Increased norovirus activity was associated with a novel norovirus GII.17 variant in Beijing, China during winter 2014-2015
Norovirus (NoV) is a leading cause of sporadic cases and outbreaks of acute gastroenteritis (AGE). Increased NoV activity was observed in Beijing, China during winter 2014-2015; therefore, we examined the epidemiological patterns and genetic characteristics of NoV in the sporadic cases and outbreaks...
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| Veröffentlicht in: | BMC infectious diseases 2015-12, Vol.15 (573), p.574, Article 574 |
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| creator | Gao, Zhiyong Liu, Baiwei Huo, Da Yan, Hanqiu Jia, Lei Du, Yiwei Qian, Haikun Yang, Yang Wang, Xiaoli Li, Jie Wang, Quanyi |
| description | Norovirus (NoV) is a leading cause of sporadic cases and outbreaks of acute gastroenteritis (AGE). Increased NoV activity was observed in Beijing, China during winter 2014-2015; therefore, we examined the epidemiological patterns and genetic characteristics of NoV in the sporadic cases and outbreaks.
The weekly number of infectious diarrhea cases reported by all hospitals in Beijing was analyzed through the China information system for disease control and prevention. Fecal specimens were collected from the outbreaks and outpatients with AGE, and GI and GII NoVs were detected using real time reverse transcription polymerase chain reaction. The partial capsid genes and RNA-dependent RNA polymerase (RdRp) genes of NoV were both amplified and sequenced, and genotyping and phylogenetic analyses were performed.
Between December 2014 and March 2015, the number of infectious diarrhea cases in Beijing (10,626 cases) increased by 35.6% over that of the previous year (7835 cases), and the detection rate of NoV (29.8%, 191/640) among outpatients with AGE was significantly higher than in the previous year (12.9%, 79/613) (χ(2) = 53.252, P |
| doi_str_mv | 10.1186/s12879-015-1315-z |
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The weekly number of infectious diarrhea cases reported by all hospitals in Beijing was analyzed through the China information system for disease control and prevention. Fecal specimens were collected from the outbreaks and outpatients with AGE, and GI and GII NoVs were detected using real time reverse transcription polymerase chain reaction. The partial capsid genes and RNA-dependent RNA polymerase (RdRp) genes of NoV were both amplified and sequenced, and genotyping and phylogenetic analyses were performed.
Between December 2014 and March 2015, the number of infectious diarrhea cases in Beijing (10,626 cases) increased by 35.6% over that of the previous year (7835 cases), and the detection rate of NoV (29.8%, 191/640) among outpatients with AGE was significantly higher than in the previous year (12.9%, 79/613) (χ(2) = 53.252, P < 0.001). Between November 2014 and March 2015, 35 outbreaks of AGE were reported in Beijing, and NoVs were detected in 33 outbreaks, all of which belonged to the GII genogroup. NoVs were sequenced and genotyped in 22 outbreaks, among which 20 were caused by a novel GII.17 strain. Among outpatients with AGE, this novel GII.17 strain was first detected in an outpatient in August 2014, and it replaced GII.4 Sydney_2012 as the predominant variant between December 2014 and March 2015. A phylogenetic analysis of the capsid genes and RdRp genes revealed that this novel GII.17 strain was distinct from previously identified GII variants, and it was recently designated as GII.P17_GII.17. This variant was further clustered into two sub-groups, named GII.17_2012 and GII.17_2014. During winter 2014-2015, GII.17_2014 caused the majority of AGE outbreaks in China and Japan.
