Graphene oxide inhibits hIAPP amyloid fibrillation and toxicity in insulin-producing NIT-1 cells

Human islet amyloid polypeptide (hIAPP or amylin) aggregation is directly associated with pancreatic β-cell death and subsequent insulin deficiency in type 2 diabetes (T2D). Since no cure is currently available for T2D, it is of great benefit to devise new anti-aggregation molecules, which protect β...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Physical chemistry chemical physics : PCCP 2016-01, Vol.18 (1), p.94-100
Hauptverfasser:	Nedumpully-Govindan, Praveen, Gurzov, Esteban N, Chen, Pengyu, Pilkington, Emily H, Stanley, William J, Litwak, Sara A, Davis, Thomas P, Ke, Pu Chun, Ding, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Agglomeration Binding Cell Line Computer simulation Dichroism Graphene Graphite - chemistry Graphite - pharmacology Humans Insulin - biosynthesis Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Islet Amyloid Polypeptide - antagonists & inhibitors Islet Amyloid Polypeptide - metabolism Molecular Dynamics Simulation Nanostructure Oxides - chemistry Oxides - pharmacology Protein Aggregates - drug effects Toxicity Transmission electron microscopy
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!