Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells
Vitamin B2 (riboflavin) is essential for metabolic functions and is synthesized by many bacteria, yeast, and plants, but not by mammals and other animals, which must acquire it from the diet. In mammals, modified pyrimidine intermediates from the microbial biosynthesis of riboflavin are recognized a...
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| Veröffentlicht in: | The Journal of biological chemistry 2015-12, Vol.290 (51), p.30204-30211 |
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| container_title | The Journal of biological chemistry |
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| creator | Eckle, Sidonia B.G. Corbett, Alexandra J. Keller, Andrew N. Chen, Zhenjun Godfrey, Dale I. Liu, Ligong Mak, Jeffrey Y.W. Fairlie, David P. Rossjohn, Jamie McCluskey, James |
| description | Vitamin B2 (riboflavin) is essential for metabolic functions and is synthesized by many bacteria, yeast, and plants, but not by mammals and other animals, which must acquire it from the diet. In mammals, modified pyrimidine intermediates from the microbial biosynthesis of riboflavin are recognized as signature biomarkers of microbial infection. This recognition occurs by specialized lymphocytes known as mucosal associated invariant T (MAIT) cells. The major histocompatibility class I-like antigen-presenting molecule, MR1, captures these pyrimidine intermediates, but only after their condensation with small molecules derived from glycolysis and other metabolic pathways to form short-lived antigens. The resulting MR1-Ag complexes are recognized by MAIT cell antigen receptors (αβ T cell receptors (TCRs)), and the subsequent MAIT cell immune responses are thought to protect the host from pathogens at mucosal surfaces. Here, we review our understanding of how these novel antigens are generated and discuss their interactions with MR1 and MAIT TCRs. |
| doi_str_mv | 10.1074/jbc.R115.685990 |
| format | Article |
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In mammals, modified pyrimidine intermediates from the microbial biosynthesis of riboflavin are recognized as signature biomarkers of microbial infection. This recognition occurs by specialized lymphocytes known as mucosal associated invariant T (MAIT) cells. The major histocompatibility class I-like antigen-presenting molecule, MR1, captures these pyrimidine intermediates, but only after their condensation with small molecules derived from glycolysis and other metabolic pathways to form short-lived antigens. The resulting MR1-Ag complexes are recognized by MAIT cell antigen receptors (αβ T cell receptors (TCRs)), and the subsequent MAIT cell immune responses are thought to protect the host from pathogens at mucosal surfaces. Here, we review our understanding of how these novel antigens are generated and discuss their interactions with MR1 and MAIT TCRs.</description><identifier>ISSN: 0021-9258</identifier><identifier>EISSN: 1083-351X</identifier><identifier>DOI: 10.1074/jbc.R115.685990</identifier><identifier>PMID: 26468291</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Ag presentation ; Animals ; Antigens, Bacterial - immunology ; Bacteria - immunology ; Bacterial Infections - immunology ; bacterial metabolism ; folate ; Histocompatibility Antigens Class I - immunology ; Humans ; Immunity, Mucosal ; innate immunity ; MAIT cells ; Minireviews ; MR1 ; Mucous Membrane - immunology ; Receptors, Antigen, T-Cell, alpha-beta - immunology ; riboflavin ; Riboflavin - immunology ; T cell recognition ; T-Lymphocytes - immunology ; vitamin</subject><ispartof>The Journal of biological chemistry, 2015-12, Vol.290 (51), p.30204-30211</ispartof><rights>2015 © 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.</rights><rights>2015 by The American Society for Biochemistry and Molecular Biology, Inc.</rights><rights>2015 by The American Society for Biochemistry and Molecular Biology, Inc. 2015 The American Society for Biochemistry and Molecular Biology, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-de8870f37a8c65a11276ceab95f81af19c331c6f9f2b4d8cf997b04b9973a7793</citedby><cites>FETCH-LOGICAL-c489t-de8870f37a8c65a11276ceab95f81af19c331c6f9f2b4d8cf997b04b9973a7793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683245/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683245/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26468291$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eckle, Sidonia B.G.</creatorcontrib><creatorcontrib>Corbett, Alexandra J.</creatorcontrib><creatorcontrib>Keller, Andrew N.</creatorcontrib><creatorcontrib>Chen, Zhenjun</creatorcontrib><creatorcontrib>Godfrey, Dale I.</creatorcontrib><creatorcontrib>Liu, Ligong</creatorcontrib><creatorcontrib>Mak, Jeffrey Y.W.</creatorcontrib><creatorcontrib>Fairlie, David P.