Evaluation of a Live-Attenuated Human Parainfluenza Type 1 Vaccine in Adults and Children
We conducted a phase I clinical trial (clinicaltrials.gov identifier, NCT00641017) of the experimental live-attenuated human parainfluenza virus type 1 (HPIV-1) vaccine rHPIV-1/84/del 170/942A sequentially in 3 groups: adults, HPIV-1–seropositive children, and HPIV-1–seronegative children, the targe...
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| Veröffentlicht in: | Journal of the Pediatric Infectious Diseases Society 2015-12, Vol.4 (4), p.e143-e146 |
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| container_title | Journal of the Pediatric Infectious Diseases Society |
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| creator | Karron, Ruth A. San Mateo, Jocelyn Thumar, Bhagvanji Schaap-Nutt, Anne Buchholz, Ursula J. Schmidt, Alexander C. Bartlett, Emmalene J. Murphy, Brian R. Collins, Peter L. |
| description | We conducted a phase I clinical trial (clinicaltrials.gov identifier, NCT00641017) of the experimental live-attenuated human parainfluenza virus type 1 (HPIV-1) vaccine rHPIV-1/84/del 170/942A sequentially in 3 groups: adults, HPIV-1–seropositive children, and HPIV-1–seronegative children, the target population for vaccination. rHPIV-1/84/del 170/942A was appropriately restricted in replication in adults and HPIV-1–seropositive children but was overattenuated (ie, insufficiently infectious and immunogenic) for HPIV-1–seronegative children. |
| doi_str_mv | 10.1093/jpids/piu104 |
| format | Article |
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Published by Oxford University Press on behalf of the Pediatric Infectious Diseases Society. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. 2014</rights><rights>The Author 2014. Published by Oxford University Press on behalf of the Pediatric Infectious Diseases Society. All rights reserved. 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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adult Antibodies, Viral - blood Child, Preschool Double-Blind Method ELECTRONIC ARTICLES Humans Infant Parainfluenza Vaccines - therapeutic use Parainfluenza Virus 1, Human Paramyxoviridae Infections - epidemiology Paramyxoviridae Infections - prevention & control Vaccines, Attenuated - therapeutic use |
| title | Evaluation of a Live-Attenuated Human Parainfluenza Type 1 Vaccine in Adults and Children |
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