A subset of AID-dependent B-1a cells initiates hypersensitivity and pneumococcal pneumonia resistance

We propose that there is a special B‐1a B cell subset (“sB‐1a” cells) that mediates linked processes very early after immunization to initiate cutaneous contact sensitivity (CS), delayed‐type hypersensitivity (DTH), and immune resistance to pneumococcal pneumonia. Our published data indicate that in...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2015-12, Vol.1362 (1), p.200-214
Hauptverfasser:	Askenase, Phillip W., Bryniarski, Krzysztof, Paliwal, Vipin, Redegeld, Frank, Groot Kormelink, Thomas, Kerfoot, Steven, Hutchinson, Andrew T., van Loveren, Henk, Campos, Regis, Itakura, Atsuko, Majewska-Szczepanik, Monika, Yamamoto, Natsuo, Nazimek, Katarzyn, Szczepanik, Marian, Ptak, Wold
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation activation-induced deaminase Affinity AID Animals Antimony B cell B-Lymphocyte Subsets - immunology B-Lymphocyte Subsets - metabolism contact sensitivity CS delayed‐type hypersensitivity Cytidine Deaminase - deficiency Cytidine Deaminase - immunology delayed-type hypersensitivity Dermatitis, Contact - immunology Dermatitis, Contact - metabolism DTH FLC free antibody light chains free antibody light chains FLC Humans Hypersensitivity Immunization Immunoglobulins interleukin 4 Mast Cells - immunology Mast Cells - metabolism Mice pneumococcal pneumonia Pneumonia Pneumonia, Pneumococcal - immunology Pneumonia, Pneumococcal - prevention & control Silver Streptococcus pneumoniae
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