No evidence of association between subclinical thyroid disorders and common carotid intima medial thickness or atherosclerotic plaque
Abstract Background and aims Increased carotid artery intima-media thickness (IMT) and the presence of plaques have been shown to be predictors of cardiovascular disease. The cardiovascular risk in patients with overt thyroid diseases is related to increased risk of atherosclerosis, but there has be...
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| creator | Delitala, A.P Filigheddu, F Orrù, M AlGhatrif, M Steri, M Pilia, M.G Scuteri, A Lobina, M Piras, M.G Delitala, G Lakatta, E.G Schlessinger, D Cucca, F |
| description | Abstract Background and aims Increased carotid artery intima-media thickness (IMT) and the presence of plaques have been shown to be predictors of cardiovascular disease. The cardiovascular risk in patients with overt thyroid diseases is related to increased risk of atherosclerosis, but there has been no clear evidence about subclinical disorders. We have assessed whether subclinical thyroid dysfunction is associated with arterial thickening and plaque. Methods and results The SardiNIA study is a population-based survey on the Italian island of Sardinia. We reviewed data from 5815 subjects (aged 14–102 years), none of whom had overt hyperthyroidism or hypothyroidism or was taking thyroid medication. Serum thyrotropin (TSH), free thyroxine, together with carotid ultrasound IMT and the presence of common carotid plaques were analysed in all subjects. Possible association of IMT and carotid plaques with thyroid parameters was evaluated by univariate and multivariate analyses. IMT was significantly associated with age, sex, smoking, low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol, pulse pressure (PP), history of arterial hypertension, diabetes, and previous cardiovascular events (p = 0.001 or lower, R2 = 0.47). Carotid plaques were predicted by age, sex, LDL, PP, history of diabetes, previous cardiovascular events, and the use of statins (p = 0.029 or lower). Thyroid hormone was not predictive of carotid atherosclerosis when adjusted for confounders. Conclusion Thyroid hormone is not associated with increased IMT or with the presence of carotid artery plaque. Our data do not support the idea that treating subclinical disorders might help to prevent arterial remodelling or carotid atherosclerosis. |
| doi_str_mv | 10.1016/j.numecd.2015.09.001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4684424</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0939475315300922</els_id><sourcerecordid>1750429699</sourcerecordid><originalsourceid>FETCH-LOGICAL-c621t-8c240698e5a889059cf2c93062f2f14b1c237ca4d37a567e2896cd50b91ffc663</originalsourceid><addsrcrecordid>eNqFksuO1DAQRSMEYpqBP0DISzYd_IoTb5DQaHhII1gAa8tdrtDuSezGThr1B_DfOPTM8NjMyou6t3yrTlXVc0ZrRpl6tavDPCK4mlPW1FTXlLIH1Yo1mq5Fy_XDakW10GvZNuKsepLzjlLRUiEfV2dcKdZwLlfVz4-R4ME7DIAk9sTmHMHbycdANjj9QAwkzxsYfPBgBzJtjyl6R5zPMTlMmdjgCMRxLAawKU6l6MPkR0tGdP63xcN1wJxJTMROW0wxw4CLFMh-sN9nfFo96u2Q8dnNe159fXv55eL9-urTuw8Xb67WoDib1h1wSZXusLFdp2mjoeegBVW85z2TGwZctGClE61tVIu80wpcQzea9T0oJc6r16e--3lT0gGGKdnB7FOJm44mWm_-rQS_Nd_iwUjVScllafDypkGKJXeezOgz4DDYgHHOhhc0Qksu-L1S1jZUcq20LlJ5kkJZTU7Y3yVi1Cywzc6cYJsFtqHaFNjF9uLvae5Mt3T_jItlpwePyWTwC2nnE8JkXPT3_fB_g9tDuMYj5l2cUyi8DDOZG2o-Lwe33BtrBKWac_EL47TVYw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1750429699</pqid></control><display><type>article</type><title>No evidence of association between subclinical thyroid disorders and common carotid intima medial thickness or atherosclerotic plaque</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Delitala, A.P ; Filigheddu, F ; Orrù, M ; AlGhatrif, M ; Steri, M ; Pilia, M.G ; Scuteri, A ; Lobina, M ; Piras, M.G ; Delitala, G ; Lakatta, E.G ; Schlessinger, D ; Cucca, F</creator><creatorcontrib>Delitala, A.P ; Filigheddu, F ; Orrù, M ; AlGhatrif, M ; Steri, M ; Pilia, M.G ; Scuteri, A ; Lobina, M ; Piras, M.G ; Delitala, G ; Lakatta, E.G ; Schlessinger, D ; Cucca, F</creatorcontrib><description>Abstract Background and aims Increased carotid artery intima-media thickness (IMT) and the presence of plaques have been shown to be predictors of cardiovascular disease. The cardiovascular risk in patients with overt thyroid diseases is related to increased risk of atherosclerosis, but there has been no clear evidence about subclinical disorders. We have assessed whether subclinical thyroid dysfunction is associated with arterial thickening and plaque. Methods and results The SardiNIA study is a population-based survey on the Italian island of Sardinia. We reviewed data from 5815 subjects (aged 14–102 years), none of whom had overt hyperthyroidism or hypothyroidism or was taking thyroid medication. Serum thyrotropin (TSH), free thyroxine, together with carotid ultrasound IMT and the presence of common carotid plaques were analysed in all subjects. Possible association of IMT and carotid plaques with thyroid parameters was evaluated by univariate and multivariate analyses. IMT was significantly associated with age, sex, smoking, low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol, pulse pressure (PP), history of arterial hypertension, diabetes, and previous cardiovascular events (p = 0.001 or lower, R2 = 0.47). Carotid plaques were predicted by age, sex, LDL, PP, history of diabetes, previous cardiovascular events, and the use of statins (p = 0.029 or lower). Thyroid hormone was not predictive of carotid atherosclerosis when adjusted for confounders. Conclusion Thyroid hormone is not associated with increased IMT or with the presence of carotid artery plaque. Our data do not support the idea that treating subclinical disorders might help to prevent arterial remodelling or carotid atherosclerosis.</description><identifier>ISSN: 0939-4753</identifier><identifier>EISSN: 1590-3729</identifier><identifier>DOI: 10.1016/j.numecd.2015.09.001</identifier><identifier>PMID: 26615224</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Age Factors ; Aged ; Analysis of Variance ; Arterial remodelling ; Atherosclerosis ; blood serum ; Cardiovascular ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; carotid arteries ; Carotid Artery Diseases - diagnostic imaging ; Carotid Artery Diseases - epidemiology ; Carotid Intima-Media Thickness ; Carotid plaques ; Carotid Stenosis - diagnostic imaging ; Carotid Stenosis - epidemiology ; Comorbidity ; Confidence Intervals ; Cross-Sectional Studies ; diabetes ; drug therapy ; Female ; high density lipoprotein cholesterol ; Humans ; hypertension ; hyperthyroidism ; Hyperthyroidism - diagnosis ; Hyperthyroidism - epidemiology ; hypothyroidism ; Hypothyroidism - diagnosis ; Hypothyroidism - epidemiology ; Longitudinal Studies ; low density lipoprotein cholesterol ; Male ; metabolism ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; patients ; risk ; Risk Assessment ; Sardinia ; Sensitivity and Specificity ; Sex Factors ; Subclinical thyroid disorders ; surveys ; Thyroid Diseases - diagnosis ; Thyroid Diseases - epidemiology ; Thyroid Function Tests ; thyroid hormones ; thyrotropin ; thyroxine</subject><ispartof>Nutrition, metabolism, and cardiovascular diseases, 2015-12, Vol.25 (12), p.1104-1110</ispartof><rights>The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University</rights><rights>2015 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University</rights><rights>Copyright © 2015 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c621t-8c240698e5a889059cf2c93062f2f14b1c237ca4d37a567e2896cd50b91ffc663</citedby><cites>FETCH-LOGICAL-c621t-8c240698e5a889059cf2c93062f2f14b1c237ca4d37a567e2896cd50b91ffc663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0939475315300922$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26615224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Delitala, A.P</creatorcontrib><creatorcontrib>Filigheddu, F</creatorcontrib><creatorcontrib>Orrù, M</creatorcontrib><creatorcontrib>AlGhatrif, M</creatorcontrib><creatorcontrib>Steri, M</creatorcontrib><creatorcontrib>Pilia, M.G</creatorcontrib><creatorcontrib>Scuteri, A</creatorcontrib><creatorcontrib>Lobina, M</creatorcontrib><creatorcontrib>Piras, M.G</creatorcontrib><creatorcontrib>Delitala, G</creatorcontrib><creatorcontrib>Lakatta, E.G</creatorcontrib><creatorcontrib>Schlessinger, D</creatorcontrib><creatorcontrib>Cucca, F</creatorcontrib><title>No