During winter 2014-2015, a novel NoV GII.17 variant replaced the GII.4 variant Sydney 2012 as the predominant strain in Beijing, China and caused increased NoV activity.</description><identifier>ISSN: 1471-2334</identifier><identifier>EISSN: 1471-2334</identifier><identifier>DOI: 10.1186/s12879-015-1315-z</identifier><identifier>PMID: 26678989</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Analysis ; Beijing - epidemiology ; Caliciviridae Infections - epidemiology ; Caliciviridae Infections - virology ; Capsid Proteins - genetics ; Care and treatment ; Cladistic analysis ; Complications and side effects ; Diarrhea - epidemiology ; Diarrhea - virology ; Disease Outbreaks ; Gastroenteritis ; Gastroenteritis - epidemiology ; Gastroenteritis - virology ; Genetic transcription ; Hospitals ; Humans ; Infectious diseases ; Norovirus ; Norovirus - genetics ; Norovirus - pathogenicity ; Outpatients ; Phylogeny ; Physiological aspects ; Real-Time Polymerase Chain Reaction ; Seasons</subject><ispartof>BMC infectious diseases, 2015-12, Vol.15 (573), p.574, Article 574</ispartof><rights>COPYRIGHT 2015 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2015</rights><rights>Gao et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c562t-75333466c77e354f24bea64b2e6afbbecdf4f166e1d44741c3405ab2fcc75cce3</citedby><cites>FETCH-LOGICAL-c562t-75333466c77e354f24bea64b2e6afbbecdf4f166e1d44741c3405ab2fcc75cce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683961/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683961/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,27926,27927,53793,53795</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26678989$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Zhiyong</creatorcontrib><creatorcontrib>Liu, Baiwei</creatorcontrib><creatorcontrib>Huo, Da</creatorcontrib><creatorcontrib>Yan, Hanqiu</creatorcontrib><creatorcontrib>Jia, Lei</creatorcontrib><creatorcontrib>Du, Yiwei</creatorcontrib><creatorcontrib>Qian, Haikun</creatorcontrib><creatorcontrib>Yang, Yang</creatorcontrib><creatorcontrib>Wang, Xiaoli</creatorcontrib><creatorcontrib>Li, Jie</creatorcontrib><creatorcontrib>Wang, Quanyi</creatorcontrib><title>Increased norovirus activity was associated with a novel norovirus GII.17 variant in Beijing, China during winter 2014-2015</title><title>BMC infectious diseases</title><addtitle>BMC Infect Dis</addtitle><description>Norovirus (NoV) is a leading cause of sporadic cases and outbreaks of acute gastroenteritis (AGE). Increased NoV activity was observed in Beijing, China during winter 2014-2015; therefore, we examined the epidemiological patterns and genetic characteristics of NoV in the sporadic cases and outbreaks.
The weekly number of infectious diarrhea cases reported by all hospitals in Beijing was analyzed through the China information system for disease control and prevention. Fecal specimens were collected from the outbreaks and outpatients with AGE, and GI and GII NoVs were detected using real time reverse transcription polymerase chain reaction. The partial capsid genes and RNA-dependent RNA polymerase (RdRp) genes of NoV were both amplified and sequenced, and genotyping and phylogenetic analyses were performed.
Between December 2014 and March 2015, the number of infectious diarrhea cases in Beijing (10,626 cases) increased by 35.6% over that of the previous year (7835 cases), and the detection rate of NoV (29.8%, 191/640) among outpatients with AGE was significantly higher than in the previous year (12.9%, 79/613) (χ(2) = 53.252, P < 0.001). Between November 2014 and March 2015, 35 outbreaks of AGE were reported in Beijing, and NoVs were detected in 33 outbreaks, all of which belonged to the GII genogroup. NoVs were sequenced and genotyped in 22 outbreaks, among which 20 were caused by a novel GII.17 strain. Among outpatients with AGE, this novel GII.17 strain was first detected in an outpatient in August 2014, and it replaced GII.4 Sydney_2012 as the predominant variant between December 2014 and March 2015. A phylogenetic analysis of the capsid genes and RdRp genes revealed that this novel GII.17 strain was distinct from previously identified GII variants, and it was recently designated as GII.P17_GII.17. This variant was further clustered into two sub-groups, named GII.17_2012 and GII.17_2014. During winter 2014-2015, GII.17_2014 caused the majority of AGE outbreaks in China and Japan.
