Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

ObjectiveThe colonic microbiota ferment dietary fibres, producing short chain fatty acids. Recent evidence suggests that the short chain fatty acid propionate may play an important role in appetite regulation. We hypothesised that colonic delivery of propionate would increase peptide YY (PYY) and gl...

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Veröffentlicht in:	Gut 2015-11, Vol.64 (11), p.1744-1754
Hauptverfasser:	Chambers, Edward S, Viardot, Alexander, Psichas, Arianna, Morrison, Douglas J, Murphy, Kevin G, Zac-Varghese, Sagen E K, MacDougall, Kenneth, Preston, Tom, Tedford, Catriona, Finlayson, Graham S, Blundell, John E, Bell, Jimmy D, Thomas, E Louise, Mt-Isa, Shahrul, Ashby, Deborah, Gibson, Glen R, Kolida, Sofia, Dhillo, Waljit S, Bloom, Stephen R, Morley, Wayne, Clegg, Stuart, Frost, Gary
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiposity - drug effects Appetite Regulation - drug effects Biomedical research Body Weight Maintenance - drug effects Cells, Cultured Colon - cytology Colon - metabolism Cross-Over Studies Diet Double-Blind Method Fatty acids Female Fermentation Funding Glucagon-Like Peptide 1 - metabolism Gut Microbiota Hormones Humans Male Middle Aged Obesity Overweight - drug therapy Peptide YY - metabolism Peptides Propionates - administration & dosage Propionates - pharmacology Public health Transplants & implants Weight control
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