evidence of association between subclinical thyroid disorders and common carotid intima medial thickness or atherosclerotic plaque</title><title>Nutrition, metabolism, and cardiovascular diseases</title><addtitle>Nutr Metab Cardiovasc Dis</addtitle><description>Abstract Background and aims Increased carotid artery intima-media thickness (IMT) and the presence of plaques have been shown to be predictors of cardiovascular disease. The cardiovascular risk in patients with overt thyroid diseases is related to increased risk of atherosclerosis, but there has been no clear evidence about subclinical disorders. We have assessed whether subclinical thyroid dysfunction is associated with arterial thickening and plaque. Methods and results The SardiNIA study is a population-based survey on the Italian island of Sardinia. We reviewed data from 5815 subjects (aged 14–102 years), none of whom had overt hyperthyroidism or hypothyroidism or was taking thyroid medication. Serum thyrotropin (TSH), free thyroxine, together with carotid ultrasound IMT and the presence of common carotid plaques were analysed in all subjects. Possible association of IMT and carotid plaques with thyroid parameters was evaluated by univariate and multivariate analyses. IMT was significantly associated with age, sex, smoking, low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol, pulse pressure (PP), history of arterial hypertension, diabetes, and previous cardiovascular events (p = 0.001 or lower, R2 = 0.47). Carotid plaques were predicted by age, sex, LDL, PP, history of diabetes, previous cardiovascular events, and the use of statins (p = 0.029 or lower). Thyroid hormone was not predictive of carotid atherosclerosis when adjusted for confounders. Conclusion Thyroid hormone is not associated with increased IMT or with the presence of carotid artery plaque. Our data do not support the idea that treating subclinical disorders might help to prevent arterial remodelling or carotid atherosclerosis.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Arterial remodelling</subject><subject>Atherosclerosis</subject><subject>blood serum</subject><subject>Cardiovascular</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>carotid arteries</subject><subject>Carotid Artery Diseases - diagnostic imaging</subject><subject>Carotid Artery Diseases - epidemiology</subject><subject>Carotid Intima-Media Thickness</subject><subject>Carotid plaques</subject><subject>Carotid Stenosis - diagnostic imaging</subject><subject>Carotid Stenosis - epidemiology</subject><subject>Comorbidity</subject><subject>Confidence Intervals</subject><subject>Cross-Sectional Studies</subject><subject>diabetes</subject><subject>drug therapy</subject><subject>Female</subject><subject>high density lipoprotein cholesterol</subject><subject>Humans</subject><subject>hypertension</subject><subject>hyperthyroidism</subject><subject>Hyperthyroidism - diagnosis</subject><subject>Hyperthyroidism - epidemiology</subject><subject>hypothyroidism</subject><subject>Hypothyroidism - diagnosis</subject><subject>Hypothyroidism - epidemiology</subject><subject>Longitudinal Studies</subject><subject>low density lipoprotein cholesterol</subject><subject>Male</subject><subject>metabolism</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Odds Ratio</subject><subject>patients</subject><subject>risk</subject><subject>Risk Assessment</subject><subject>Sardinia</subject><subject>Sensitivity and Specificity</subject><subject>Sex Factors</subject><subject>Subclinical thyroid disorders</subject><subject>surveys</subject><subject>Thyroid Diseases - diagnosis</subject><subject>Thyroid Diseases - epidemiology</subject><subject>Thyroid Function Tests</subject><subject>thyroid hormones</subject><subject>thyrotropin</subject><subject>thyroxine</subject><issn>0939-4753</issn><issn>1590-3729</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksuO1DAQRSMEYpqBP0DISzYd_IoTb5DQaHhII1gAa8tdrtDuSezGThr1B_DfOPTM8NjMyou6t3yrTlXVc0ZrRpl6tavDPCK4mlPW1FTXlLIH1Yo1mq5Fy_XDakW10GvZNuKsepLzjlLRUiEfV2dcKdZwLlfVz4-R4ME7DIAk9sTmHMHbycdANjj9QAwkzxsYfPBgBzJtjyl6R5zPMTlMmdjgCMRxLAawKU6l6MPkR0tGdP63xcN1wJxJTMROW0wxw4CLFMh-sN9nfFo96u2Q8dnNe159fXv55eL9-urTuw8Xb67WoDib1h1wSZXusLFdp2mjoeegBVW85z2TGwZctGClE61tVIu80wpcQzea9T0oJc6r16e--3lT0gGGKdnB7FOJm44mWm_-rQS_Nd_iwUjVScllafDypkGKJXeezOgz4DDYgHHOhhc0Qksu-L1S1jZUcq20LlJ5kkJZTU7Y3yVi1Cywzc6cYJsFtqHaFNjF9uLvae5Mt3T_jItlpwePyWTwC2nnE8JkXPT3_fB_g9tDuMYj5l2cUyi8DDOZG2o-Lwe33BtrBKWac_EL47TVYw</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Delitala, A.P</creator><creator>Filigheddu, F</creator><creator>Orrù, M</creator><creator>AlGhatrif, M</creator><creator>Steri, M</creator><creator>Pilia, M.G</creator><creator>Scuteri, A</creator><creator>Lobina, M</creator><creator>Piras, M.G</creator><creator>Delitala, G</creator><creator>Lakatta, E.G</creator><creator>Schlessinger, D</creator><creator>Cucca, F</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20151201</creationdate><title>No evidence of association between subclinical thyroid disorders and common carotid intima medial thickness or atherosclerotic plaque</title><author>Delitala, A.P ; Filigheddu, F ; Orrù, M ; AlGhatrif, M ; Steri, M ; Pilia, M.G ; Scuteri, A ; Lobina, M ; Piras, M.G ; Delitala, G ; Lakatta, E.G ; Schlessinger, D ; Cucca, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c621t-8c240698e5a889059cf2c93062f2f14b1c237ca4d37a567e2896cd50b91ffc663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Arterial remodelling</topic><topic>Atherosclerosis</topic><topic>blood serum</topic><topic>Cardiovascular</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>carotid arteries</topic><topic>Carotid Artery Diseases - diagnostic imaging</topic><topic>Carotid Artery Diseases - epidemiology</topic><topic>Carotid Intima-Media Thickness</topic><topic>Carotid plaques</topic><topic>Carotid Stenosis - diagnostic imaging</topic><topic>Carotid Stenosis - epidemiology</topic><topic>Comorbidity</topic><topic>Confidence Intervals</topic><topic>Cross-Sectional Studies</topic><topic>diabetes</topic><topic>drug therapy</topic><topic>Female</topic><topic>high density lipoprotein cholesterol</topic><topic>Humans</topic><topic>hypertension</topic><topic>hyperthyroidism</topic><topic>Hyperthyroidism - diagnosis</topic><topic>Hyperthyroidism - epidemiology</topic><topic>hypothyroidism</topic><topic>Hypothyroidism - diagnosis</topic><topic>Hypothyroidism - epidemiology</topic><topic>Longitudinal Studies</topic><topic>low density lipoprotein cholesterol</topic><topic>Male</topic><topic>metabolism</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Odds Ratio</topic><topic>patients</topic><topic>risk</topic><topic>Risk Assessment</topic><topic>Sardinia</topic><topic>Sensitivity and Specificity</topic><topic>Sex Factors</topic><topic>Subclinical thyroid disorders</topic><topic>surveys</topic><topic>Thyroid Diseases - diagnosis</topic><topic>Thyroid Diseases - epidemiology</topic><topic>Thyroid Function Tests</topic><topic>thyroid hormones</topic><topic>thyrotropin</topic><topic>thyroxine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Delitala, A.P</creatorcontrib><creatorcontrib>Filigheddu, F</creatorcontrib><creatorcontrib>Orrù, M</creatorcontrib><creatorcontrib>AlGhatrif, M</creatorcontrib><creatorcontrib>Steri, M</creatorcontrib><creatorcontrib>Pilia, M.G</creatorcontrib><creatorcontrib>Scuteri, A</creatorcontrib><creatorcontrib>Lobina, M</creatorcontrib><creatorcontrib>Piras, M.G</creatorcontrib><creatorcontrib>Delitala, G</creatorcontrib><creatorcontrib>Lakatta, E.G</creatorcontrib><creatorcontrib>Schlessinger, D</creatorcontrib><creatorcontrib>Cucca, F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Delitala, A.P</au><au>Filigheddu, F</au><au>Orrù, M</au><au>AlGhatrif, M</au><au>Steri, M</au><au>Pilia, M.G</au><au>Scuteri, A</au><au>Lobina, M</au><au>Piras, M.G</au><au>Delitala, G</au><au>Lakatta, E.G</au><au>Schlessinger, D</au><au>Cucca, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>No