Translational Regulation of the Mitochondrial Genome Following Redistribution of Mitochondrial MicroRNA in the Diabetic Heart

BACKGROUND—Cardiomyocytes are rich in mitochondria which are situated in spatially distinct subcellular regions, including those under the plasma membrane, subsarcolemmal mitochondria, and those between the myofibrils, interfibrillar mitochondria. We previously observed subpopulation-specific differ...

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Veröffentlicht in:	Circulation. Cardiovascular genetics 2015-12, Vol.8 (6), p.785-802
Hauptverfasser:	Jagannathan, Rajaganapathi, Thapa, Dharendra, Nichols, Cody E, Shepherd, Danielle L, Stricker, Janelle C, Croston, Tara L, Baseler, Walter A, Lewis, Sara E, Martinez, Ivan, Hollander, John M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetic Cardiomyopathies - metabolism Diabetic Cardiomyopathies - pathology Genome, Mitochondrial Mice MicroRNAs - metabolism Mitochondria, Heart - metabolism Mitochondria, Heart - pathology Mitochondrial Proteins Protein Biosynthesis RNA - metabolism
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