During winter 2014-2015, a novel NoV GII.17 variant replaced the GII.4 variant Sydney 2012 as the predominant strain in Beijing, China and caused increased NoV activity.</description><subject>Analysis</subject><subject>Beijing - epidemiology</subject><subject>Caliciviridae Infections - epidemiology</subject><subject>Caliciviridae Infections - virology</subject><subject>Capsid Proteins - genetics</subject><subject>Care and treatment</subject><subject>Cladistic analysis</subject><subject>Complications and side effects</subject><subject>Diarrhea - epidemiology</subject><subject>Diarrhea - virology</subject><subject>Disease Outbreaks</subject><subject>Gastroenteritis</subject><subject>Gastroenteritis - epidemiology</subject><subject>Gastroenteritis - virology</subject><subject>Genetic transcription</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Norovirus</subject><subject>Norovirus - genetics</subject><subject>Norovirus - pathogenicity</subject><subject>Outpatients</subject><subject>Phylogeny</subject><subject>Physiological aspects</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Seasons</subject><issn>1471-2334</issn><issn>1471-2334</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqNkl1rFDEUhgdRbK3-AG8k4JXgrHMy-Zi5EdpF60Ch4NdtyGTO7GbZTWqS2dr6503ZWnfBCwmc5CTPe8hJ3qJ4CdUMoBHvItBGtmUFvIQ6h9tHxTEwCSWta_Z4b31UPItxVVUgG9o-LY6oELJpm_a4-NU5E1BHHIjzwW9tmCLRJtmtTTfkWuckRm-sTpm4tmlJdAa3uN7Dz7tuBpJsdbDaJWIdOUO7sm7xlsyX1mkyTCFnWe4SBkIrYGUO_HnxZNTriC_u55Pi28cPX-efyovL825-elEaLmgqJa9zC0IYKbHmbKSsRy1YT1Hose_RDCMbQQiEgTHJwNSs4rqnozGSG4P1SfF-V_dq6jc4GHQp6LW6Cnajw43y2qrDE2eXauG3iommbgXkAq_vCwT_Y8KY1MpPweU7K5Cy5ZxTKf9SC71GZd3oczGzsdGoU8ZByNx3m6nZP6g8BtxY4x2ONu8fCN4cCDKT8Gda6ClG1X35_P_s5fdDFnasCT7GgOPDg0Cl7uyldvZS-afUnb3Ubda82n_JB8UfP9W_AYzayVQ</recordid><startdate>20151218</startdate><enddate>20151218</enddate><creator>Gao, Zhiyong</creator><creator>Liu, Baiwei</creator><creator>Huo, Da</creator><creator>Yan, Hanqiu</creator><creator>Jia, Lei</creator><creator>Du, Yiwei</creator><creator>Qian, Haikun</creator><creator>Yang, Yang</creator><creator>Wang, Xiaoli</creator><creator>Li, Jie</creator><creator>Wang, Quanyi</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7T2</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>5PM</scope></search><sort><creationdate>20151218</creationdate><title>Increased norovirus activity was associated with a novel norovirus GII.17 variant in Beijing, China during winter 2014-2015</title><author>Gao, Zhiyong ; Liu, Baiwei ; Huo, Da ; Yan, Hanqiu ; Jia, Lei ; Du, Yiwei ; Qian, Haikun ; Yang, Yang ; Wang, Xiaoli ; Li, Jie ; Wang, Quanyi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c562t-75333466c77e354f24bea64b2e6afbbecdf4f166e1d44741c3405ab2fcc75cce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Analysis</topic><topic>Beijing - epidemiology</topic><topic>Caliciviridae Infections - epidemiology</topic><topic>Caliciviridae Infections - virology</topic><topic>Capsid Proteins - genetics</topic><topic>Care and treatment</topic><topic>Cladistic analysis</topic><topic>Complications and side effects</topic><topic>Diarrhea - epidemiology</topic><topic>Diarrhea - virology</topic><topic>Disease Outbreaks</topic><topic>Gastroenteritis</topic><topic>Gastroenteritis - epidemiology</topic><topic>Gastroenteritis - virology</topic><topic>Genetic transcription</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Norovirus</topic><topic>Norovirus - genetics</topic><topic>Norovirus - pathogenicity</topic><topic>Outpatients</topic><topic>Phylogeny</topic><topic>Physiological aspects</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Seasons</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gao, Zhiyong</creatorcontrib><creatorcontrib>Liu, Baiwei</creatorcontrib><creatorcontrib>Huo, Da</creatorcontrib><creatorcontrib>Yan, Hanqiu</creatorcontrib><creatorcontrib>Jia, Lei</creatorcontrib><creatorcontrib>Du, Yiwei</creatorcontrib><creatorcontrib>Qian, Haikun</creatorcontrib><creatorcontrib>Yang, Yang</creatorcontrib><creatorcontrib>Wang, Xiaoli</creatorcontrib><creatorcontrib>Li, Jie</creatorcontrib><creatorcontrib>Wang, Quanyi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale_Opposing