Characteristics of α-Gal epitope, anti-Gal antibody, α1,3 galactosyltransferase and its clinical exploitation (Review)

The α-Gal epitope (Galα1,3Galα1,4GlcNAc-R) is ubiquitously presented in non-primate mammals, marsupials and New World Monkeys, but it is absent in humans, apes and Old World monkeys. However, the anti-Gal antibody (~1% of immunoglobulins) is naturally generated in human, and is found as the immunogl...

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Veröffentlicht in:	International journal of molecular medicine 2016-01, Vol.37 (1), p.11-20
Hauptverfasser:	HUAI, GUOLI, QI, PING, YANG, HONGJI, WANG, YI
Format:	Artikel
Sprache:	eng
Schlagworte:	3GT Analysis Animals anti-Gal antibody Antibodies - immunology Apes Base Sequence Biological Evolution Carbohydrates Chromosomes clinical exploitation Enzymes Epitopes - chemistry Epitopes - immunology Experiments Galactosyltransferases - chemistry Galactosyltransferases - genetics Galactosyltransferases - immunology Gene Knockout Techniques Genes Genetic aspects Genetic engineering Glycoproteins Graft Rejection - genetics Graft Rejection - immunology HIV Human immunodeficiency virus Humans Immunoglobulin A Immunoglobulin G Immunotherapy Immunotherapy - methods Lymphoma mammalian evolution Mammals Molecular Sequence Data Monkeys & apes Nanoparticles Neoplasms - genetics Neoplasms - immunology Neoplasms - therapy Physiological aspects Regeneration Rodents Tissue engineering Transplantation, Heterologous - methods Trisaccharides - chemistry Trisaccharides - immunology Vaccines Wound Healing α-gal epitope α1
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