Insights into the structure and function of membrane-integrated processive glycosyltransferases
•Membrane-integrated processive glycosyltransferases.•Synthesis of high molecular weight polysaccharides.•Polymer synthesis and membrane translocation are coupled.•Processive glycosyltransferases share structural and functional traits. Complex carbohydrates perform essential functions in life, inclu...
Gespeichert in:
| Veröffentlicht in: | Current opinion in structural biology 2015-10, Vol.34, p.78-86 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 86 |
|---|---|
| container_issue | |
| container_start_page | 78 |
| container_title | Current opinion in structural biology |
| container_volume | 34 |
| creator | Bi, Yunchen Hubbard, Caitlin Purushotham, Pallinti Zimmer, Jochen |
| description | •Membrane-integrated processive glycosyltransferases.•Synthesis of high molecular weight polysaccharides.•Polymer synthesis and membrane translocation are coupled.•Processive glycosyltransferases share structural and functional traits.
Complex carbohydrates perform essential functions in life, including energy storage, cell signaling, protein targeting, quality control, as well as supporting cell structure and stability. Extracellular polysaccharides (EPS) represent mainly structural polymers and are found in essentially all kingdoms of life. For example, EPS are important biofilm and capsule components in bacteria, represent major constituents in cell walls of fungi, algae, arthropods and plants, and modulate the extracellular matrix in vertebrates. Different mechanisms evolved by which EPS are synthesized. Here, we review the structures and functions of membrane-integrated processive glycosyltransferases (GTs) implicated in the synthesis and secretion of chitin, alginate, hyaluronan and poly-N-acetylglucosamine (PNAG). |
| doi_str_mv | 10.1016/j.sbi.2015.07.008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4684724</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0959440X15001062</els_id><sourcerecordid>1750431933</sourcerecordid><originalsourceid>FETCH-LOGICAL-c478t-2d5241997346136ce2c510ee93f65b5dcc34c969f869a9b0addf78b760841e443</originalsourceid><addsrcrecordid>eNp9kUGL1DAYhoO4uOPqD_AixdNe2k2aNGkQBFlWXVjworC30KZfZzK0yZgvHZh_b8qsi1485ZDne_Pmewh5x2jFKJM3-wp7V9WUNRVVFaXtC7JhrdIl5fzxJdlQ3ehSCPp4SV4j7imlkon2FbmsJRc1E3xDzL1Ht90lLJxPoUg7KDDFxaYlQtH5oRgXb5MLvghjMcPcx85DmVnYxi7BUBxisIDojlBsp5MNeJpSZnCE2CHgG3IxdhPC26fzivz8cvfj9lv58P3r_e3nh9IK1aayHppaMK0VF5JxaaG2DaMAmo-y6ZvBWi6slnpspe50T7thGFXbK0lbwUAIfkU-nXMPSz_DYMHnFpM5RDd38WRC58y_N97tzDYcjZCtUPUa8OEcEDA5g9YlsDsbvAebDONCNHSFrp9eieHXApjM7NDCNOWlhAUNUyvFNOcZZWfUxoAYYXzuwqhZ7Zm9yfbMas9QZbK9PPP-7088T_zRlYGPZwDyKo8O4loUvIXBxbXnENx_4n8Dq0etcA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1750431933</pqid></control><display><type>article</type><title>Insights into the structure and function of membrane-integrated processive glycosyltransferases</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Bi, Yunchen ; Hubbard, Caitlin ; Purushotham, Pallinti ; Zimmer, Jochen</creator><creatorcontrib>Bi, Yunchen ; Hubbard, Caitlin ; Purushotham, Pallinti ; Zimmer, Jochen ; Univ. of Virginia, Charlottesville, VA (United States) ; Energy Frontier Research Centers (EFRC) (United States). Center for Lignocellulose Structure and Formation (CLSF)</creatorcontrib><description>•Membrane-integrated processive glycosyltransferases.•Synthesis of high molecular weight polysaccharides.•Polymer synthesis and membrane translocation are coupled.•Processive glycosyltransferases share structural and functional traits.