Viewpoints In Context</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Zhiyong</au><au>Liu, Baiwei</au><au>Huo, Da</au><au>Yan, Hanqiu</au><au>Jia, Lei</au><au>Du, Yiwei</au><au>Qian, Haikun</au><au>Yang, Yang</au><au>Wang, Xiaoli</au><au>Li, Jie</au><au>Wang, Quanyi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased norovirus activity was associated with a novel norovirus GII.17 variant in Beijing, China during winter 2014-2015</atitle><jtitle>BMC infectious diseases</jtitle><addtitle>BMC Infect Dis</addtitle><date>2015-12-18</date><risdate>2015</risdate><volume>15</volume><issue>573</issue><spage>574</spage><pages>574-</pages><artnum>574</artnum><issn>1471-2334</issn><eissn>1471-2334</eissn><abstract>Norovirus (NoV) is a leading cause of sporadic cases and outbreaks of acute gastroenteritis (AGE). Increased NoV activity was observed in Beijing, China during winter 2014-2015; therefore, we examined the epidemiological patterns and genetic characteristics of NoV in the sporadic cases and outbreaks.
The weekly number of infectious diarrhea cases reported by all hospitals in Beijing was analyzed through the China information system for disease control and prevention. Fecal specimens were collected from the outbreaks and outpatients with AGE, and GI and GII NoVs were detected using real time reverse transcription polymerase chain reaction. The partial capsid genes and RNA-dependent RNA polymerase (RdRp) genes of NoV were both amplified and sequenced, and genotyping and phylogenetic analyses were performed.
Between December 2014 and March 2015, the number of infectious diarrhea cases in Beijing (10,626 cases) increased by 35.6% over that of the previous year (7835 cases), and the detection rate of NoV (29.8%, 191/640) among outpatients with AGE was significantly higher than in the previous year (12.9%, 79/613) (χ(2) = 53.252, P < 0.001). Between November 2014 and March 2015, 35 outbreaks of AGE were reported in Beijing, and NoVs were detected in 33 outbreaks, all of which belonged to the GII genogroup. NoVs were sequenced and genotyped in 22 outbreaks, among which 20 were caused by a novel GII.17 strain. Among outpatients with AGE, this novel GII.17 strain was first detected in an outpatient in August 2014, and it replaced GII.4 Sydney_2012 as the predominant variant between December 2014 and March 2015. A phylogenetic analysis of the capsid genes and RdRp genes revealed that this novel GII.17 strain was distinct from previously identified GII variants, and it was recently designated as GII.P17_GII.17. This variant was further clustered into two sub-groups, named GII.17_2012 and GII.17_2014. During winter 2014-2015, GII.17_2014 caused the majority of AGE outbreaks in China and Japan.
During winter 2014-2015, a novel NoV GII.17 variant replaced the GII.4 variant Sydney 2012 as the predominant strain in Beijing, China and caused increased NoV activity.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>26678989</pmid><doi>10.1186/s12879-015-1315-z</doi><oa>free_for_read</oa></addata></record> |
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| source | SpringerOpen; MEDLINE; SpringerNature Journals; PubMed Central Open Access; PubMed; DOAJ Directory of Open Access Journals; EZB Electronic Journals Library |
| subjects | Analysis Beijing - epidemiology Caliciviridae Infections - epidemiology Caliciviridae Infections - virology Capsid Proteins - genetics Care and treatment Cladistic analysis Complications and side effects Diarrhea - epidemiology Diarrhea - virology Disease Outbreaks Gastroenteritis Gastroenteritis - epidemiology Gastroenteritis - virology Genetic transcription Hospitals Humans Infectious diseases Norovirus Norovirus - genetics Norovirus - pathogenicity Outpatients Phylogeny Physiological aspects Real-Time Polymerase Chain Reaction Seasons |
| title | Increased norovirus activity was associated with a novel norovirus GII.17 variant in Beijing, China during winter 2014-2015 |
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