant - drug effects Dopamine Drug addiction Drug Interactions Drug use Electric Stimulation Ethanol Excitatory Amino Acid Agents - pharmacology Extinction, Psychological - drug effects Glutamate receptors Glutamatergic transmission Glutamic acid receptors (ionotropic) In Vitro Techniques Isradipine - pharmacology Long-term potentiation Long-Term Potentiation - drug effects Male Medicine Medicine & Public Health Memory Memory - drug effects N-Methyl-D-aspartic acid receptors Neurons Neuroplasticity Neurosciences Neurotransmitter Agents - pharmacology original-article Patch-Clamp Techniques Pharmacotherapy Place preference conditioning Psychiatry Rats Rats, Sprague-Dawley Reinstatement Synaptic plasticity Ventral Tegmental Area - drug effects Ventral tegmentum Withdrawal
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