Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-a...

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Veröffentlicht in:	Nature communications 2015-12, Vol.6 (1), p.10166-10166, Article 10166
Hauptverfasser:	Jiang, Changtao, Xie, Cen, Lv, Ying, Li, Jing, Krausz, Kristopher W., Shi, Jingmin, Brocker, Chad N., Desai, Dhimant, Amin, Shantu G., Bisson, William H., Liu, Yulan, Gavrilova, Oksana, Patterson, Andrew D., Gonzalez, Frank J.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/109 38/77 38/90 631/443/319/1642/393 631/80/86 64/60 692/700/565 82/58 82/6 Acids Adolescent Adult Aged Animals Bile Biopsy Body mass index Ceramides - biosynthesis Cholic Acids - pharmacology Diabetes Diet, High-Fat Fatty Liver - metabolism Female Gastrointestinal surgery Genes Glycine - pharmacology Humanities and Social Sciences Humans Ileum - metabolism Insulin resistance Insulin Resistance - genetics Intestinal Mucosa - metabolism Isoxazoles - pharmacology Liver - drug effects Liver - metabolism Liver - pathology Male Metabolic disorders Mice Microbiota Middle Aged multidisciplinary Obesity Obesity - metabolism Oral administration Receptors, Cytoplasmic and Nuclear - agonists Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Science Science (multidisciplinary) Small intestine Toxicology Young Adult
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