</creatorcontrib><creatorcontrib>Rossjohn, Jamie</creatorcontrib><creatorcontrib>McCluskey, James</creatorcontrib><title>Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells</title><title>The Journal of biological chemistry</title><addtitle>J Biol Chem</addtitle><description>Vitamin B2 (riboflavin) is essential for metabolic functions and is synthesized by many bacteria, yeast, and plants, but not by mammals and other animals, which must acquire it from the diet. In mammals, modified pyrimidine intermediates from the microbial biosynthesis of riboflavin are recognized as signature biomarkers of microbial infection. This recognition occurs by specialized lymphocytes known as mucosal associated invariant T (MAIT) cells. The major histocompatibility class I-like antigen-presenting molecule, MR1, captures these pyrimidine intermediates, but only after their condensation with small molecules derived from glycolysis and other metabolic pathways to form short-lived antigens. The resulting MR1-Ag complexes are recognized by MAIT cell antigen receptors (αβ T cell receptors (TCRs)), and the subsequent MAIT cell immune responses are thought to protect the host from pathogens at mucosal surfaces. Here, we review our understanding of how these novel antigens are generated and discuss their interactions with MR1 and MAIT TCRs.</description><subject>Ag presentation</subject><subject>Animals</subject><subject>Antigens, Bacterial - immunology</subject><subject>Bacteria - immunology</subject><subject>Bacterial Infections - immunology</subject><subject>bacterial metabolism</subject><subject>folate</subject><subject>Histocompatibility Antigens Class I - immunology</subject><subject>Humans</subject><subject>Immunity, Mucosal</subject><subject>innate immunity</subject><subject>MAIT cells</subject><subject>Minireviews</subject><subject>MR1</subject><subject>Mucous Membrane - immunology</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - immunology</subject><subject>riboflavin</subject><subject>Riboflavin - immunology</subject><subject>T cell recognition</subject><subject>T-Lymphocytes - immunology</subject><subject>vitamin</subject><issn>0021-9258</issn><issn>1083-351X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9PHCEUx4lpo-uPs7eGYy-zwsDMwKWJbrSaaGqMmqYXwrwBi5mFFZhN9r8vZq2ph3J5Bz58ee99EDqmZE5Jx0-ee5jfUdrMW9FISXbQjBLBKtbQn5_QjJCaVrJuxB7aT-mZlMMl3UV7dctbUUs6Q7_uDIQn77ILHgeLH13WS-fxGb6NBqaYQkxY-wGfbVYxDBPkhPsNvpkgJD3i05QCOJ3NgK_8Wkenfcb3eGHGMR2iz1aPyRy91QP0cHF-v7isrn98v1qcXlfAhczVYIToiGWdFtA2mtK6a8HoXjZWUG2pBMYotFbauueDACtl1xPel8J010l2gL5tc1dTvzQDGJ-jHtUquqWOGxW0Ux9vvPutnsJalR2wmjcl4OtbQAwvk0lZLV2CMoL2JkxJ0a4hnFMm2oKebFGIIaVo7Ps3lKhXI6oYUa9G1NZIefHl3-7e-b8KCiC3gCk7WjsTVQJnPJjBFQNZDcH9N_wPk9qcPw</recordid><startdate>20151218</startdate><enddate>20151218</enddate><creator>Eckle, Sidonia B.G.</creator><creator>Corbett, Alexandra J.</creator><creator>Keller, Andrew N.</creator><creator>Chen, Zhenjun</creator><creator>Godfrey, Dale I.</creator><creator>Liu, Ligong</creator><creator>Mak, Jeffrey Y.W.</creator><creator>Fairlie, David P.</creator><creator>Rossjohn, Jamie</creator><creator>McCluskey, James</creator><general>Elsevier Inc</general><general>American Society for Biochemistry and Molecular Biology</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20151218</creationdate><title>Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells</title><author>Eckle, Sidonia B.G. ; 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In mammals, modified pyrimidine intermediates from the microbial biosynthesis of riboflavin are recognized as signature biomarkers of microbial infection. This recognition occurs by specialized lymphocytes known as mucosal associated invariant T (MAIT) cells. The major histocompatibility class I-like antigen-presenting molecule, MR1, captures these pyrimidine intermediates, but only after their condensation with small molecules derived from glycolysis and other metabolic pathways to form short-lived antigens. The resulting MR1-Ag complexes are recognized by MAIT cell antigen receptors (αβ T cell receptors (TCRs)), and the subsequent MAIT cell immune responses are thought to protect the host from pathogens at mucosal surfaces. 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| subjects | Ag presentation Animals Antigens, Bacterial - immunology Bacteria - immunology Bacterial Infections - immunology bacterial metabolism folate Histocompatibility Antigens Class I - immunology Humans Immunity, Mucosal innate immunity MAIT cells Minireviews MR1 Mucous Membrane - immunology Receptors, Antigen, T-Cell, alpha-beta - immunology riboflavin Riboflavin - immunology T cell recognition T-Lymphocytes - immunology vitamin |
| title | Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells |
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