The MAGE protein family and cancer
The Melanoma Antigen Gene (MAGE) protein family is a large, highly conserved group of proteins that share a common MAGE homology domain. Intriguingly, many MAGE proteins are restricted in expression to reproductive tissues, but are aberrantly expressed in a wide variety of cancer types. Originally d...
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| Veröffentlicht in: | Current opinion in cell biology 2015-12, Vol.37, p.1-8 |
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| container_title | Current opinion in cell biology |
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| creator | Weon, Jenny L Potts, Patrick Ryan |
| description | The Melanoma Antigen Gene (MAGE) protein family is a large, highly conserved group of proteins that share a common MAGE homology domain. Intriguingly, many MAGE proteins are restricted in expression to reproductive tissues, but are aberrantly expressed in a wide variety of cancer types. Originally discovered as antigens on tumor cells and developed as cancer immunotherapy targets, recent literature suggests a more prominent role for MAGEs in driving tumorigenesis. This review will highlight recent developments into the function of MAGEs as oncogenes, their mechanisms of action in regulation of ubiquitin ligases, and outstanding questions in the field. |
| doi_str_mv | 10.1016/j.ceb.2015.08.002 |
| format | Article |
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| ispartof | Current opinion in cell biology, 2015-12, Vol.37, p.1-8 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Antigens, Neoplasm - metabolism Disease Progression Humans Immunotherapy Internal Medicine Neoplasm Proteins - metabolism Neoplasms - metabolism Neoplasms - pathology Neoplasms - therapy Neoplastic Stem Cells |
| title | The MAGE protein family and cancer |
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