Complex carbohydrates perform essential functions in life, including energy storage, cell signaling, protein targeting, quality control, as well as supporting cell structure and stability. Extracellular polysaccharides (EPS) represent mainly structural polymers and are found in essentially all kingdoms of life. For example, EPS are important biofilm and capsule components in bacteria, represent major constituents in cell walls of fungi, algae, arthropods and plants, and modulate the extracellular matrix in vertebrates. Different mechanisms evolved by which EPS are synthesized. Here, we review the structures and functions of membrane-integrated processive glycosyltransferases (GTs) implicated in the synthesis and secretion of chitin, alginate, hyaluronan and poly-N-acetylglucosamine (PNAG).</description><identifier>ISSN: 0959-440X</identifier><identifier>EISSN: 1879-033X</identifier><identifier>DOI: 10.1016/j.sbi.2015.07.008</identifier><identifier>PMID: 26342143</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; BASIC BIOLOGICAL SCIENCES ; Biopolymers - chemistry ; Biopolymers - metabolism ; Chitin Synthase - chemistry ; Chitin Synthase - metabolism ; Glycosyltransferases - chemistry ; Glycosyltransferases - metabolism ; Humans ; Membrane Proteins - chemistry ; Membrane Proteins - metabolism ; Molecular Weight ; Polysaccharides - chemistry ; Polysaccharides - metabolism ; Protein Interaction Domains and Motifs ; Protein Processing, Post-Translational ; Structure-Activity Relationship</subject><ispartof>Current opinion in structural biology, 2015-10, Vol.34, p.78-86</ispartof><rights>2015</rights><rights>Copyright © 2015. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-2d5241997346136ce2c510ee93f65b5dcc34c969f869a9b0addf78b760841e443</citedby><cites>FETCH-LOGICAL-c478t-2d5241997346136ce2c510ee93f65b5dcc34c969f869a9b0addf78b760841e443</cites><orcidid>0000-0001-9037-6324 ; 0000000190376324</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0959440X15001062$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26342143$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/servlets/purl/1344504$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Bi, Yunchen</creatorcontrib><creatorcontrib>Hubbard, Caitlin</creatorcontrib><creatorcontrib>Purushotham, Pallinti</creatorcontrib><creatorcontrib>Zimmer, Jochen</creatorcontrib><creatorcontrib>Univ. of Virginia, Charlottesville, VA (United States)</creatorcontrib><creatorcontrib>Energy Frontier Research Centers (EFRC) (United States). Center for Lignocellulose Structure and Formation (CLSF)</creatorcontrib><title>Insights into the structure and function of membrane-integrated processive glycosyltransferases</title><title>Current opinion in structural biology</title><addtitle>Curr Opin Struct Biol</addtitle><description>•Membrane-integrated processive glycosyltransferases.•Synthesis of high molecular weight polysaccharides.•Polymer synthesis and membrane translocation are coupled.•Processive glycosyltransferases share structural and functional traits.
Complex carbohydrates perform essential functions in life, including energy storage, cell signaling, protein targeting, quality control, as well as supporting cell structure and stability. Extracellular polysaccharides (EPS) represent mainly structural polymers and are found in essentially all kingdoms of life. For example, EPS are important biofilm and capsule components in bacteria, represent major constituents in cell walls of fungi, algae, arthropods and plants, and modulate the extracellular matrix in vertebrates. Different mechanisms evolved by which EPS are synthesized. Here, we review the structures and functions of membrane-integrated processive glycosyltransferases (GTs) implicated in the synthesis and secretion of chitin, alginate, hyaluronan and poly-N-acetylglucosamine (PNAG).</description><subject>Animals</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>Biopolymers - chemistry</subject><subject>Biopolymers - metabolism</subject><subject>Chitin Synthase - chemistry</subject><subject>Chitin Synthase - metabolism</subject><subject>Glycosyltransferases - chemistry</subject><subject>Glycosyltransferases - metabolism</subject><subject>Humans</subject><subject>Membrane Proteins - chemistry</subject><subject>Membrane Proteins - metabolism</subject><subject>Molecular Weight</subject><subject>Polysaccharides - chemistry</subject><subject>Polysaccharides - metabolism</subject><subject>Protein Interaction Domains and Motifs</subject><subject>Protein Processing, Post-Translational</subject><subject>Structure-Activity Relationship</subject><issn>0959-440X</issn><issn>1879-033X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUGL1DAYhoO4uOPqD_AixdNe2k2aNGkQBFlWXVjworC30KZfZzK0yZgvHZh_b8qsi1485ZDne_Pmewh5x2jFKJM3-wp7V9WUNRVVFaXtC7JhrdIl5fzxJdlQ3ehSCPp4SV4j7imlkon2FbmsJRc1E3xDzL1Ht90lLJxPoUg7KDDFxaYlQtH5oRgXb5MLvghjMcPcx85DmVnYxi7BUBxisIDojlBsp5MNeJpSZnCE2CHgG3IxdhPC26fzivz8cvfj9lv58P3r_e3nh9IK1aayHppaMK0VF5JxaaG2DaMAmo-y6ZvBWi6slnpspe50T7thGFXbK0lbwUAIfkU-nXMPSz_DYMHnFpM5RDd38WRC58y_N97tzDYcjZCtUPUa8OEcEDA5g9YlsDsbvAebDONCNHSFrp9eieHXApjM7NDCNOWlhAUNUyvFNOcZZWfUxoAYYXzuwqhZ7Zm9yfbMas9QZbK9PPP-7088T_zRlYGPZwDyKo8O4loUvIXBxbXnENx_4n8Dq0etcA</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Bi, Yunchen</creator><creator>Hubbard, Caitlin</creator><creator>Purushotham, Pallinti</creator><creator>Zimmer, Jochen</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OIOZB</scope><scope>OTOTI</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9037-6324</orcidid><orcidid>https://orcid.org/0000000190376324</orcidid></search><sort><creationdate>20151001</creationdate><title>Insights