Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche

Multiple myeloma is largely incurable, despite development of therapies that target myeloma cell-intrinsic pathways. Disease relapse is thought to originate from dormant myeloma cells, localized in specialized niches, which resist therapy and repopulate the tumour. However, little is known about the...

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Veröffentlicht in:	Nature communications 2015-12, Vol.6 (1), p.8983-8983, Article 8983
Hauptverfasser:	Lawson, Michelle A., McDonald, Michelle M., Kovacic, Natasa, Hua Khoo, Weng, Terry, Rachael L., Down, Jenny, Kaplan, Warren, Paton-Hough, Julia, Fellows, Clair, Pettitt, Jessica A., Neil Dear, T., Van Valckenborgh, Els, Baldock, Paul A., Rogers, Michael J., Eaton, Colby L., Vanderkerken, Karin, Pettit, Allison R., Quinn, Julian M. W., Zannettino, Andrew C. W., Phan, Tri Giang, Croucher, Peter I.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/31 14/63 14/69 38/39 38/61 631/532/2139 631/67/1990/804 692/308/2171 692/4023/1671 Aged Aged, 80 and over Animals Bone marrow Bone Remodeling - physiology Cancer therapies Cell Line, Tumor Chemotherapy Cloning Coculture Techniques Disease resistance Dormancy Drug resistance Female Humanities and Social Sciences Humans Male Medical research Mice Mice, Inbred Strains Microscopy Middle Aged multidisciplinary Multiple myeloma Multiple Myeloma - metabolism Osteoblasts - physiology Osteoclasts Osteoclasts - physiology Research centers Science Science (multidisciplinary) Stem cells
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