evidence of association between subclinical thyroid disorders and common carotid intima medial thickness or atherosclerotic plaque</atitle><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle><addtitle>Nutr Metab Cardiovasc Dis</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>25</volume><issue>12</issue><spage>1104</spage><epage>1110</epage><pages>1104-1110</pages><issn>0939-4753</issn><eissn>1590-3729</eissn><abstract>Abstract Background and aims Increased carotid artery intima-media thickness (IMT) and the presence of plaques have been shown to be predictors of cardiovascular disease. The cardiovascular risk in patients with overt thyroid diseases is related to increased risk of atherosclerosis, but there has been no clear evidence about subclinical disorders. We have assessed whether subclinical thyroid dysfunction is associated with arterial thickening and plaque. Methods and results The SardiNIA study is a population-based survey on the Italian island of Sardinia. We reviewed data from 5815 subjects (aged 14–102 years), none of whom had overt hyperthyroidism or hypothyroidism or was taking thyroid medication. Serum thyrotropin (TSH), free thyroxine, together with carotid ultrasound IMT and the presence of common carotid plaques were analysed in all subjects. Possible association of IMT and carotid plaques with thyroid parameters was evaluated by univariate and multivariate analyses. IMT was significantly associated with age, sex, smoking, low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol, pulse pressure (PP), history of arterial hypertension, diabetes, and previous cardiovascular events (p = 0.001 or lower, R2 = 0.47). Carotid plaques were predicted by age, sex, LDL, PP, history of diabetes, previous cardiovascular events, and the use of statins (p = 0.029 or lower). Thyroid hormone was not predictive of carotid atherosclerosis when adjusted for confounders. Conclusion Thyroid hormone is not associated with increased IMT or with the presence of carotid artery plaque. Our data do not support the idea that treating subclinical disorders might help to prevent arterial remodelling or carotid atherosclerosis.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26615224</pmid><doi>10.1016/j.numecd.2015.09.001</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nutrition, metabolism, and cardiovascular diseases, 2015-12, Vol.25 (12), p.1104-1110 |
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| subjects | Adult Age Factors Aged Analysis of Variance Arterial remodelling Atherosclerosis blood serum Cardiovascular Cardiovascular Diseases - diagnosis Cardiovascular Diseases - epidemiology carotid arteries Carotid Artery Diseases - diagnostic imaging Carotid Artery Diseases - epidemiology Carotid Intima-Media Thickness Carotid plaques Carotid Stenosis - diagnostic imaging Carotid Stenosis - epidemiology Comorbidity Confidence Intervals Cross-Sectional Studies diabetes drug therapy Female high density lipoprotein cholesterol Humans hypertension hyperthyroidism Hyperthyroidism - diagnosis Hyperthyroidism - epidemiology hypothyroidism Hypothyroidism - diagnosis Hypothyroidism - epidemiology Longitudinal Studies low density lipoprotein cholesterol Male metabolism Middle Aged Multivariate Analysis Odds Ratio patients risk Risk Assessment Sardinia Sensitivity and Specificity Sex Factors Subclinical thyroid disorders surveys Thyroid Diseases - diagnosis Thyroid Diseases - epidemiology Thyroid Function Tests thyroid hormones thyrotropin thyroxine |
| title | No evidence of association between subclinical thyroid disorders and common carotid intima medial thickness or atherosclerotic plaque |
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