into the structure and function of membrane-integrated processive glycosyltransferases</title><author>Bi, Yunchen ; Hubbard, Caitlin ; Purushotham, Pallinti ; Zimmer, Jochen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-2d5241997346136ce2c510ee93f65b5dcc34c969f869a9b0addf78b760841e443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>Biopolymers - chemistry</topic><topic>Biopolymers - metabolism</topic><topic>Chitin Synthase - chemistry</topic><topic>Chitin Synthase - metabolism</topic><topic>Glycosyltransferases - chemistry</topic><topic>Glycosyltransferases - metabolism</topic><topic>Humans</topic><topic>Membrane Proteins - chemistry</topic><topic>Membrane Proteins - metabolism</topic><topic>Molecular Weight</topic><topic>Polysaccharides - chemistry</topic><topic>Polysaccharides - metabolism</topic><topic>Protein Interaction Domains and Motifs</topic><topic>Protein Processing, Post-Translational</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bi, Yunchen</creatorcontrib><creatorcontrib>Hubbard, Caitlin</creatorcontrib><creatorcontrib>Purushotham, Pallinti</creatorcontrib><creatorcontrib>Zimmer, Jochen</creatorcontrib><creatorcontrib>Univ. of Virginia, Charlottesville, VA (United States)</creatorcontrib><creatorcontrib>Energy Frontier Research Centers (EFRC) (United States). Center for Lignocellulose Structure and Formation (CLSF)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV - Hybrid</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current opinion in structural biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bi, Yunchen</au><au>Hubbard, Caitlin</au><au>Purushotham, Pallinti</au><au>Zimmer, Jochen</au><aucorp>Univ. of Virginia, Charlottesville, VA (United States)</aucorp><aucorp>Energy Frontier Research Centers (EFRC) (United States). Center for Lignocellulose Structure and Formation (CLSF)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insights into the structure and function of membrane-integrated processive glycosyltransferases</atitle><jtitle>Current opinion in structural biology</jtitle><addtitle>Curr Opin Struct Biol</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>34</volume><spage>78</spage><epage>86</epage><pages>78-86</pages><issn>0959-440X</issn><eissn>1879-033X</eissn><abstract>•Membrane-integrated processive glycosyltransferases.•Synthesis of high molecular weight polysaccharides.•Polymer synthesis and membrane translocation are coupled.•Processive glycosyltransferases share structural and functional traits.
Complex carbohydrates perform essential functions in life, including energy storage, cell signaling, protein targeting, quality control, as well as supporting cell structure and stability. Extracellular polysaccharides (EPS) represent mainly structural polymers and are found in essentially all kingdoms of life. For example, EPS are important biofilm and capsule components in bacteria, represent major constituents in cell walls of fungi, algae, arthropods and plants, and modulate the extracellular matrix in vertebrates. Different mechanisms evolved by which EPS are synthesized. Here, we review the structures and functions of membrane-integrated processive glycosyltransferases (GTs) implicated in the synthesis and secretion of chitin, alginate, hyaluronan and poly-N-acetylglucosamine (PNAG).</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>26342143</pmid><doi>10.1016/j.sbi.2015.07.008</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-9037-6324</orcidid><orcidid>https://orcid.org/0000000190376324</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-440X |
| ispartof | Current opinion in structural biology, 2015-10, Vol.34, p.78-86 |
| issn | 0959-440X 1879-033X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4684724 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals BASIC BIOLOGICAL SCIENCES Biopolymers - chemistry Biopolymers - metabolism Chitin Synthase - chemistry Chitin Synthase - metabolism Glycosyltransferases - chemistry Glycosyltransferases - metabolism Humans Membrane Proteins - chemistry Membrane Proteins - metabolism Molecular Weight Polysaccharides - chemistry Polysaccharides - metabolism Protein Interaction Domains and Motifs Protein Processing, Post-Translational Structure-Activity Relationship |
| title | Insights into the structure and function of membrane-integrated processive glycosyltransferases |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T14%3A36%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Insights%20into%20the%20structure%20and%20function%20of%20membrane-integrated%20processive%20glycosyltransferases&rft.jtitle=Current%20opinion%20in%20structural%20biology&rft.au=Bi,%20Yunchen&rft.aucorp=Univ.%20of%20Virginia,%20Charlottesville,%20VA%20(United%20States)&rft.date=2015-10-01&rft.volume=34&rft.spage=78&rft.epage=86&rft.pages=78-86&rft.issn=0959-440X&rft.eissn=1879-033X&rft_id=info:doi/10.1016/j.sbi.2015.07.008&rft_dat=%3Cproquest_pubme%3E1750431933%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1750431933&rft_id=info:pmid/26342143&rft_els_id=S0959440X15001062&rfr_iscdi=true |