New markers for tracking endoderm induction and hepatocyte differentiation from human pluripotent stem cells

The efficient generation of hepatocytes from human pluripotent stem cells (hPSCs) requires the induction of a proper endoderm population, broadly characterized by the expression of the cell surface marker CXCR4. Strategies to identify and isolate endoderm subpopulations predisposed to the liver fate...

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Veröffentlicht in:	Development (Cambridge) 2015-12, Vol.142 (24), p.4253-4265
Hauptverfasser:	Holtzinger, Audrey, Streeter, Philip R, Sarangi, Farida, Hillborn, Scott, Niapour, Maryam, Ogawa, Shinichiro, Keller, Gordon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - metabolism Biomarkers - metabolism Cell Differentiation Cell Line Cell Separation Ectoderm - cytology Endoderm - cytology Hepatocytes - cytology Hepatocytes - metabolism Human Embryonic Stem Cells - cytology Human Embryonic Stem Cells - metabolism Humans Kinetics Mesoderm - cytology Mice, Inbred BALB C Pancreas - embryology Pluripotent Stem Cells - cytology Pluripotent Stem Cells - metabolism Staining and Labeling Stem Cells and Regeneration
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